DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ulp1 and Senp6

DIOPT Version :9

Sequence 1:	NP_573362.1	Gene:	Ulp1 / 32910	FlyBaseID:	FBgn0027603	Length:	1513	Species:	Drosophila melanogaster
Sequence 2:	NP_001298039.1	Gene:	Senp6 / 215351	MGIID:	1922075	Length:	1139	Species:	Mus musculus

Alignment Length:	960	Identity:	183/960 - (19%)
Similarity:	334/960 - (34%)	Gaps:	306/960 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   576 DQEEDQHYLNFEGNQQFQLQKQDQ----------LSVPQIQKQTHQFESKVKK-RKLQPFSEYQQ 629
            |:.|.:....|:.|..|..:::.:          |||       ...:|::.| :||...||...
Mouse    19 DRSESKRDGGFKNNWSFDHEEESEGDADKDGANLLSV-------EDEDSEISKGKKLNRRSEIVA 76

  Fly   630 KGQKDHIQERQYIQQEFT---------------IHSNQAYSKVQYIQTIQTA-----TPYVPQLE 674
            ....|.|. :.|:::..|               :.:|:..|:    .|..||     ..:..:..
Mouse    77 TSSGDFIL-KTYVRRSKTDGFKTLKGNPIGLNMLSNNKKLSE----STAGTALCSGTVVHGRRFH 136

  Fly   675 ISQENSFEVQPAYEVNEGQRDRELVSYTGHEHQNFVDEVSTPLPPAEAQPGSTSEDISDPVSPEH 739
            .:...:..::.|.:.|:.:::|:  .|..:.|:            ||          :.||...|
Mouse   137 HAHSQTPGIRTAAQSNQDRKERK--EYPPYVHK------------AE----------NSPVMLSH 177

  Fly   740 WEQLESLDPSTICIRKTFNLIRDISESLVADPEQPEAEAHRKSIFLLRQK----------LADVC 794
            .:..:.:      ::||     :.|||.|      |:|..||    ::||          |:...
Mouse   178 GQGGDHI------MKKT-----EESESYV------ESEIKRK----VQQKRHCSTYQLSPLSPAS 221

  Fly   795 HKVLTEIIHGRATDEIISILREILEQTKEIPPRPTPKRDLQEDISMGLEILKKIRGMLSGWYSSR 859
            .|.||.:              |:.||.:..|.....|.:..:..|.|:.....::      .:.|
Mouse   222 KKCLTHL--------------EVSEQREYCPKCGKEKENQTKCQSCGIVFHNDLQ------RNCR 266

  Fly   860 ESETDSTDTG----TGFQAQNGKGFGAGRQPENSFLSQKR---RNQEENPRLIKYRRVDNSFPRL 917
            ::.|.:..||    |.....:|     |::.:|:.|:.|:   .:.::.|..|.....|:....:
Mouse   267 QAVTLNEPTGPLLRTSIHQNSG-----GQKSQNTGLTAKKFYGNSVDKIPIDILVTCDDSRHNYI 326

  Fly   918 ITNETAEDLIPNNSMAKRDQPQSSK-RLSIFNPPVYTQHRVRNDAPHVPTPFDDEESSQRLANAG 981
            .||  .:.::|...:.|...|:..| .:|..|.|:.           :.:..||::..:......
Mouse   327 QTN--GKVILPGGKIPKLTNPKERKISVSDLNDPII-----------LSSDDDDDDDDRTKRRES 378

  Fly   982 PSSRPMTYSDAVRLGHNGISESRVNGHSSHTVRREP------SRLHRSILSHEMNCKDQEQYNEL 1040
            .|.:|...:.:..:...|..|:.:|..:.. ..:||      ..|:..::..:...|||
Mouse   379 TSPKPADSACSSPVPSTGKVEAALNADACR-AEQEPRSSPAEPELNTIVIPRKARMKDQ------ 436

  Fly  1041 IRTQTNYVGSRYLKPGTPPTFQRAKAQSATS----SSCSLQDNQSNITDSFPSPHGRANPELTEY 1101
                   :|:....|     .:|.|..|..:    .|.|.|:.:|.|.:.      |:....|.:
Mouse   437 -------LGNSISTP-----LKRRKVNSHAAFIHPMSLSCQNFESVILNC------RSIRVGTLF 483

  Fly  1102 AKLINRQENEENRSPAPQQPKRNASNSSASHASTISSSA------SSSCSTCSTCSSSDTEPMLV 1160
            ..|:              :|...:..|...|.....|..      :|..:.|..|:......:.:
Mouse   484 RLLV--------------EPVIFSLESITIHLDGPESDPVDIILNTSDLTKCEWCNVRKLPVVFL 534

  Fly  1161 KDSPEV-----------KEANEANEANEANEANETKEN----------DAPQPTT---------T 1195
            :..|.|           ||....|:....|.....:|.          |......         .
Mouse   535 QAIPAVYQKLSMQLQMSKEDKVWNDCKGINRITSLEEQYIILIFQTGLDHQAEVVFESIITDIGI 599

  Fly  1196 RIKKPDFLHRRFANCIFLRNDFAENFKARANRRQLESMHLLGIAEQQANESKDERLAYEKKL--- 1257
            |...|:|    ||..:|   |.|.:......|...||  :.|...|:  |:|.:.:::|.|:
Mouse   600 RNNVPNF----FAKILF---DEANSRLVACTRSYEES--IKGNCAQK--ENKVKTVSFESKIQLR 653

  Fly  1258 --REVMF-----RSGAPHRPFFEIGPLEQPEEKKETKLIPLTKEDHARFQEMTTIEVTTNLIF-- 1313
              :|:.|     .:|..|..|  |||:|        |||                      ::
Mouse   654 SKQELQFFDDDEEAGESHTIF--IGPVE--------KLI----------------------VYPP 686

  Fly  1314 ---KYNLQITTDDIFTFVDGEWLNDAIINFYMSMLT-ERSEKRAGELPATYAMNTFFMPRL---- 1370
               |..:.:|.:|:....:||:|||.||:||:..|. |:.:|.  :....:..::||..||
Mouse   687 PPAKGGISVTNEDLHCLSEGEFLNDVIIDFYLKYLVLEKLKKE--DADRIHIFSSFFYKRLNQRE 749

  Fly  1371 -----------LQAGYAGVRRWTRKVDLFSKDIIPVPVHCGNVHWCMAII 1409
                       .|..:..|:.|||.||:|.||.|.||:: ...||.:|::
Mouse   750 RRNPETTNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLN-EAAHWFLAVV 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ulp1	NP_573362.1	Ehrlichia_rpt	200..>580	CDD:118064	1/3 (33%)
Ulp1	NP_573362.1	Peptidase_C48	1331..1506	CDD:280975	31/95 (33%)
Senp6	NP_001298039.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..51		3/27 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..395		11/71 (15%)
		Protease	693..1139		34/109 (31%)
		Peptidase_C48	707..>819	CDD:304959	31/95 (33%)
		Peptidase_C48	<999..1075	CDD:304959
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810