DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ubqn and ubqln4

DIOPT Version :9

Sequence 1:	NP_001285457.1	Gene:	Ubqn / 32977	FlyBaseID:	FBgn0031057	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_998521.2	Gene:	ubqln4 / 334337	ZFINID:	ZDB-GENE-030131-6269	Length:	599	Species:	Danio rerio

Alignment Length:	586	Identity:	282/586 - (48%)
Similarity:	383/586 - (65%)	Gaps:	72/586 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 INVVVKTPKDKKTVEVDEDSGIKDFKILVAQKFEAEPEQLVLIFAGKIMKDTDTLQMHNIKDNLT 73
            |.|.|||||||:.:.:.||:.:..||..::::|:|:.:||||||||||:||.|||..|.|||.||
Zfish    26 IKVTVKTPKDKEEIAIAEDASVAQFKEEISKRFKAKQDQLVLIFAGKILKDGDTLGQHGIKDGLT 90

  Fly    74 VHLVIKAPTRNNEQPARQ---------------------PADVRQTPFG-------------LNQ 104
            ||||||...:.:...:.|                     ||....||.|             |..
Zfish    91 VHLVIKTAQKTSGAGSSQTSASSGPGPSQGSPSGTDTPSPAGNLGTPQGSGPSPTPSQPANILAG 155

  Fly   105 FGGLAGMEALGAGSNTFMDLQARMQNELLNNGDMLRSLMDNPMVQQMMNNPDTMRQLITSNPQMH 169
            ||.|:|:..||.||..||:||.:||.:|::|.:||..:|:||:||.||:|||.|||:|.:||||.
Zfish   156 FGDLSGLSNLGMGSANFMELQQQMQRQLMSNPEMLSQIMENPLVQSMMSNPDLMRQMIMANPQMQ 220

  Fly   170 DLMQRNPEISHMLNNPDLLRQTMELARNPSMLQELMRSHDRAMSNLESVPGGYSALQRIYRDIQE 234
            .||:||||||||||||:|:||||||||||:|:||:||:.|||:|||||:||||:||:|:|.||||
Zfish   221 QLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALSNLESIPGGYNALRRMYTDIQE 285

  Fly   235 PMMNAATESFGRNPFAGLVDGGGSGAGNNPQQGTENRNPLPNPWGGANSGTNGTVGGSGAGNP-- 297
            ||.:||.|.||.|||:.| .|.|...|..|.: ||||.|||||||    ..:||...:.:|.|
Zfish   286 PMFSAAREQFGNNPFSAL-GGNGENPGTQPSR-TENREPLPNPWG----PPDGTASTTSSGTPTT 344

  Fly   298 ----TGDLPP--------------NNVLNTPAMRSLLQQMADNPAMMQNLLNAPYTRSMMESMSQ 344
                |....|              |.:.|:|.|:||:||:::||.:|||:::|||.|:||:|::|
Zfish   345 TSSTTSSTTPSVSNPLGISSSNLGNGMFNSPGMQSLMQQISENPQLMQNMISAPYMRTMMQSLAQ 409

  Fly   345 DPDMAARLLSSSPLMSNNPALQEQVRQMMPQFMAQMQNPEVMNMLTNPDAMNAILQIQQGMEQLR 409
            :||:|:::|.::||.:.||.||||:||.:|.|:.||||||.::::|||.||.|::|||:|::.|:
Zfish   410 NPDVASQVLMNNPLFAGNPQLQEQMRQQLPVFLQQMQNPEALSVMTNPRAMRALMQIQEGLQTLQ 474

  Fly   410 SAAPGLVGTLGIPPPPPGAGTGTNPASGDGSGGNSGASTNNVSPSSGLNAGTG-TPNLAPGGGPN 473
            :.||||:..||     ||...|..|....|:...:|.:   |:|.:...:|.| ||....|..|.
Zfish   475 TEAPGLMPGLG-----PGGMPGGIPVGMPGAPLPTGVT---VTPENPPPSGQGSTPTPTAGASPA 531

  Fly   474 AQLFNDFMMRMLNGMSNNADNTQPPEVRYQSQLEQLNAMGFVNRDANLQALIATFGDINAAVERL 538
            .|   ..|.:||...:..:.:||.||||:|.|||||:||||:||:|||||||||.||||||:|||
Zfish   532 QQ---QLMQQMLQMFAGGSASTQTPEVRFQQQLEQLSAMGFINREANLQALIATGGDINAAIERL 593

  Fly   539 L 539
            |
Zfish   594 L 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubqn	NP_001285457.1	UBQ	9..79	CDD:214563	40/69 (58%)
		hPLIC_N	9..79	CDD:176403	40/69 (58%)
		STI1	322..368	CDD:128966	23/45 (51%)
		UBA_PLICs	501..537	CDD:270582	28/35 (80%)
ubqln4	NP_998521.2	UBQ	26..96	CDD:214563	40/69 (58%)
		hPLIC_N	26..96	CDD:176403	40/69 (58%)
		STI1	186..223	CDD:128966	21/36 (58%)
		UBA_PLICs	556..595	CDD:270582	32/39 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I756
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1240
OMA	1	1.010	-	-		QHG54270
OrthoDB	1	1.010	-	-		D1553668at2759
OrthoFinder	1	1.000	-	-		FOG0001496
OrthoInspector	1	1.000	-	-		oto41498
orthoMCL	1	0.900	-	-		OOG6_100933
Panther	1	1.100	-	-	LDO	PTHR10677
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X761
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840