DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulp1 and Senp18

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	NP_001002834.1	Gene:	Senp18 / 408222	RGDID:	1303230	Length:	475	Species:	Rattus norvegicus

Alignment Length:	646	Identity:	167/646 - (25%)
Similarity:	244/646 - (37%)	Gaps:	194/646 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   881 GAGRQPENSFLSQKRRNQEENPRLIKYRRVDNSFPRLITNETAEDLIPNNSMAKRDQPQSSKRLS 945
            |.|.:||.|...:||::.::|.                |...:|.|.|..|...:|..|     .
  Rat     8 GVGMKPEASEQRRKRKHLDQNG----------------TETESEALGPEPSRNCQDGAQ-----M 51

  Fly   946 IFNPPVYTQHRVRNDAPHVPTPFDDEESSQRLANAGPSSRPMTYSDAVRLGHNGISESRVNGHSS 1010
            :|..|                                                  .::|...|..
  Rat    52 VFQKP--------------------------------------------------GKARKKTHQE 66

  Fly  1011 HTVRREPSRLHRSILSHEMNCKDQEQYNELIRTQTNYVGSRYLKP--GTPPTFQRAKAQSATSSS 1073
            |..::         |:.|...|.|.|     :||..  ||..:||  |.|.  |....:|.....
  Rat    67 HQDQK---------LNKEQPGKGQGQ-----KTQDE--GSGNIKPLEGLPD--QAVVEKSTEGGK 113

  Fly  1074 CSLQDNQSNITDSFPSPHGRANPELTEYAKLINRQENEENRSPAPQQPKRNASNSSASHASTISS 1138
            |                  |..|    |:.|     .|:.:||..::..|:..:....|.
  Rat   114 C------------------RKRP----YSVL-----QEKPQSPQNEKHARSLEHLQGGHP----- 146

  Fly  1139 SASSSCSTCSTCSSSDTEPMLVKDSPEVKEANEANEANEAN------EANETKENDAPQPTTTRI 1197
                                 |:..|.......::.:|...      ...||...|. ||:|..:
  Rat   147 ---------------------VRSDPHRPHPTFSDTSNNKGGMPGHPHGRETAHGDR-QPSTEVL 189

  Fly  1198 KKPDFLHRRFANCIFLRNDFAENFKARANRRQLESMH-LLGIAEQQANESKDERLAYEKKLREVM 1261
            ..     :|...|       ||....|.|  .||  | |.|.|.....:|...||..:|......
  Rat   190 ST-----KREKRC-------AEEKCVRGN--SLE--HGLPGTANANILDSGGGRLLPDKVAVVAG 238

  Fly  1262 FRSGAPHRPFFEIGPLEQPEEKKETKLIPLTKEDHARFQEMTTIEVTTNLIFKYNLQITTDDIFT 1326
            .::..|.:        |..:||:.||  .:.||...........|:   |...:.|:||..|:.|
  Rat   239 EKNALPEQ--------ENNQEKEFTK--EMEKEVEKALGPGAQEEI---LSTGFKLKITRGDMQT 290

  Fly  1327 FVDGEWLNDAIINFYMSMLTERSEKRAGELPATYAMNTFFMPRLLQAGYAGVRRWTRKVDLFSKD 1391
            ..:|:||||.:|||||::|.:|:|...  .||.:|.:|||..:|...||..|:||||.::||.|:
  Rat   291 LKNGQWLNDEVINFYMNLLVQRNENPG--YPALHAFSTFFYAKLKHGGYNSVKRWTRGINLFEKE 353

  Fly  1392 IIPVPVHCGNVHWCMAIIHLRNKTIFYYDSMGRPNQPALDALVKYLHEESLDKRKQPFDMTGFVV 1456
            :|.||:| ..|||.:.:|.||.::|.|.||||:..:...:.:..||..||..:|....|    .|
  Rat   354 LILVPIH-QRVHWSLVVIDLRKRSIVYLDSMGQTGKNICETIFHYLQNESKTRRNMELD----PV 413

  Fly  1457 E------NAQNIPRQGNSSDCGVFSCMFAEYITRDVPITFSQAEMLYFRTKMALEIADGKL 1511
            |      .:|.||:|.|.||||:|:|.:|:||:||.|:||||..|..||.:|..||....|
  Rat   414 EWKQYSLTSQEIPQQLNGSDCGMFTCKYADYISRDQPVTFSQQHMPLFRKRMVWEILHSHL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	78/180 (43%)
Senp18	NP_001002834.1	Peptidase_C48	<244..470	CDD:304959	95/245 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339698
Domainoid	1	1.000	189	1.000	Domainoid score	I3195
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	1	1.000	-	-		FOG0000698
OrthoInspector	1	1.000	-	-		mtm8978
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12606
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.810