DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7556 and Dnajc2

DIOPT Version :9

Sequence 1:	NP_001285427.1	Gene:	CG7556 / 32902	FlyBaseID:	FBgn0030990	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_446228.2	Gene:	Dnajc2 / 116456	RGDID:	620524	Length:	621	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	138/566 - (24%)
Similarity:	230/566 - (40%)	Gaps:	154/566 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ELEIFDLVEEV------NRNFYEFMGINQT---ATGAEVKRAFRTLSIVLHPDKNPA------ED 76
            :||.|.:::.:      |::.|..:|:...   ||..::|.|.:|:.:..||||..|      |.
  Rat    69 QLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAAHKTMVLKHHPDKRKAAGEPIKEG 133

  Fly    77 ANIQFRNLVSIYEVLKDPSRREKY---DRVLKEGMPNWKSALYYY-----------------RRM 121
            .|..|..:...||:|.||.:|..:   |......:|:...|...:                 :.:
  Rat   134 DNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKENFFQVFSPVFERNSRWSNKKNV 198

  Fly   122 RKIGLYEGAFILFLITTVGQYLFAW--------AAYLEKKYTAEQVFGTKLKKLQKKNKNIDMDV 178
            .|:|....:|     ..|..:...|        .:||:::...:.....:.|.::|:|:......
  Rat   199 PKLGDMNSSF-----EDVDAFYSFWYNFDSWREFSYLDEEEKEKAECRDERKWIEKQNRATRAQR 258

  Fly   179 ILSEIPMPSLLNTLPIQIPLALWNLPR-------------TIKNGFSKANELKELALEKRRQ-EL 229
            ...|      :|.:...:..|....||             ..|...::|...::.|.||:|| ||
  Rat   259 KKEE------MNRIRTLVDNAYSCDPRIKKFKEEGKAKKEAEKRAKAEARRKEQEAKEKQRQAEL 317

  Fly   230 EAVR-RQEELEREAEEQARLRKEHKENLRK--RKQNSK--------------------------- 264
            |||| .:|:.|.|..:||.|.|:.||..:|  :|:..|
  Rat   318 EAVRLAKEKEEEEVRQQALLAKKEKEIQKKAIKKERQKLRNSCKNWNHFSDNEADRVKMMEEVEK 382

  Fly   265 ---------------------------APEKTEEELRGYSQIQTRELTDDDA-VRPAS---QKST 298
                                       |.||..||:   :::..:|..:.|| :|.||   :|||
  Rat   383 LCDRLELASLQCLNEILASSTREVGKAALEKQIEEV---NELMRKEKEEADARMRQASKNAEKST 444

  Fly   299 VSGGF----WTDEDLTELIRLVKKYPGGAGSRWNTIAESMN--------RSVQEVTFMAAKMKEN 351
            ...|.    |:::||..||:.|..:|.|..|||..||..||        |:.::|...|..:::.
  Rat   445 GRSGSGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKL 509

  Fly   352 GYRIPGQTDSVAEALVQESQQAQRKEKVKKAAANAGASAEK--SMLIPETNWTQEQQRALEAAIV 414
            .   |.|.|.:.:....:.    :||......|::.|.:|:  ...|....||.|:|:.||.|:.
  Rat   510 D---PHQKDDINKKAFDKF----KKEHGVAPQADSAAPSERFEGPCIDSIPWTTEEQKLLEQALK 567

  Fly   415 KYRKTAGGDRWQKIANSVPEKTKEECLVRYKYLCELVKTQKRAEEE 460
            .|.... .:||:|||.:||.:||::|:.|||.|.|:||.:|.|:|:
  Rat   568 TYPVNT-PERWEKIAEAVPGRTKKDCMRRYKELVEMVKAKKAAQEQ 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7556	NP_001285427.1	DnaJ	40..101	CDD:278647	21/72 (29%)
		SANT	301..>341	CDD:197842	17/51 (33%)
		SANT	304..341	CDD:238096	16/44 (36%)
		SANT	399..447	CDD:197842	21/47 (45%)
		SANT	400..447	CDD:238096	21/46 (46%)
Dnajc2	NP_446228.2	DnaJ	88..158	CDD:278647	21/69 (30%)
		ZRF1-UBD	160..250		11/94 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..312		4/24 (17%)
		GBP_C	<288..353	CDD:303769	24/64 (38%)
		RAC_head	349..420	CDD:293322	7/73 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..453		9/26 (35%)
		SANT	452..508	CDD:197842	18/55 (33%)
		SANT	453..506	CDD:238096	18/52 (35%)
		SANT	553..602	CDD:197842	22/49 (45%)
		SANT	553..600	CDD:238096	21/47 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810