Protein Alignment HSD11B1 and CG31937

DIOPT Version :10

• Sequence 1: NP_005516.1
• Gene: HSD11B1 / 3290
• HGNCID: 5208
• Length: 292
• Species: Homo sapiens
• Sequence 2: NP_608616.2
• Gene: CG31937 / 326177
• FlyBaseID: FBgn0031360
• Length: 321
• Species: Drosophila melanogaster
• Alignment Length: 267
• Identity: 71/267 - (26%)
• Similarity: 116/267 - (43%)
• Gaps: 60/267 - (22%)

Human     1 MAFMKKYLLPILGLFMAYY-------------YYSANEEFRPEMLQGKKVIVTGASKGIGREMAY 52
            |:|: ::||.:|.|:...|             :|.:........::|:.|.:||||.||||.:|.
  Fly     1 MSFL-EFLLLLLVLYYVVYVLLWILLDCNVALWYKSRFGVSLSSMRGQVVWITGASSGIGRALAL 64

Human    53 HLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLI 117
            .||:.|..:|::||..|.|::|...||    |:|..:..|.:.:...             :|||.
  Fly    65 SLARHGVKLVLSARRLEQLEQVQEECL----AAARGLLATKDVLVIQ-------------MDMLD 112

Human   118 LN-HIT--NTSLNLFHD-------------------DIHHVRKSMEVNFLSYVVLTVAALPMLKQ 160
            |: |.|  ||.||.||.                   :|...|:..|::..:.|.|:...:....:
  Fly   113 LDEHKTHLNTVLNHFHRLDVLVNNAGRSQRASWTEVEIEVDRELFELDVFAVVHLSRLVVRYFVE 177

Human   161 SNGS---IVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTET 222
            .||.   |...||:||....|....|.|:|.||:.:..|::.|..    .:.::|...|.|.|:.
  Fly   178 QNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLSLKVEMR----KLDVSLFAPGPIATDF 238

Human   223 AMKAVSG 229
            ..:|.:|
  Fly   239 LQEAFTG 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD11B1	NP_005516.1	11beta-HSD1_like_SDR_c	32..279	CDD:187593	63/223 (28%)
CG31937	NP_608616.2	Rossmann-fold NAD(P)(+)-binding proteins	44..293	CDD:473865	63/223 (28%)