DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ulp1 and Senp1

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	XP_006520943.1	Gene:	Senp1 / 223870	MGIID:	2445054	Length:	698	Species:	Mus musculus

Alignment Length:	762	Identity:	212/762 - (27%)
Similarity:	316/762 - (41%)	Gaps:	202/762 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   859 RESETDSTDTGTGFQA------QNGKGFGAGRQPENSFLSQKRRNQEENPRLIKYRRVDNSFPRL 917
            :..|.|.|..|....|      .:|..|...|.|::.|..::....::.....:...:|.||
Mouse    29 KRPEMDDTADGVKMDAGEVTLVNHGSTFRTHRPPQSGFPEEQLLLSDQQSLPFRQGTLDGSF--- 90

  Fly   918 ITNETAEDLIPNNSMAKR-----DQPQSSKRLSIFNPPVYTQH---RVRNDAPHVPTPFDDEESS 974
             |..|       .|.|.|     |.|.|...|...:...:.|.   :.||..|
Mouse    91 -TCST-------RSPAYRPDYHSDNPSSDSFLGSGDVRTFGQSANGQWRNSTP------------ 135

  Fly   975 QRLANAGPSSRPMTYSD---AVRLGHNGISESRVNGHSSH-----------TVRREPS-----RL 1020
               |:.....:|.....   ..|...:|:|.:.| |.|:|           .::..||     ..
Mouse   136 ---ASGSAPQKPRNSRSLCLETRKTSSGLSNTFV-GKSNHHCHMSAYEKSFPIKPAPSPSWSGSC 196

  Fly  1021 HRSILS-------HEMNCKD--QEQYNELIRTQTNYVGSRYLKPGTPPTFQRAKAQSATSSSCSL 1076
            .||:||       |....::  ||:..|:.|.....|..:......|.|....:.     |.| |
Mouse   197 RRSLLSPKKTQRRHFSTAEETVQEEEKEIYRQLLQMVTGKQFCVAKPTTHFPLRL-----SRC-L 255

  Fly  1077 QDNQSNITDSFPSPHGRANPELTEYAKLINRQENEENRSPAPQQPKRNASNSSASH--ASTISSS 1139
            ..|::::.||.                                  .|| .||.|||  .|..|||
Mouse   256 SSNKNSLKDSL----------------------------------LRN-GNSCASHVIGSDTSSS 285

  Fly  1140 ASSSCSTCS-----------------TCSSSDTEPMLVKDSPEVKEANEANEANEANEANET--- 1184
            .|:|..|..                 ...|.|::|.....:|.  :.|....:|..:|.:::
Mouse   286 GSASILTAQEQLSHSAHSLSSGTPDVAFGSKDSDPHHHLAAPH--QPNSLPASNTQSEGSDSVIL 348

  Fly  1185 ---KENDAPQPTTTRIKKPDFLHRR-------FANCIFLRNDFAENFKARANRRQLESMH----- 1234
               ||:..|   .:|...|  |.||       ::..:.|.:.....|:|....::|.|::
Mouse   349 LKVKESQTP---ASRYLSP--LKRRSCPYIIPYSAVMDLLSSSPTFFQAELWIKELTSVYDSRAR 408

  Fly  1235 --LLGIAEQQ--ANESKDERLAYEKKLREVMFRSGAPHRPFFEIGPLEQPEEKKETKLIPLT--- 1292
              |..|.||:  |.:.:::||   ::....:..|...|        |..|.||:    ||:|
Mouse   409 ERLRRIEEQKALALQLQNQRL---QEQEHAVLDSVELH--------LRVPLEKE----IPVTAAQ 458

  Fly  1293 ---KEDHA------RFQEMT-TIEVTTNLIFK-----------YNLQITTDDIFTFVDGEWLNDA 1336
               |:.|.      .|.|:| .:|.....:|:           :.|.||..||.|.....||||.
Mouse   459 ETRKKSHQLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDE 523

  Fly  1337 IINFYMSMLTERSEKRAGELPATYAMNTFFMPRLLQAGYAGVRRWTRKVDLFSKDIIPVPVHCGN 1401
            ||||||:||.|||:::.  .|:.:|.||||..:|..|||..|:|||:|||:||.||:.||:|.|
Mouse   524 IINFYMNMLMERSKEKG--FPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLG- 585

  Fly  1402 VHWCMAIIHLRNKTIFYYDSMGRPNQPALDALVKYLHEESLDKRKQPFDMTGFVV--ENAQNIPR 1464
            ||||:|::..|.|:|.||||||..|..|...|::||.:||:||:::.||..|:.:  :.:|.||:
Mouse   586 VHWCLAVVDFRRKSITYYDSMGGINNEACRILLQYLKQESVDKKRKEFDTNGWQLFSKKSQEIPQ 650

  Fly  1465 QGNSSDCGVFSCMFAEYITRDVPITFSQAEMLYFRTKMALEIADGKL 1511
            |.|.||||:|:|.:|:.||:|.||.|:|..|.|||.:|..||...||
Mouse   651 QMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKL 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	90/176 (51%)
Senp1	XP_006520943.1	mukB	<407..>501	CDD:235316	23/108 (21%)
Senp1	XP_006520943.1	Peptidase_C48	<474..696	CDD:390099	103/224 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3284
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1480705at2759
OrthoFinder	1	1.000	-	-		FOG0000698
OrthoInspector	1	1.000	-	-		mtm8739
orthoMCL	1	0.900	-	-		OOG6_101235
Panther	1	1.100	-	-	LDO	PTHR12606
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.780