Protein Alignment htk and Arid4b

DIOPT Version :10

• Sequence 1: NP_573330.3
• Gene: htk / 32877
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_008769986.1
• Gene: Arid4b / 84481
• RGDID: 619919
• Length: 1319
• Species: Rattus norvegicus
• Alignment Length: 1449
• Identity: 396/1449 - (27%)
• Similarity: 605/1449 - (41%)
• Gaps: 367/1449 - (25%)

  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:.:|:||.|.|||:|||||:|||||||:....|.:||||.::....:..|.||.||.|   |:|
  Rat     1 MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGP---LKV 62

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            ||:|||::.| ....||.|.|:.|.|.|||||||||..||||::||||..|||.|||||||||||
  Rat    63 GAIVEVKNLD-GAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLT 126

  Fly   131 HPEHFGNPVVGGR--RGRRRGHLNED----SSEDDDESDAKEVVNEKEENIGKVVCVETESKKKD 189
            :|||||.||:|.:  ||||..|:.|:    ||.||||.|.|:.    :|.:||||||:..|..|.
  Rat   127 NPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEDDRKQT----DELLGKVVCVDYISLDKK 187

  Fly   190 KEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDVPAVQA--- 251
            |..|||||||.|.....:.:: ||..||||||||::.:||:|:..|.|.:.|.|.|....||
  Rat   188 KALWFPALVVCPDCSDEIAVK-KDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFDQ 251

  Fly   252 ALEFLDSSVLPAHWDRDSLFGLTNISSDDEGEIDSDSSDDEPH----------------EEKDRF 300
            ||||..|..:||:|..:    |...||..|.|.:.:..|||..                ||::.|
  Rat   252 ALEFHKSRTIPANWKTE----LKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENF 312

  Fly   301 VAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVS 365
            :.||||:|:|||||:||.|.:..|:::|::|||.|.|.||::.:.|...||.:...||     :.
  Rat   313 LQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLG-----IP 372

  Fly   366 VMNL-----VKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRANSVASP-----KPME 420
            |:|.     ||.||||:|..:.::.|.......|                   |.|     ||.:
  Rat   373 VLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQM-------------------ALPEKVLNKPCK 418

  Fly   421 TMKTETI----SKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVV 481
            ..:.:.|    ...|:..:.||..|.:      .:....|||.              :.||....
  Rat   419 DCENKEIKVKEESDAEIKEVNVEDSKN------MIPKEETPAE--------------DESERKEN 463

  Fly   482 VEPPKKQRKGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTAT 546
            ::|....:||            |:|                           .:|..|
  Rat   464 IKPSLGSKKG------------LLE---------------------------CIPAQS------- 482

  Fly   547 NLSSATSGGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANS 611
                                |.|.:..:.|::        .:.|:|.:...::.:..:.|::.::
  Rat   483 --------------------DQEKEANITKLE--------EKESLEDKDGATARAEEALSTEVDA 519

  Fly   612 AEMQ-RSRDASPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKR 675
            .|.| ||.|                         ...||:.:..::.::|:::|:||.:......
  Rat   520 EEEQARSGD-------------------------ETNKEEDEDDEEIEEEEEEDEEEDEDEDDDD 559

  Fly   676 KKEKISVEKIDTGDFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNN 740
            ..|:...|....       |.|::|.|...|:.    ..|||.:.:..|:.|..:|||||.|||.
  Rat   560 NNEEEEFECYPP-------GMKVQVRYGRGKNQ----KMYEASIKDSDVEGGEVLYLVHYCGWNV 613

  Fly   741 RYDEWVPRERIAENLTKG--------------SKQKTRTISTSSANSGSGGGGGGGGGGGGGGGG 791
            |||||:..::|.....|.              .|:|.|....|..|
  Rat   614 RYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKN------------------- 659

  Fly   792 GGGSLLVQGSQPPGVSDKQPGKDGCSKMSPSSGNSTGPG---APSLSGSLGGASSTPSLLSTVVK 853
               ..|.:.|:.|..|:  |..:..||:..:...::..|   :..::..|.|..::.|
  Rat   660 ---CKLRRLSKSPFQSN--PSPEMVSKLDLADAKNSDTGHIKSIEITSILNGLQASES------- 712

  Fly   854 TPPTGGAKRGRGRSDSMPPRSTTPSSVVAHSGRTKSPAASQ-----PQLQQQMKKRPTRVVPGTT 913
              ....:::...|....|..|:...|.|.||..::|...|:     |.|.::.|..|..|:..|.
  Rat   713 --SAEDSEQEEERCAQDPESSSKDESKVEHSAHSRSELISKEELSSPSLLEENKVHPDLVIAKTV 775

  Fly   914 --TPRRV-SDASMASE-SDSDSDEPVRRPKRQSAKD------KPQA--GK---------AQPPGK 957
              :|.|: .|....|| :|.:.::.:.:.::...||      |||.  ||         .|....
  Rat   776 SKSPERLRKDVEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCNTDECLQSGSP 840

  Fly   958 GRLASSASSTAP-AAHPSDDSEEDEEEEEPSAARAASSKQQ---QQQASSLRG-------SRAGG 1011
            |:......|..| ....|.:|..||:|||.|.|:...:|:.   :::..|||.       |....
  Rat   841 GKKEDRTKSKEPLCTGNSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAE 905

  Fly  1012 NRAM---SSGAASAKGRDYDLSEIRSELKGFQPKLLTNAASNEERKDLAKKEPSDEP-------A 1066
            .|..   :|.......|..|..::.|.::|..||.......::...:.|...|...|       :
  Rat   906 KRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHAAPDEGTVEES 970

  Fly  1067 LQDIKKEPKLESSAKSSSTE----LSSETESYADEDSQSSDYRKQLKGSGAG---KKEPTA--SP 1122
            ||.:.:|   ||.:.:...|    .|.:::...::..:.||.:.:...||:.   ...||.  ||
  Rat   971 LQTVAEE---ESCSPNMELEKPLPTSVDSKPVEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESP 1032

  Fly  1123 SKLHHEPVTKRELAVKEEPLKIEPKTEPKEEETKSKPFLSGADIKPTALIAPAR----FGNTSAA 1183
            |.     ||..|.:.::..:.:.....|.:||.:|....:.:.|:..:::...:    .||:|.|
  Rat  1033 SS-----VTVTETSQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPA 1092

  Fly  1184 ---QAASSSGSSSTTAKYTSVIVEKPLTIGGKKSVEQHVPKKAELLKKQSGGAGGTAASSSAASQ 1245
               .:.|||.|:....::.    ||..|  |:|.|            |.:.|.|    |||...:
  Rat  1093 GFNASVSSSSSNQPEPEHP----EKACT--GQKRV------------KDTQGVG----SSSKKQK 1135

  Fly  1246 ESKKFAEPVASLKVEMPAACSPSSSSSSSSSFCSTGSAVSSSSATRSLPDMSKLEISSGTVPGAT 1310
            .|.| |..|.:.|       ....::||.|...|.|.:|:.:.|.:|:|...|...|.......:
  Rat  1136 RSHK-ATVVNNKK-------KGKGTNSSDSEDLSAGESVTKTQAIKSVPTGMKTHNSKSPARIQS 1192

  Fly  1311 PGAAA---------LQPSN 1320
            ||...         .:|||
  Rat  1193 PGKCGKNGDKDPDLKEPSN 1211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	Tudor_ARID4_rpt1	10..60	CDD:410460	26/49 (53%)
		Tudor_ARID4_rpt2	65..118	CDD:410461	31/52 (60%)
		RBB1NT	170..263	CDD:462390	43/95 (45%)
		ARID	296..381	CDD:460187	38/89 (43%)
		CBD_RBP1_like	698..758	CDD:350843	22/59 (37%)
Arid4b	XP_008769986.1	Tudor_ARID4B_rpt1	1..61	CDD:410531	31/62 (50%)
		Tudor_ARID4B_rpt2	62..118	CDD:410533	34/56 (61%)
		RBB1NT	168..263	CDD:462390	43/99 (43%)
		ARID_ARID4B	308..399	CDD:350647	38/95 (40%)
		CD_CSD	573..630	CDD:475127	23/60 (38%)