Protein Alignment Mec2 and nphs2

DIOPT Version :10

• Sequence 1: NP_573357.1
• Gene: Mec2 / 32905
• FlyBaseID: FBgn0030993
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: XP_017949096.1
• Gene: nphs2 / 100498000
• XenbaseID: XB-GENE-485101
• Length: 376
• Species: Xenopus tropicalis
• Alignment Length: 295
• Identity: 131/295 - (44%)
• Similarity: 188/295 - (63%)
• Gaps: 16/295 - (5%)

  Fly    47 TTQQYRGFKTSENEPKG--CMEWVVTLFSVLIFIITSPIAIFICFKVVAEYERAIIFRLGR-LSG 108
            |:|:..|.|     |.|  ..|.::....:|:.|:|.|::|:.|.|||.|||||:|||||| |||
 Frog    80 TSQKDDGVK-----PAGFRVFEGLLIFCCLLLVILTLPLSIWFCVKVVREYERAVIFRLGRMLSG 139

  Fly   109 GARGPGMFFILPCIDEYRKVDLRTVTFNVPQQEMLTKDSVTVTVDAVVYYRISDPLYAVIQVEDY 173
            .|||||:||.|||:|:..|||.|..||.||..:::|||.||:.:|.:.|||:.:....:..|...
 Frog   140 RARGPGLFFYLPCLDKCHKVDFRLKTFEVPFHQIVTKDLVTLEIDVICYYRLENACLFLTSVSSI 204

  Fly   174 SMSTRLLAATTLRNIVGTRNLSELLTERETLAHNMQATLDEATEPWGVMVERVEIKDVSLPVSMQ 238
            |.:.:||..||.:.::..|...::|.||:::...::..||.||..||:.|||.|||||.||..::
 Frog   205 SSAFQLLVQTTTKRLLAHRAFLDILLERKSIGEEVKVALDAATCHWGIKVERTEIKDVKLPEEVK 269

  Fly   239 RAMAAEAEAARDARAKVIAAEGEKKSATALKEASDVISASPSALQLRYLQTLSSISAEKNSTIIF 303
            ::||.||||.|.|:.|||||||||..:..:|.|::.:|.||:|:|||||.||..:::||.:|.:.
 Frog   270 QSMAVEAEAQRHAKVKVIAAEGEKTVSEYIKLAAEKLSGSPTAIQLRYLHTLQCMTSEKPATFVL 334

  Fly   304 PLPMELLTPYLAKYAHLMGPPPELKQSPE--KSDN 336
            |||.:|:.  |...|.|    ||:..:|.  ||||
 Frog   335 PLPFDLMN--LNAVARL----PEINPTPNTPKSDN 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mec2	NP_573357.1	SPFH_like	107..314	CDD:473137	93/206 (45%)
nphs2	XP_017949096.1	SPFH_podocin	116..338	CDD:259809	107/221 (48%)