Protein Alignment: htk and ARID4A

• Sequence 1: NP_573330.3
• Gene: htk
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_016877049.1
• Gene: ARID4A
• HGNCID: 9885
• Length: 1284
• Species: Homo sapiens
• Alignment Length: 1430
• Identity: 360/1431 (25%)
• Similarity: 551/1431 (39%)
• Gaps: 417/1431 (29%)

  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:..|:|..|.|||:|||||:|||||||:..|.|.:||||..||...:.:|.||.:|.|   |||
Human     1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGP---LRV 62

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            ||:||.|..| ....||.|:|:.|.|.|||||||||..|||||:||||..|||.|||||||||||
Human    63 GAIVETRTSD-GSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLT 126

  Fly   131 HPEHFGNPVVGGR--RGRR------RGHLNEDSSEDDDESDAKEVVNEKEENIGKVVCVETESKK 187
            :|||||.||:..:  ||||      .....|:|||::||.  |..:|  :|.:||||.|.:.:
Human   127 NPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDED--KRRLN--DELLGKVVSVVSAT-- 185

  Fly   188 KDKEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEF------TREVASKQDV 246
             ::.:|:||||::|:....:.:: ||:.|||||.|.::|::.:|:..|.      ..|:::|
Human   186 -ERTEWYPALVISPSCNDDITVK-KDQCLVRSFIDSKFYSIARKDIKEVDILNLPESELSTK--- 245

  Fly   247 PAVQAALEFLDSSVLPAHWDRDSLFGLTNISSDDE-GEIDSDSSDDEPH---------------E 295
            |.:|.|..||.:.|:|.:|..|....|.:.||||| |..:.:..:.|..               |
Human   246 PGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEEEVPEEELDPE 310

  Fly   296 EKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFT 360
            |:|.|:.||||:|:|||||:||.|.:..:|::|::|||.|..:||.:.:.|...||.|.|.||..
Human   311 ERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQIYMDLGIP 375

  Fly   361 PCTVSVMNLVKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTE 425
            ....:....||.||:|:|..:.::.|...........:..:.|          ...|.:|....|
Human   376 ILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVK----------EEKKDLEESMEE 430

  Fly   426 TISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRK 490
            .: ||.|......|              .|.|...:.:.|:|..||        :.::.|:.:|:
Human   431 AL-KLDQEMPLTEV--------------KSEPEENIDSNSESEREE--------IELKSPRGRRR 472

  Fly   491 GSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSGG 555
            .:.      .|.|:.::.||:.|..:...:.|
Human   473 IAR------DVNSIKKEIEEEKTEDKLKDNDT--------------------------------- 498

  Fly   556 SATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEMQRSRDA 620
                    .|||.:.|...|                ||:.|                |:...|..
Human   499 --------ENKDVDDDYETA----------------EKKEN----------------ELLLGRKN 523

  Fly   621 SPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISVE-K 684
            :|                        |:::.:..||.|.:||.|:||:::...:..:.|...| :
Human   524 TP------------------------KQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGE 564

  Fly   685 IDTGDFVVGI-GDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRYDEWVPR 748
            .|..|....: |.|:||.|...|:.    ..|||.:....:..|..:|||||.|||.||||||..
Human   565 EDEEDMEPCLTGTKVKVKYGRGKTQ----KIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKA 625

  Fly   749 ERIAENLTKG---SKQKTRT--------------------------ISTSSAN-----SGSGGGG 779
            :||...|.||   .|||.:.                          .||.|:|     |.:....
Human   626 DRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSE 690

  Fly   780 GGGGGGGGGGGGGGGSLLVQGSQPPGVSDKQPG--------------KDGCSKMSPSSGNSTGPG 830
            |..|...........|.|..|.:....||.:..              ||...|....:.:.....
Human   691 GKSGTRSARSNIPDSSPLSNGMEDSCSSDSETEDALEKNLINEELSLKDELEKNENLNDDKLDEE 755

  Fly   831 APSLSGSL------------------------------GGASSTPSLLSTVVKTPPTGGAKRGRG 865
            .|.:|..:                              .....|..:.....|:|      :|:|
Human   756 NPKISAHILKENDRTQMQPLETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSP------KGKG 814

  Fly   866 RSDSMPPRSTTPS---SVVAHSGRTKSPAASQPQLQQQMKKRPTRVVPGTTTPRRVSDASMASES 927
            |      ||.|..   .::..|...::.|.|:|.::....:..:           :.:.:.:|.:
Human   815 R------RSKTKDLSLEIIKISSFGQNEAGSEPHIEAHSLELSS-----------LDNKNFSSAT 862

  Fly   928 DSDSDEPVRRPKRQSAKDKPQAGKAQPPGKGRLAS--SASSTAPAAHPSD-----------DSEE 979
            :.:.|:.|:..|.:    :...|::.|..|.|:.:  ..::|......||           ..:.
Human   863 EDEIDQCVKEKKLK----RKILGQSSPEKKIRIENGMEMTNTVSQERTSDCIGSEGMKNLNFEQH 923

  Fly   980 DEEEEEPSAARAASSKQQQQQASSLRGSRAGGNRAMSSGAASAKGRDYDLSEIRSELKGFQPKLL 1044
            .|.|.|...:..|.|.|..||.:|.|         ..|.|....  :..|.|....:....|:.|
Human   924 FERENEGMPSLIAESNQCIQQLTSER---------FDSPAEETV--NIPLKEDEDAMPLIGPETL 977

  Fly  1045 TNAASNEERKDLAKKEPSDEPALQDIKKE-----------PKL-------------------ESS 1079
            ..     ...||...:..|:.:::|:..|           |.|                   ||.
Human   978 VC-----HEVDLDDLDEKDKTSIEDVAVESSESNSLVSIPPALPPVVQHNFSVASPLTLSQDESR 1037

  Fly  1080 AKSSSTELSSETESYADEDSQSSDYRKQLKGSGAGKKEPTASPSKLHHEPVTKRELAVKEEPLKI 1144
            :..|.::::.|.:|.|:|..:....|:...|........|.|             :.|:|
Human  1038 SVKSESDITIEVDSIAEESQEGLCERESANGFETNVASGTCS-------------IIVQE----- 1084

  Fly  1145 EPKTEPKEEETKSKPFLSGADIKPTALIAPARFGNTSAAQAASSSGSSSTTAKYTSVIVEKPLTI 1209
                  :|...|.|.||..:..:|                   |.|:|...||
Human  1085 ------RESREKGKDFLGKSQKRP-------------------SDGNSGLMAK------------ 1112

  Fly  1210 GGKKSVEQHVPKK-AELLKKQSGGAGGTAASSSAASQESKKFAEPVASLKVEMP--AACSPSSSS 1271
                 .::..||: :...|.:..|.|.::.|......::.....||..|.|..|  .|.||:..|
Human  1113 -----KQKRTPKRTSAAAKNEKNGTGQSSDSEDLPVLDNSSKCTPVKHLNVSKPQKLARSPARIS 1172

  Fly  1272  1271
            Human  1173  1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	31/97 (32%)
		ARID	299..381	CDD:279697	35/82 (43%)
		Tudor-knot	692..751	CDD:288553	25/60 (42%)
ARID4A	XP_016877049.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C104880322
eggNOG	1	0.900				E1_KOG2744
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1970
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0001641
OrthoInspector	1	1.000				T610158
orthoMCL	1	0.900				OOG5_131238
Panther	1	1.100			LDO	PTHR13964
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1374
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	11	10.780