Protein Alignment htk and arid4a

DIOPT Version :10

• Sequence 1: NP_573330.3
• Gene: htk / 32877
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_012824464.2
• Gene: arid4a / 733818
• XenbaseID: XB-GENE-983782
• Length: 1309
• Species: Xenopus tropicalis
• Alignment Length: 1450
• Identity: 382/1450 - (26%)
• Similarity: 570/1450 - (39%)
• Gaps: 392/1450 - (27%)

  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:..|:|..|.|||:|||||:|||||||:..|.|.:||||..||...:.:|.||.:|.|   |||
 Frog     1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVTLKQDNSTQLVQDDQVKGP---LRV 62

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            ||.||::..|... .||.|:|:.|.|.|||||||||..|||||:||||..|||.|||||||||||
 Frog    63 GATVEMKTTDGSP-QEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLT 126

  Fly   131 HPEHFGNPVVGGR--RGRR------RGHLNEDSSEDDDESDAKEVVNEKEENIGKVVCVETESKK 187
            :|||||.||:|.:  ||||      .....|:|||::|| |.|.:   .:|.:||:|.|:. |..
 Frog   127 NPEHFGTPVIGKKTNRGRRSSLPMTEDEKEEESSEEEDE-DLKRL---NDELLGKIVSVQC-SLP 186

  Fly   188 KDKEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDV--PAVQ 250
            ||   ||.||||:|:......:: ||:.|||||.|.::::|.:|:.||....|.:.:..  ..||
 Frog   187 KD---WFTALVVSPSCSDDASVK-KDQCLVRSFVDSKFHSVARKDLTEVDVNVLNSEHFGKQGVQ 247

  Fly   251 AALEFLDSSVLPAHWDRDSLFGLTNISSDDE-GEIDSDSSDD--------EPHE-----EKDRFV 301
            .|:.||.|..:|..|..|....|.:.|||:| ||.|:..||.        ||.|     |:|.|:
 Frog   248 DAIAFLISKTIPEKWKMDMNEILESSSSDEEDGEDDACDSDQNKEEEVETEPEEEADPAERDIFL 312

  Fly   302 AQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSV 366
            .||||:|:|||||:||.|.:..:|::|::|||.|.::||.:.:.|...||.|.|.||......:.
 Frog   313 QQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYQQGGCDNIESGAVWKQIYMDLGIPILNSAA 377

  Fly   367 MNLVKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTETISKLA 431
            ...||.||||:|..:.::.|...........|                .|||:|..|.|
 Frog   378 SYNVKTAYKKYLYGFEEYCRSANIQFRTIHHN----------------DPKPIEEPKVE------ 420

  Fly   432 QPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRKGSAASS 496
                                             .:...|.|.....:|.:::...|:...|.:||
 Frog   421 ---------------------------------EEKPMESSEQKETASPLLDAKMKEEDESDSSS 452

  Fly   497 QQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSGGSATIAT 561
            :.||        ||..|.:::.     .|....|..|....|....|.....::..
 Frog   453 EYGK--------EETETEMKSP-----RGRRRCAFNAFSVVTDVEDSDTRKDNNKE--------- 495

  Fly   562 TAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEMQRSRDASPSVAA 626
               |||.|.||               ..:.|||.:.|:....|...:|...:..:.:|.|
 Frog   496 ---NKDIEEDL---------------NKTEEKEEDESTPVRRSLQCRAKGDQKTKKQDES----- 537

  Fly   627 PPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISVEKIDTGDFV 691
                                       .:::|::.:|..|.|:.|..|.:.|:   |..||.|..
 Frog   538 ---------------------------ERESDEDDEKPCEGKEDSEHKGETEE---EDEDTEDRD 572

  Fly   692 VGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRYDEWVPRERIAENLT 756
            ...|.|:||.|...|:.    ..|||.:....|..|..:|||||.|||.||||||..:||.....
 Frog   573 YLAGTKVKVKYGRGKTQ----KIYEANIKSTEVDGGELLYLVHYYGWNVRYDEWVKADRIIWPSD 633

  Fly   757 KGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVSDKQPGKDGCSKMSP 821
            ||..:|.:...|.:.:.                                 ::::...|..||.
 Frog   634 KGGPKKKQKKKTKNKDE---------------------------------NEEKKEDDKRSKR-- 663

  Fly   822 SSGNSTGPGAPSLSGSLGGASSTPSLLSTVVKTPPTGGAKRGRGRSDSMPPRSTTPSSVVAHSGR 886
                    |.|.|.     ::...::...:.|||.:.|....:...:|:...|:..:.:
 Frog   664 --------GRPPLK-----SAHQTNMTCGLPKTPTSEGKTSVKNMRNSLSDSSSLSNGL------ 709

  Fly   887 TKSPAASQPQLQQQMKKRPTRVVPGTTTPRRVSDASMASESDSDSDEPVRRPKRQSAKDKPQAGK 951
                        :...:|.||...|.....|.|:.|..|||:||...     ::.|.|::....|
 Frog   710 ------------EGSARRRTRRSSGLYDSDRCSNDSSTSESESDETS-----EKASVKEEEVLPK 757

  Fly   952 AQPPGKGRLA-------------------SSASSTAPAAHPSDDSEEDEE------------EEE 985
            |:...:..|:                   ...|.|.||.....:.||.|:            ||.
 Frog   758 AEEEPENILSLVDISPVKEVPPVICLLKDPEHSPTKPAETLKQEVEESEQIVQIYGKQTEELEEI 822

  Fly   986 PSAARAASSKQQQQQASSLRGSRAGGNRAMSSGAASAKGRDY---------DLSEIRSELKGFQP 1041
            ..|.....||.::   |..:.|.....:.:|:.........:         .||.::|:...|.|
 Frog   823 KEAEHLPKSKGRR---SKTKDSSVENTKCLSATQEDTLVEPHVEEDTLDLPSLSPLQSKELPFTP 884

  Fly  1042 K--LLTNAASNEERKDLAKK--EPSDEPALQDIKKEPKLESSAKSSSTELSSETESYAD---EDS 1099
            |  .|.|....:|:|.|.:|  |.|........:.:|:|........||.::|.:.:.:   ||.
 Frog   885 KEAELPNDQLAQEKKGLKRKPLEQSSPDKKLRTECDPELPVIVAEEKTEENNEAQEHFNTIHEDE 949

  Fly  1100 QSSDYRKQLKGSGAGKKEPTASPSKLHHEPVTKRELAVKEEPLKIEPKTEPKEEETKSKPFLSGA 1164
            :..:..:::         |:.: ::|.|...|:.:  ..:.||          .|..:.|:....
 Frog   950 ELPNVNEEM---------PSLT-AELEHVHSTRTD--EFDIPL----------NEITNMPYQEDQ 992

  Fly  1165 DIKPTALIAPARFGNTSAAQAASSSGSSSTTAKYTSVIVEKPLTIGGKKSVEQ-----HVPKKAE 1224
            |..||       .|..:........|......|...:::||         |||     |.|....
 Frog   993 DTMPT-------IGPENLVCHEVDLGDFDEKDKVEDIVMEK---------VEQDTQTIHPPTLPP 1041

  Fly  1225 LLKKQSGGAGGTAASSSAASQESKKFAEPVASLKVEMPA------ACSPSSS----SSSSSSFCS 1279
            .::..|.......|.|...|...|  :|...:::|:..|      .|...|:    :|::||.||
 Frog  1042 AIQPHSYSVASPLALSHDESHSIK--SESDITIEVDSVAEESQEGLCESESANGFEASTTSSNCS 1104

  Fly  1280 -----------------------------------TGSAVSSSS--------ATRSLPDMSKLEI 1301
                                               |...:|:||        .:....|:|.|:.
 Frog  1105 VTAQEADITEKGNFITCHKRINESLSGSLAKKQKRTPKRISTSSKVEKNGIGQSSDSEDLSTLDT 1169

  Fly  1302 SSGTVPGATPGAAALQPSNV 1321
            ||...|...||  .|:|..:
 Frog  1170 SSKCTPIKHPG--VLKPQKI 1187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	Tudor_ARID4_rpt1	10..60	CDD:410460	28/49 (57%)
		Tudor_ARID4_rpt2	65..118	CDD:410461	31/52 (60%)
		RBB1NT	170..263	CDD:462390	34/94 (36%)
		ARID	296..381	CDD:460187	38/84 (45%)
		CBD_RBP1_like	698..758	CDD:350843	25/59 (42%)
arid4a	XP_012824464.2	Tudor_ARID4A_rpt1	4..61	CDD:410530	31/59 (53%)
		Tudor_ARID4_rpt2	62..114	CDD:410461	31/52 (60%)
		RBB1NT	170..260	CDD:462390	34/97 (35%)
		ARID	307..393	CDD:355778	38/85 (45%)
		PLN00104	524..>628	CDD:215056	39/142 (27%)
		CBD_RBP1_like	577..633	CDD:350843	26/59 (44%)