Protein Alignment htk and Arid5b

DIOPT Version :10

• Sequence 1: NP_573330.3
• Gene: htk / 32877
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_006514192.1
• Gene: Arid5b / 71371
• MGIID: 2175912
• Length: 1214
• Species: Mus musculus
• Alignment Length: 1186
• Identity: 228/1186 - (19%)
• Similarity: 393/1186 - (33%)
• Gaps: 353/1186 - (29%)

  Fly    23 AFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRVGAVVEVRHPDRKELVEATITKI 87
            |.|..:.|:|:| :::..|.....||....|:.|                     .:.|..|.|:
Mouse    90 ALCLPRQSRVIR-LRLLRAASSAPGSRAFEDEVI---------------------AVSEKVIVKL 132

  Fly    88 QDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLTHPEHFGNPVVGGRRGRRRGHLN 152
            :|    .|.:...|.:..|    |   |......:|         |.|      ||.|::...|.
Mouse   133 ED----LVKWAHSDFSKWR----C---GLRATPVKT---------EAF------GRNGQKEALLR 171

  Fly   153 EDSSEDDDESDAKEVVNEK------EENIGKVV------CVETESKKKDKEKWFPALVVAPTAQA 205
            ...|..:...:.|:|:.||      ||....:|      |......|:.::|  |:.::  |.|.
Mouse   172 YRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDK--PSSIL--TDQF 232

  Fly   206 TVRI-----------------------RVKDEYLVRSFK---DGRYYTVPKKEATEFTREVASKQ 244
            .:.:                       .:::|.:...|.   .||    |:|:.|...|
Mouse   233 ALALGGIAVVSRNPQILYCRDTFDHPTLIENESVCDEFAPNLKGR----PRKKKTCPQR------ 287

  Fly   245 DVPAVQAALEFLDSSVLPAHWDRDSLFGLTNISSDDEGEIDS----------------------D 287
                                  |||..|..:.:::.:|::.|                      .
Mouse   288 ----------------------RDSFSGSKDPNNNCDGKVISKVKGEARSALTKPKNNHNNCKKT 330

  Fly   288 SSDDEP--------HEEKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRV 344
            |::::|        ..::..|:..|||||.:|.||:.::|.:..:.::|:.:|:|.||.|||..:
Mouse   331 SNEEKPKLSIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETI 395

  Fly   345 TSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDF-------------HRKLGCSMLMTS 396
            |::.|||.|...||..|.:.|.....::.|::.:.||..|             .||...:   |.
Mouse   396 TARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENN---TQ 457

  Fly   397 RNSNRSK--GRSLVRANSVA-------SPKPMETMKT--------ETISKLAQPN-----QTNVV 439
            .|.|::|  |...::.....       :|||.:|.:.        ||::..:.|.     :....
Mouse   458 ENENKTKVSGNKRIKQEMAKNKKEKENTPKPQDTSEVSSEQRKEEETLNHKSAPEPLPAPEVKGK 522

  Fly   440 ASTSSSAAAASVAASSTPARAVST----ASQSAAEESGNTSESSVVVEPPKKQRKGSAASSQQGK 500
            ........|.:..:.:.|.:|..|    .|:..|||.|:...:.::..||....|.||.:...||
Mouse   523 PEGHKDLGARAPVSRADPEKANETDQGSNSEKEAEEMGDKGLAPLLPSPPLPPEKDSAPTPGAGK 587

  Fly   501 ------VKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSG--GSA 557
                  ...:..|.|.|......:....:.|:..|:.:|..|..::..........||:.  .:.
Mouse   588 QPLASPSTQMDSKQEAKPCCFTESPEKDLQGAPFSSFSATKPPLTSQNEAEEEQLPATANYIANC 652

  Fly   558 TIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNI-----------------SSGSSASA 605
            |:....:..|   |:..| :|............|.|:.::                 |.|:....
Mouse   653 TVKVDQLGSD---DIHTA-LKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIM 713

  Fly   606 SSKANSAEMQRSRDASPSVAAP---PSAGASTSGAAATAQTASNKKEKH--QRSKQADKEKDKDK 665
            |..|....:.:...||.|.:.|   |....|.....|.....|...:.|  |.|......:....
Mouse   714 SPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIAREDLCSGLSQGHHSQSSDHTAVSRPSVI 778

  Fly   666 EEKQASSGKRKKEKISVEKIDTGDFVVGIGDKLKVNYHEKKSPSSH--GSTYEAKVIEISVQRG- 727
            :..|:...|..:::.|:..|..       .|||..:...:...|.|  ||..::.:::...|.|
Mouse   779 QHVQSFKNKASEDRKSINDIFK-------HDKLSRSDAHRCGFSKHQLGSLADSYILKQETQEGK 836

  Fly   728 -------------VPMYLVHYTGWNNRYDEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGG 779
                         ||.:|..:....:.:..:...|....| .:.||...|.....|.|
Mouse   837 DKLLEKRAVSHAHVPSFLADFYSSPHLHSLYRHTEHHLHN-EQSSKYAARDAYQESEN------- 893

  Fly   780 GGGGGGGGGGGGGGGSLLVQGSQPPGVSDKQPGKDGCS---------KMSPSSGNSTGPGAPSLS 835
                          |:.|         |.|.|.|...:         |...::..||......||
Mouse   894 --------------GAFL---------SHKHPEKIHVNYLASLHLQDKKVAAAEASTDDQPTDLS 935

  Fly   836 GSLGGASSTPSLLSTVV--KTPPTGGAKRGRGRSD----SMPPRSTTPS----SVVAHSGRTKSP 890
                 ....|..|::.|  ....|.|::..:|.|.    |...|...|.    |.:..||..|.|
Mouse   936 -----LPKNPHKLTSKVLGLAHSTSGSQEIKGASQFQVVSNQSRDCHPKACRVSPMTMSGPKKYP 995

  Fly   891 -AASQPQLQQQMKKRPTRVVPGTTTP---RRVSDASMASESDSDSDEPVRRPKRQSAKDKPQ--A 949
             :.::.....|::....|.:.|...|   |::|..::.:          .||.::|.:|...  |
Mouse   996 ESLARSGKPHQVRLENFRKMEGMVHPILHRKMSPQNIGA----------ARPIKRSLEDLDLVIA 1050

  Fly   950 GKAQPPGKGRLASSASSTAPAAHPSDDSEEDEEEEEPSAARAASSKQQQQQASSLRGSRAGGNRA 1014
            ||               .|.|..|.|.::|...:|          |..:|::...:|:..|
Mouse  1051 GK---------------KARAVSPLDPAKEASGKE----------KASEQESEGNKGAYGG---- 1086

  Fly  1015 MSSGAASAKGRDYDLS 1030
             .||||| :|....||
Mouse  1087 -HSGAAS-EGHKLPLS 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	Tudor_ARID4_rpt1	10..60	CDD:410460	10/36 (28%)
		Tudor_ARID4_rpt2	65..118	CDD:410461	9/52 (17%)
		RBB1NT	170..263	CDD:462390	19/130 (15%)
		ARID	296..381	CDD:460187	28/84 (33%)
		CBD_RBP1_like	698..758	CDD:350843	12/75 (16%)
Arid5b	XP_006514192.1	ARID_ARID5B	347..441	CDD:350649	31/93 (33%)
		PTZ00121	<437..>562	CDD:173412	23/127 (18%)