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Protein Alignment HSD11B1 and CG31937

DIOPT Version :9

Sequence 1:	NP_005516.1	Gene:	HSD11B1 / 3290	HGNCID:	5208	Length:	292	Species:	Homo sapiens
Sequence 2:	NP_608616.2	Gene:	CG31937 / 326177	FlyBaseID:	FBgn0031360	Length:	321	Species:	Drosophila melanogaster

Alignment Length:	267	Identity:	71/267 - (26%)
Similarity:	116/267 - (43%)	Gaps:	60/267 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAFMKKYLLPILGLFMAYY-------------YYSANEEFRPEMLQGKKVIVTGASKGIGREMAY 52
            |:|: ::||.:|.|:...|             :|.:........::|:.|.:||||.||||.:|.
  Fly     1 MSFL-EFLLLLLVLYYVVYVLLWILLDCNVALWYKSRFGVSLSSMRGQVVWITGASSGIGRALAL 64

Human    53 HLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLI 117
            .||:.|..:|::||..|.|::|...||    |:|..:..|.:.:...             :|||.
  Fly    65 SLARHGVKLVLSARRLEQLEQVQEECL----AAARGLLATKDVLVIQ-------------MDMLD 112

Human   118 LN-HIT--NTSLNLFHD-------------------DIHHVRKSMEVNFLSYVVLTVAALPMLKQ 160
            |: |.|  ||.||.||.                   :|...|:..|::..:.|.|:...:....:
  Fly   113 LDEHKTHLNTVLNHFHRLDVLVNNAGRSQRASWTEVEIEVDRELFELDVFAVVHLSRLVVRYFVE 177

Human   161 SNGS---IVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTET 222
            .||.   |...||:||....|....|.|:|.||:.:..|::.|..    .:.::|...|.|.|:.
  Fly   178 QNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLSLKVEMR----KLDVSLFAPGPIATDF 238

Human   223 AMKAVSG 229
            ..:|.:|
  Fly   239 LQEAFTG 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSD11B1	NP_005516.1	11beta-HSD1_like_SDR_c	32..279	CDD:187593	63/223 (28%)
CG31937	NP_608616.2	Rossmann-fold NAD(P)(+)-binding proteins	44..293	CDD:473865	63/223 (28%)

Information from Original Tools:

Software error:

Can't use an undefined value as an ARRAY reference at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 1034.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-
Hieranoid	0	0.000	Not matched by this tool.