Protein Alignment Abcd3 and Abcd1

DIOPT Version :10

• Sequence 1: NP_608354.1
• Gene: Abcd3 / 32992
• FlyBaseID: FBgn0031069
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_031461.1
• Gene: Abcd1 / 11666
• MGIID: 1349215
• Length: 736
• Species: Mus musculus
• Alignment Length: 643
• Identity: 247/643 - (38%)
• Similarity: 375/643 - (58%)
• Gaps: 50/643 - (7%)

  Fly    52 EKKDKKAGKAHVNSVFFKQLRQLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMIQNATVVES 116
            |.....|.||.:|.||.::|..||.:|.|.....|||||.|.:|||:.|:...:::.:....:..
Mouse    56 EASGATATKAGMNRVFLQRLLALLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLAR 120

  Fly   117 TIIHMNRTKFKTALLKY-LTALPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYLNGYTYYKMS 180
            .|:..:...|...||:: |.|||| :.:.:.:::..|:|.|.||:.|..|.|..|.:..|||::|
Mouse   121 CIVRKDPRAFSWQLLQWLLIALPA-TFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVS 184

  Fly   181 NLDNRIANADQLLTTDIDKFCESATDLYSNISKPVLDIFIYVYRL-----TVNLGGKTPSILMLY 240
            |:|.|:.|.||.||.|:..|..|...||||::||:||:.:..|.|     :...|...||.:...
Mouse   185 NMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGL 249

  Fly   241 LLFAGVFLTRLRRPT-GRLTVEEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLR 304
            ::|....:.|...|. |.|..||.:.:||.||::||::.||||:|||.|:..|...|..||..|.
Mouse   250 VVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLA 314

  Fly   305 SHLRKFLEFRVSMGIIDNIIGKYFASIVGFYAVSIPF-----FSENH---------PLLSGENSG 355
            |.:...|..|:...:::..:.||..|..|...|::|.     ::|:.         .:...|...
Mouse   315 SQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVS 379

  Fly   356 QRLQAYYTYGRMLVKLAEAIGRLVLAGREMSRLAGFTARMTELIKVLSDLNKGTYERTMVNGNNL 420
            :|.:|:.....:|...|:|..|::.:.:|::.|||:|||:.|:.:|..|:....::||    .:|
Mouse   380 ERTEAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVKHCRFKRT----GDL 440

  Fly   421 AQNAVG------SASSNFGPNK----------GIMCFEDNIIRFEKVPLVTPNGDVLLQELSFEV 469
            .:...|      |.....||.|          ||:|        |.:|::||.|:|::..|:..|
Mouse   441 EEAQAGPGVMVQSGVHVEGPLKIQGQVVDVEQGIIC--------ENIPIITPTGEVVVASLNIRV 497

  Fly   470 KSGTNVLVCGPNGCGKSSLFRILGELWPTWGGKVTKPSRGKLFYVPQRPYMTLGTLRDQIIYPHT 534
            :.|.::|:.|||||||||||||||.||||:.|.:.||...::||:||||||::|:||||:|||.:
Mouse   498 EEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDS 562

  Fly   535 RDDMRRLGHSDEDLMHYLDIVQLTYLEQRENGLDSIEDWIDVLSGGEKQRIAMARLFYHKPQFAI 599
            .:||||.|.|::.|...|.||.|.::.|||.|.:::.||.|||||||||||.|||:|||:|::|:
Mouse   563 AEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYAL 627

  Fly   600 LDECTSAVSVDVEGKMYSYCREVGITLFTVSHRKSLWAHHDYYLQFDGRGSYEFATID 657
            |||||||||:|||||::...::.||.|.:::||.|||.:|.:.|||||.|.::|..:|
Mouse   628 LDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLD 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abcd3	NP_608354.1	3a01203	3..653	CDD:273360	245/637 (38%)
Abcd1	NP_031461.1	3a01203	1..681	CDD:273360	245/637 (38%)
		Interaction with PEX19. /evidence=ECO:0000250|UniProtKB:P33897	67..186		40/119 (34%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000250|UniProtKB:P33897	67..84		7/16 (44%)
		Required for homodimerization. /evidence=ECO:0000250|UniProtKB:P33897	658..736		14/28 (50%)