Protein Alignment Vav and Vav3

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_001365916.1
• Gene: Vav3 / 57257
• MGIID: 1888518
• Length: 875
• Species: Mus musculus
• Alignment Length: 1117
• Identity: 280/1117 - (25%)
• Similarity: 435/1117 - (38%)
• Gaps: 387/1117 - (34%)

  Fly    21 WRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQ 85
            |::|..||...||:||:|:.....|::..||.|||||||||.|:.:|.|.|::.:|.|.:|||:|
Mouse     4 WKQCAQWLIHSKVLPPNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRPHSINLKEINLRPQMSQ 68

  Fly    86 FLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNL 150
            |||.|||:.||..|.:.||:|.::|||...|:|:.:|.:|:.|||:||:.       |..:...:
Mouse    69 FLCLKNIRTFLAACCDTFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRT-------PIALATGI 126

  Fly   151 QLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTED 215
            :..|||.|.:||.|||
Mouse   127 RPFPTEESINDEDIYK------------------------------------------------- 142

  Fly   216 IDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPT 280
                   .|.::.|.|...|.||       |.||
Mouse   143 -------GLPDLIDETRVEDEED-------LYDC------------------------------- 162

  Fly   281 PESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMA 345
                                                                             
Mouse   163 ----------------------------------------------------------------- 162

  Fly   346 STEHEYAYIYSEDD-EKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALH 409
                    :|.||: .:|||||                             .|.||
Mouse   163 --------VYGEDEGGEVYEDL-----------------------------MKAEE--------- 181

  Fly   410 RTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELV 474
                :|...|...:.|...:.|:..||..|.:.|.:::..||.||:|.|...|...:|..|.:||
Mouse   182 ----AQQPKSQENDIRSCCLAEIRQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPDLV 242

  Fly   475 DIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQ 539
            .:|...:.::.:|:.......:.|||::::|..:|||::||.:..||..|..:.|..:.:...::
Mouse   243 KVHRSLMQEIHDSIVNKDDQNLYQVFINYKERLVIYGQYCSGVESAISNLDYISKTKEDVKLKLE 307

  Fly   540 KCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHD--DYRSLERAKEAMIDVSQYIN 602
            :|.:..|.||..|||:|.|||||:|||||||.:|||.|   ||  :..:|:.|.:||.|::||:|
Mouse   308 ECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT---HDPMEKANLKLALDAMKDLAQYVN 369

  Fly   603 EVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDK 667
            |||||::.|..|::.:.||      :|.| ..:|.:||...|||:.|...:....:.|:.|:||.
Mouse   370 EVKRDNETLREIKQFQLSI------ENLN-QPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDL 427

  Fly   668 ILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLK 732
            .:|:.|    :.|| .|..::..:|..|::  :::..|...:.::.|...|....|:.....|.|
Mouse   428 AVIVCK----RKGD-NYEMKEIIDLQQYKI--ANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCK 485

  Fly   733 SEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQIS 797
            ::..:.||.:....|:.::.|....|..|..:::||...|:||.|...|:|..:|||.|..|...
Mouse   486 TKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCRVCQMLLRGTFYQGYLCFKCGAK 550

  Fly   798 VHKGCISSTGRC------KQNPVSVP--------------------------------------P 818
            .||.|:.....|      :|.|...|                                      |
Mouse   551 AHKECLGRVDNCGRVNSVEQGPFKPPEKRTNGLRRASRQVDPGLPKMQVIRNYTGTPAPGLHEGP 615

  Fly   819 PV------------------------------------------CDRQLSEFN---WFAGNMDRE 838
            |:                                          |..:..:::   |:||.|:|.
Mouse   616 PLHIQAGDTVELLRGDAHSVFWQGRNLASGEVGFFPSDAVKPSPCVPKPVDYSCQPWYAGPMERL 680

  Fly   839 TAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRH 903
            .|...|.||...|||:|.|     |.....||:|:|. :|..||:||...:.    .:.::..|.
Mouse   681 QAETELINRVNSTYLVRHR-----TKESGEYAISIKY-NNEAKHIKILTRDG----FFHIAENRK 735

  Fly   904 FKTIVELVSYYERNDLGENFAGLNQSLQWPYKEV------------------------------- 937
            ||:::|||.||:.:.|.|.|..|:.:||:||||.
Mouse   736 FKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEQPAGQRGNRTGNSSPPLFCGFSFVTPPDYS 800

  Fly   938 -------------------IATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTV 983
                               ||.|.||:..: ...:|.|.....|.:..| ..:.|||||::...|
Mouse   801 FVPPSSTPFWSVLSPKVLGIAIARYDFCAR-DMRELSLLKGDMVKIYTK-MSANGWWRGEVNGRV 863

  Fly   984 GYFPKEYVQEQK 995
            |:||..||:|.:
Mouse   864 GWFPSTYVEEDE 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	55/113 (49%)
		RhoGEF	428..602	CDD:459876	64/175 (37%)
		PH_Vav	624..753	CDD:269930	29/128 (23%)
		C1_VAV	759..810	CDD:410360	18/56 (32%)
		SH2_Vav_family	824..934	CDD:198193	38/112 (34%)
		SH3	940..993	CDD:473055	18/52 (35%)
Vav3	NP_001365916.1	CH_VAV3	2..118	CDD:409113	55/113 (49%)
		RhoGEF	193..369	CDD:238091	65/178 (37%)
		PH_Vav	383..506	CDD:269930	31/136 (23%)
		C1_VAV3	506..564	CDD:410419	20/57 (35%)
		SH3_VAV3_1	596..657	CDD:212914	2/60 (3%)
		SH2_Vav3	666..768	CDD:198270	40/111 (36%)
		SH3_VAV3_2	819..874	CDD:212911	20/56 (36%)