DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulp1 and SENP7

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	XP_011511340.1	Gene:	SENP7 / 57337	HGNCID:	30402	Length:	1051	Species:	Homo sapiens

Alignment Length:	1100	Identity:	210/1100 - (19%)
Similarity:	354/1100 - (32%)	Gaps:	401/1100 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   689 VNEGQRDRELVSYTGHEHQNFVDEVSTPLPPAEAQPGSTSED--ISDPVSP-----------EHW 740
            :.||:|.:.                |:.|........:..||  :..|:|.           :.|
Human    16 ITEGKRKKS----------------SSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPLQVW 64

  Fly   741 EQLESLDPSTICI-RKTFNLIRDISESLVADPEQP---------EAEAHRKSIFLLRQKLADVC- 794
            |:  ||....|.: .|....||....:..:.||:.         ..:..||....|.:..|::|
Human    65 ER--SLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRNDANLCD 127

  Fly   795 -HKVLTEIIHGRATDEI-----ISILREILEQTKEIPPRPTPKRDLQEDISMGLEILKK-IR--- 849
             :||.::.:...:.|.:     :..||:.|..::.||      |.:..:: :|.|:.:| ||
Human   128 ANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERIP------RVILTNV-LGTELGRKYIRTPP 185

  Fly   850 ---GMLSGWYSSRESETDSTDTGTGFQAQN----------GKGFGAGRQPENSFLSQKRRNQEEN 901
               |.||...:.:..:..|:..|:....||          .:|....:..:::...|...|:|:
Human   186 VTEGSLSDTDNLQSEQLSSSSDGSLESYQNLNPHKSCYLSERGSQRSKTVDDNSAKQTAHNKEK- 249

  Fly   902 PRLIKYRRVDNSFPRLITNETAEDLIPNNSMAKRDQPQSSKRLSIFNPPV-YTQHRVRNDAPHVP 965
                  ||.|:....||::...|||  |:.....|..:...|    |..| |:..:|.
Human   250 ------RRKDDGISLLISDTQPEDL--NSGSRGCDHLEQESR----NKDVKYSDSKVE------- 295

  Fly   966 TPFDDEESSQRLANAGPSSRPMTYSDAVRLGHNGISESRVNGHSSHTVRREPSRLHRSILSHEMN 1030
            ......::.:||.|..|.|:..|..|.               .:..|.::|..    |.:|.|..
Human   296 LTLISRKTKRRLRNNLPDSQYCTSLDK---------------STEQTKKQEDD----STISTEFE 341

  Fly  1031 CKDQEQYNELIRTQTNYVGSRYLKPGTPPTFQRAKAQSATSSSCSLQDNQSNITDSFPSPHGRAN 1095
             |..|.|::              .|..|........:|..:...||...:..::::..|....:.
Human   342 -KPSENYHQ--------------DPKLPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGST 391

  Fly  1096 PELTE---------YAKLINRQENEENRSPAPQQPKRNASNSSASHASTISSSASSSCSTCSTCS 1151
            .|..|         .:.|:.:.|||.|....|.....|..|.|...|..|             ..
Human   392 TETVENSNSIDIVGISSLVEKDENELNTIEKPILRGHNEGNQSLISAEPI-------------VV 443

  Fly  1152 SSDTEPMLVKDSPEVKEANEANEANEANEANETKEN---DAP----------------------- 1190
            |||.|..:...|.|:.:.....:....||...|.|:   :.|
Human   444 SSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESALLELPLITCESVQMSSELCPYNPVMENI 508

  Fly  1191 ---QPTTTRIKKPDFLHRRF---------ANCIFLRNDFAE-NFKARANRRQL--ESMHL--LGI 1238
               .|:.....:.||:....         ..|:.:...:.: .|:...|...|  ::.||  .|:
Human   509 SSIMPSNEMDLQLDFIFTSVYIGKIKGASKGCVTITKKYIKIPFQVSLNEISLLVDTTHLKRFGL 573

  Fly  1239 AEQQANESKDERLAYEKKLREVMF----------------------RSGAPHRPFFEI-GPLEQP 1280
            .     :|||:.  :.|:...::|                      :|.:....|.|: .|:.|.
Human   574 W-----KSKDDN--HSKRSHAILFFWVSSDYLQEIQTQLEHSVLSQQSKSSEFIFLELHNPVSQR 631

  Fly  1281 EEKK------ETKLI----------------PL-----TKEDH----------------ARFQEM 1302
            ||.|      |..:|                ||     :||..                |..:||
Human   632 EELKLKDIMTEISIISGELELSYPLSWVQAFPLFQNLSSKESSFIHYYCVSTCSFPAGVAVAEEM 696

  Fly  1303 T----------------------------TIEVTTN-----------------LIF-----KYNL 1317
            .                            ::.:|:|                 :::     |..|
Human   697 KLKSVSQPSNTDAAKPTYTFLQKQSSGCYSLSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGL 761

  Fly  1318 QITTDDIFTFVDGEWLNDAIINFYMSMLTERSEKRAGEL-PATYAMNTFFM-------------- 1367
            .:|.:|:....:||:|||.||:||:..|.  .||.:.|| ..::..::||.
Human   762 GVTNEDLECLEEGEFLNDVIIDFYLKYLI--LEKASDELVERSHIFSSFFYKCLTRKENNLTEDN 824

  Fly  1368 PRL--LQAGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAII--------------------- 1409
            |.|  .|..:..||.|||.:::|:||.|.|||: .:.||.:|:|
Human   825 PNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVN-ESSHWYLAVICFPWLEEAVYEDFPQTVSQQS 888

  Fly  1410 -----HLRNKT------------------------------------IFYYDSMGRPN-QPALDA 1432
                 ...|||                                    |...||:...: |..:..
Human   889 QAQQSQNDNKTIDNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQN 953

  Fly  1433 LVKYLHEESLDKRK--QPFDMTGFVVENAQNIPRQGNSSDCGVFSCMFAEYITRDVPITF 1490
            |.:||..|...|.|  :.|..|. :|:....:|:|.|||||||:...:.|...:|..:.|
Human   954 LREYLEVEWEVKLKTHRQFSKTN-MVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNF 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	61/241 (25%)
SENP7	XP_011511340.1	Peptidase_C48	775..1012	CDD:304959	61/240 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810