Protein Alignment htk and ARID5B

DIOPT Version :10

• Sequence 1: NP_573330.3
• Gene: htk / 32877
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: NP_115575.1
• Gene: ARID5B / 84159
• HGNCID: 17362
• Length: 1188
• Species: Homo sapiens
• Alignment Length: 1241
• Identity: 233/1241 - (18%)
• Similarity: 390/1241 - (31%)
• Gaps: 421/1241 - (33%)

  Fly   100 GDITTLRRT---ALCL---------KSGRHFNESETLDQLPLTHPEHFGNPVVGGRRGRRRGHLN 152
            ||...:|.|   .:|:         ::.|....|..|..||...|:           ||     |
Human    39 GDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQ-----------GR-----N 87

  Fly   153 EDSSEDDDESDAKEVVNEKEE-------NIGKVVC------VETESKKKDKEKWFPALVVAPTAQ 204
            .|..||:..:.:::|:.:.|:       :..|..|      |:||:..::.:|  .||:....:.
Human    88 SDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGFHAGPVKTEALGRNGQK--EALLKYRQST 150

  Fly   205 ATVRIRVKD---------------EYLVRSFKD-GRYYTVPK----KEATEFTRE---------V 240
            ....:..||               ..:|.|:.. .||.::.|    |.::..|.:         |
Human   151 LNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAV 215

  Fly   241 ASKQDVPAVQAALEFLDSSVL----------------------PAHWDRDSLFGLTNISSDDEG- 282
            .|:.  |.:....:..|...|                      |....|||..|:.:.:::.:|
Human   216 VSRN--PQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSDGK 278

  Fly   283 -----EIDSDSSDDEP----------HEEKDR-------------FVAQLYKYMDDRGTPLNKVP 319
                 :.::.|:..:|          :|||.:             |:..|||||.:|.||:.::|
Human   279 AVAKVKCEARSALTKPKNNHNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIP 343

  Fly   320 SILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDF 384
            .:..:.::|:.:|:|.||.|||..:|::.|||.|...||..|.:.|.....::.|::.:.||..|
Human   344 YLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERF 408

  Fly   385 HRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTETISKLAQPNQTNVVASTSS----- 444
                             .||.         ..||:..:|.......:|.|:.....|.:.
Human   409 -----------------IKGE---------EDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHE 447

  Fly   445 -SAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRKGSAASSQQGKVKSLVEKY 508
             ..:......:..|..|...:|:...|:....|:.|:....|....|......|:...|.|..:.
Human   448 IPKSKKEKENAPKPQDAAEVSSEQEKEQETLISQKSIPEPLPAADMKKKIEGYQEFSAKPLASRV 512

  Fly   509 E-EKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSGGSATIATTAMNKDAESDL 572
            : ||.......|:.......|.......|..||
Human   513 DPEKDNETDQGSNSEKVAEEAGEKGPTPPLPSA-------------------------------- 545

  Fly   573 PLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANS--AEMQRSRDASPSVAAPPSAGASTS 635
            |||..|.:|:...:::..:       :..||...||..|  .....|.::.|..|:.||...:..
Human   546 PLAPEKDSALVPGASKQPL-------TSPSALVDSKQESKLCCFTESPESEPQEASFPSFPTTQP 603

  Fly   636 GAAATAQTASNK--------------------KEKHQRSKQA---------DKEKDKDKEEKQAS 671
            ..|...:|..:|                    .:.|...||.         |..||||.
Human   604 PLANQNETEDDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDKDL------ 662

  Fly   672 SGKRKKEKISVEKIDTGDFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYT 736
                           ||..                 ..:||..|    ..:...||.|
Human   663 ---------------TGPM-----------------NENHGLNY----TPLLYSRGNP------- 684

  Fly   737 GWNNRYDEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGS 801
                         .|...|.|  |:....:|.:|.:|.                      ...||
Human   685 -------------GIMSPLAK--KKLLSQVSGASLSSS----------------------YPYGS 712

  Fly   802 QPPGVSDKQ--PGKDGCSKMSPS-SGNSTGPGA---PSLSGSLGGASSTPS----LLSTVVKTPP 856
            .||.:|.|:  ...|.||.:|.: .|.||...|   ||:...:....|.||    .::.:.|
Human   713 PPPLISKKKLIARDDLCSSLSQTHHGQSTDHMAVSRPSVIQHVQSFRSKPSEERKTINDIFK--- 774

  Fly   857 TGGAKRGRGRSDSMPPRSTTPSSVVAHSGRTKSPAASQPQLQQQM-----KKRPTRVVPGTTTPR 916
                .....|||  |.|       .:.|....:|.|....|:|::     |....|.:|.:..|.
Human   775 ----HEKLSRSD--PHR-------CSFSKHHLNPLADSYVLKQEIQEGKDKLLEKRALPHSHMPS 826

  Fly   917 RVSDASMAS-------------ESDSDSDEPVRRPKRQSAKDKPQAGKAQPPGKGRLASSA---- 964
            .::|...:.             .::..|..|.|...|:|......:.:.|........:|.
Human   827 FLADFYSSPHLHSLYRHTEHHLHNEQTSKYPSRDMYRESENSSFPSHRHQEKLHVNYLTSLHLQD 891

  Fly   965 SSTAPAAHPSDDSEED----EEEEEPSA-----ARAASSKQQQQQASSLR--GSR---------- 1008
            ..:|.|..|:||...|    :...:|:.     |.:.:..|:.:..|..:  ||:
Human   892 KKSAAAEAPTDDQPTDLSLPKNPHKPTGKVLGLAHSTTGPQESKGISQFQVLGSQSRDCHPKACR 956

  Fly  1009 ------AGGNRAMSSGAASAKGRDYDLSEIRSELKGFQPKLLTNAASNEERKDLAKKEPSDEPAL 1067
                  :|..:...|.:.|.|.....|...| :::|....:|..           |..|.:..|.
Human   957 VSPMTMSGPKKYPESLSRSGKPHHVRLENFR-KMEGMVHPILHR-----------KMSPQNIGAA 1009

  Fly  1068 QDIKKE----------------PKLESSAKSSSTELSSETESYADEDSQSSDYRKQLKGSGAGKK 1116
            :.||:.                ..|:.|.:.|..|.:||.||   |.|::: :.....|...|.|
Human  1010 RPIKRSLEDLDLVIAGKKARAVSPLDPSKEVSGKEKASEQES---EGSKAA-HGGHSGGGSEGHK 1070

  Fly  1117 EPTASP 1122
            .|.:||
Human  1071 LPLSSP 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	Tudor_ARID4_rpt1	10..60	CDD:410460
		Tudor_ARID4_rpt2	65..118	CDD:410461	6/29 (21%)
		RBB1NT	170..263	CDD:462390	23/156 (15%)
		ARID	296..381	CDD:460187	30/97 (31%)
		CBD_RBP1_like	698..758	CDD:350843	8/59 (14%)
ARID5B	NP_115575.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..277		5/25 (20%)
		ARID_ARID5B	320..414	CDD:350649	33/119 (28%)
		PTZ00121	<410..>536	CDD:173412	23/134 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	412..611		40/246 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	846..874		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	891..918		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	956..978		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1028..1070		12/45 (27%)