DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htk and ECM5

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_013901.1	Gene:	ECM5 / 855214	SGDID:	S000004788	Length:	1411	Species:	Saccharomyces cerevisiae

Alignment Length:	292	Identity:	60/292 - (20%)
Similarity:	118/292 - (40%)	Gaps:	70/292 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 EVVNEKE------ENIGKVVCVETESKKKDK-EKW----------------------FPALVVAP 201
            |.||||.      ....|:..:|.|.:::.. ::|                      |.:...||
Yeast    16 EPVNEKVMVQNGFHESSKIADIELEIQERPSIKQWESPRSAVIPTSNHNFSPFLYTQFKSRGAAP 80

  Fly   202 TAQATVR----IRVKDEYLVRSF--KDGRYYTVPKKEATEFTREVASKQDVPAVQAALEFLDSSV 260
            .|..|::    :.:.:....|.|  |.|.:|.:.......|   :.:|:::|......|.::
Yeast    81 FAPETIKSVDLVELPEGVPARVFHEKTGLFYQISPHSIPTF---ILAKKELPDPIKFYELVE--- 139

  Fly   261 LPAHWDRDSLFGLTNISSDDEGE------IDSD-----------SSDDEPHEEKDRFVAQLYKYM 308
                 |..|::|...:....:.:      :|.|           :|::....:...|.|:||.:.
Yeast   140 -----DLGSVYGCVKLKIIPDADKFTQLNVDVDRLWFKARKQFFNSNEFQRTKIVDFYAKLYNFH 199

  Fly   309 DD-RGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNL-VK 371
            :. :.:.|.::|||..|.:|||||...|:.|||:|.|..:..|..|...||::...:|.::. ::
Yeast   200 NKIKKSTLTRIPSIDKRTLDLYRLRSCVKLRGGFNAVCEKKLWAQIGRELGYSGRIMSSLSTSLR 264

  Fly   372 QAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSK 403
            .||.|.|..:..:..:     ...:||:.:::
Yeast   265 SAYAKILLDFDIYEEE-----EQAARNNEKNE 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	19/125 (15%)
		ARID	299..381	CDD:279697	29/83 (35%)
		Tudor-knot	692..751	CDD:288553
ECM5	NP_013901.1	BRIGHT	187..280	CDD:128777	29/92 (32%)
		cupin_RmlC-like	512..662	CDD:424065
		PHD_Ecm5p_Lid2p_like	1240..1287	CDD:276993
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940