Protein Alignment car and vps-33.2

DIOPT Version :10

• Sequence 1: NP_001259707.1
• Gene: car / 32947
• FlyBaseID: FBgn0000257
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_495342.2
• Gene: vps-33.2 / 174095
• WormBaseID: WBGene00016960
• Length: 617
• Species: Caenorhabditis elegans
• Alignment Length: 640
• Identity: 161/640 - (25%)
• Similarity: 271/640 - (42%)
• Gaps: 89/640 - (13%)

  Fly    14 LQLLQEAACRELLQQLDRIEGSKVIVLDETMIGPLDLVTRPKLFADRGIRLLALKPELHLPREVA 78
            |.||:....||.:..|:.:.|:|.:.:|:.::.|||::.........|::.: :..:|....:|.
 Worm    14 LHLLRMVMQREFIHYLETLPGTKELFIDKCLLRPLDMIATSSDMKRHGVKRI-MHFDLQKSPQVW 77

  Fly    79 NV-----VYVMRPRVALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCLCVSQLEVSGVLGSFGNI 138
            |:     |:.:||.|....::..:|:   .::..|...:::..|:...|....|.|||:   |:|
 Worm    78 NIEIDQRVFFLRPNVENARKIVEYVE---ESSENRSICVIWCNRQLEECDLAFESSGVI---GHI 136

  Fly   139 EELAWN--YLPLDVDLVSMEMPNAFRDVSVDGDTSSLYQAAVGLVQLQRLYGRIPKIYGKGEFAH 201
            .:|:.|  .|||:.||.|::        .|:.....|:..|...|.||.|||.||.:||.|..:.
 Worm   137 TQLSLNMCLLPLESDLFSLQ--------HVESAQPDLFSVANMFVALQNLYGVIPTVYGLGSESK 193

  Fly   202 RVWEHAKQLGRDERTLYNGDKGVVDQLILLDRSIDLLSPLATQLTYEGLIDEFYGIRQNKLTLPA 266
            .:|.....|..........|: .:..|.|.||.:|.:..|.|..:||||:.||:.|...||..|.
 Worm   194 NLWNLVHALCSSNELRARPDQ-PISHLFLFDRQLDPVPVLLTGASYEGLLHEFFTIDCGKLAFPV 257

  Fly   267 ENFPSDGALPGGGGSGP--------RVEESQSLLGDTEKKTILLHSGEQLYAELRNKHFNEVTKL 323
            :       |.....:||        ..||.:.........|:.|.:.|.::|.:||||.....:.
 Worm   258 D-------LRKQVQTGPLDFDWIEINPEEDKEAHQQNRGDTVKLDNCEDIFASIRNKHVTAALEF 315

  Fly   324 LARKAREIHVQMHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNAVRFADDL 388
            |..||:.|...:..:|....|.:.::|||..|..|....|....|.....::..:|....:....
 Worm   316 LHSKAKSIQKSIEKSSMIDDVADYRNFVEKDLRALKKDHKHCELHINACEMMMNKVKMEDYRTMF 380

  Fly   389 AAEQEFMVCADIDKPSAYIEDLIACRVELNR----VLRLICMQCHAASGFKEKLLNHYKRELVHV 449
            ..|.| |:...:.....:  |.:..||.:..    ||.::.:......|..:...|.:....:..
 Worm   381 KLEHE-MLLGTVTHEEYF--DFVFERVPMRSCRDVVLSMMSLASLKLDGVPDDTYNEFVEMYLQK 442

  Fly   450 YGLEVLLTISNLEKSGLLH----------LQTESRAYSVLRKTLHLTVDDNVEIE---PKDISYV 501
            ||.|.:..:.||..|.:::          :...:|.:..|.:...: |..|..::   |.|:|||
 Worm   443 YGYEHMFELQNLRNSRVIYARRHIAHDRTISERARTWETLARKFRI-VKGNEPMDMSNPSDMSYV 506

  Fly   502 H-SFYAPLTARIVEHSLKPLGWQTLKSQINNLPGPTFEDFQAQLVGIGGRHTVTTVSEGSLL--- 562
            . :..:||..:|||.::.. ||.                 ||:...|.|:..| .|.|.:.:
 Worm   507 FGARISPLLCKIVEDTIDH-GWN-----------------QAEYERIIGKDKV-LVEENTYIAAD 552

  Fly   563 ----NVPRVVLVCFV-GGCTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSFLD 612
                |..|..::.|| ||.|:.|:||||.||.|:  |...||.||.|:.|..:|:
 Worm   553 RRPDNRTRKAIMVFVNGGITYWEVAALRLLAIQK--NFRILICTTHVIKKREYLE 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
car	NP_001259707.1	Sec1	36..613	CDD:460020	154/618 (25%)
vps-33.2	NP_495342.2	Sec1	36..605	CDD:460020	153/616 (25%)