Protein Alignment car and Vps33a

DIOPT Version :10

• Sequence 1: NP_001259707.1
• Gene: car / 32947
• FlyBaseID: FBgn0000257
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_084205.3
• Gene: Vps33a / 77573
• MGIID: 1924823
• Length: 598
• Species: Mus musculus
• Alignment Length: 625
• Identity: 276/625 - (44%)
• Similarity: 388/625 - (62%)
• Gaps: 41/625 - (6%)

  Fly     1 MFPHLKGHGQRVNLQLLQEAACRELLQQLDRIEGSKVIVLDETMIGPLDLVTR---------PKL 56
            |..|| .:| ||||.:|:||..|||.:.||:..|||.||.||.:.||..|:.:         .|:
Mouse     1 MAAHL-SYG-RVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKM 63

  Fly    57 FADRGIRLLALKPELHLPREVANVVYVMRPRVALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCL 121
            |..:|.||.|        .:|.|:::::|||:.||:.:|.:|.:..|....|.:||||.||||.|
Mouse    64 FTLKGSRLPA--------ADVKNIIFLVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLL 120

  Fly   122 CVSQLEVSGVLGSFGNIEELAWNYLPLDVDLVSMEMPNAFRDVSVDGDTSSLYQAAVGLVQLQRL 186
            |..:|:..||||||.:.||.:.:.:|.|.||:|||...||::..::||.:|||.||.||:.||.|
Mouse   121 CEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMESEGAFKECYLEGDQTSLYHAAKGLMTLQAL 185

  Fly   187 YGRIPKIYGKGEFAHRVWEHAKQLGRDERTLYNGDKGVVDQLILLDRSIDLLSPLATQLTYEGLI 251
            ||.||:|:||||.|.:|.....::.|:.....|....|.|.|:||||::|||:|||:||||||||
Mouse   186 YGTIPQIFGKGECARQVANMMVRMKREFTGSQNSVFPVFDNLLLLDRNVDLLTPLASQLTYEGLI 250

  Fly   252 DEFYGIRQNKLTLPAENFPSDGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQLYAELRNKH 316
            ||.|||:.:.:.||.|.|   .....|||||     .:.|  .||.|.:.|:|.|:||||:|:|:
Mouse   251 DEIYGIQNSYVKLPPEKF---APKKQGGGSG-----GKDL--PTEAKKLQLNSAEELYAEIRDKN 305

  Fly   317 FNEVTKLLARKAREIHVQMHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNA 381
            ||.|..:|::||:.|..........|:|.|||.||.. ||.:.|.:.:.:.||:||.|:.:...:
Mouse   306 FNAVGSVLSKKAKIISAAFEERHNAKTVGEIKQFVSQ-LPHMQAARGSLANHTSIAELIKDVTTS 369

  Fly   382 VRFADDLAAEQEFMVCADIDKPSAYIEDLIACRVELNRVLRLICMQCHAASGFKEKLLNHYKREL 446
            ..|.|.|..|||||...|.||.::||||.||.:..|.:||||:|:|....||.|:|:|::|:||:
Mouse   370 EDFFDKLTVEQEFMSGIDTDKVNSYIEDCIAQKHPLIKVLRLVCLQSVCNSGLKQKVLDYYRREI 434

  Fly   447 VHVYGLEVLLTISNLEKSGLLHLQTESR-AYSVLRKTLHLTVDDNVEIEPKDISYVHSFYAPLTA 510
            :..||.|.:||::||||:|||..||..| .|..:||||.|.:||..|..|.|||||:|.||||:.
Mouse   435 LQTYGYEHILTLNNLEKAGLLKAQTGGRNNYPTIRKTLRLWMDDVNEQNPTDISYVYSGYAPLSV 499

  Fly   511 RIVEHSLKPLGWQTLKSQINNLPGPTFEDFQAQLVGIGGRHTVTTVSEGSLLNVPRVVLVCFVGG 575
            |:.:...:| ||::::..:..||||.||:.|....|:..:.     ..|.    .||.||.|:||
Mouse   500 RLAQLLSRP-GWRSIEEVLRILPGPHFEERQPLPTGLQKKR-----QPGE----NRVTLVFFLGG 554

  Fly   576 CTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSFLDSLM 615
            .|||||||||||:..||...|::|||||::|.:|::::||
Mouse   555 VTFAEIAALRFLSQLEDGGTEYVIATTKLMNGNSWIEALM 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
car	NP_001259707.1	Sec1	36..613	CDD:460020	256/586 (44%)
Vps33a	NP_084205.3	Sec1	34..591	CDD:460020	256/585 (44%)