Protein Alignment car and VPS33B

DIOPT Version :10

• Sequence 1: NP_001259707.1
• Gene: car / 32947
• FlyBaseID: FBgn0000257
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_061138.3
• Gene: VPS33B / 26276
• HGNCID: 12712
• Length: 617
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 181/654 - (27%)
• Similarity: 304/654 - (46%)
• Gaps: 85/654 - (12%)

  Fly     2 FPHLKGHGQRVNLQLLQEAACRELLQQLDRIEGSKVIVLDETMIGPLDLVTRPKLFADRGIRLL- 65
            |||.....:..:..:|:..|..:|:..|:::.|.|.:.::..::.|||.:....:.....:..|
Human     3 FPHRPDAPELPDFSMLKRLARDQLIYLLEQLPGKKDLFIEADLMSPLDRIANVSILKQHEVDKLY 67

  Fly    66 --ALKPELHLPREVANVVYVMRPRVALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCLCVSQLEV 128
              ..||.|....::.   :::|||:..|..:|:.|.|...|...|:|.::|:|::...|...||.
Human    68 KVENKPALSSNEQLC---FLVRPRIKNMRYIASLVNADKLAGRTRKYKVIFSPQKFYACEMVLEE 129

  Fly   129 SGVLGSFGNIEELAWNYLPLDVDLVSMEMPNAFRDVSVDGDTSSLYQAAVGLVQLQRLYGRIPKI 193
            .|:.|.. :.:|.|::.|||||||:|||:|..|||..::||...:...|..|..|..|||..|..
Human   130 EGIYGDV-SCDEWAFSLLPLDVDLLSMELPEFFRDYFLEGDQRWINTVAQALHLLSTLYGPFPNC 193

  Fly   194 YGKGEFAHRVWEHAKQLGRDERTLYNGDKGVVDQLILLDRSIDLLSPLATQLTYEGLIDEFYGIR 258
            ||.|..|...:|..:.|..:|.....|.:..:..:.||||.:|.::.|.:|:.||||:|:.:.|:
Human   194 YGIGRCAKMAYELWRNLEEEEDGETKGRRPEIGHIFLLDRDVDFVTALCSQVVYEGLVDDTFRIK 258

  Fly   259 QNKLTLPAENFPSDGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQLYAELRNKHFNEVTKL 323
                             .|....||.|..|...|      .:||::.::::.|:||:||:.|...
Human   259 -----------------CGSVDFGPEVTSSDKSL------KVLLNAEDKVFNEIRNEHFSNVFGF 300

  Fly   324 LARKAREIHVQMHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNAVRFADDL 388
            |::|||.:..| :...:...::::|:||...|..|..:.:..|.|......:.::.....|.:.:
Human   301 LSQKARNLQAQ-YDRRRGMDIKQMKNFVSQELKGLKQEHRLLSLHIGACESIMKKKTKQDFQELI 364

  Fly   389 AAEQEFMVCADIDKPSAYIEDLIACRVELNRVLRLICMQCHAASGFKEKLLNHYKRELVHVYGLE 453
            ..|...:...:|.:.::|||:.|..:|.....|||:|:.....:|...|.....|.:.:..||.|
Human   365 KTEHALLEGFNIRESTSYIEEHIDRQVSPIESLRLMCLLSITENGLIPKDYRSLKTQYLQSYGPE 429

  Fly   454 VLLTISNLEKSGLL-----------------HLQTESRA---------------YSVLRKTLHL- 485
            .|||.|||.::|||                 .|.|:..|               :..:.|.|:|
Human   430 HLLTFSNLRRAGLLTEQAPGDTLTAVESKVSKLVTDKAAGKITDAFSSLAKRSNFRAISKKLNLI 494

  Fly   486 -TVDDNVEIE-PKDISYVH-SFYAPLTARIVEHSLKPLGWQTLKSQIN--NLPGPTFEDFQAQLV 545
             .||...::: |:|::||. ..|.||:.||:|..|:...||.|...:.  |.....|.|...:
Human   495 PRVDGEYDLKVPRDMAYVFGGAYVPLSCRIIEQVLERRSWQGLDEVVRLLNCSDFAFTDMTKE-- 557

  Fly   546 GIGGRHTVTTVSEGSLLNVPRVVLVCFVGGCTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSF 610
                    ...|..||    |::||.|:|||||:||:|||||.  .:....|:..||.|.|....
Human   558 --------DKASSESL----RLILVVFLGGCTFSEISALRFLG--REKGYRFIFLTTAVTNSARL 608

  Fly   611 LDSL 614
            ::::
Human   609 MEAM 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
car	NP_001259707.1	Sec1	36..613	CDD:460020	173/617 (28%)
VPS33B	NP_061138.3	Sec1	37..610	CDD:460020	173/616 (28%)