Protein Alignment htk and ARID4A

DIOPT Version :10

• Sequence 1: NP_573330.3
• Gene: htk / 32877
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_005268021.1
• Gene: ARID4A / 5926
• HGNCID: 9885
• Length: 1277
• Species: Homo sapiens
• Alignment Length: 1395
• Identity: 364/1395 - (26%)
• Similarity: 566/1395 - (40%)
• Gaps: 354/1395 - (25%)

  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:..|:|..|.|||:|||||:|||||||:..|.|.:||||..||...:.:|.||.:|.|   |||
Human     1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGP---LRV 62

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            ||:||.|..| ....||.|:|:.|.|.|||||||||..|||||:||||..|||.|||||||||||
Human    63 GAIVETRTSD-GSFQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLT 126

  Fly   131 HPEHFGNPVVGGR--RGRR------RGHLNEDSSEDDDESDAKEVVNEKEENIGKVVCVETESKK 187
            :|||||.||:..:  ||||      .....|:|||::||.  |..:|  :|.:||||.|.:.:
Human   127 NPEHFGTPVIAKKTNRGRRSSLPVTEDEKEEESSEEEDED--KRRLN--DELLGKVVSVVSAT-- 185

  Fly   188 KDKEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEF------TREVASKQDV 246
             ::.:|:||||::|:....:.:: ||:.|||||.|.::|::.:|:..|.      ..|:::|
Human   186 -ERTEWYPALVISPSCNDDITVK-KDQCLVRSFIDSKFYSIARKDIKEVDILNLPESELSTK--- 245

  Fly   247 PAVQAALEFLDSSVLPAHWDRDSLFGLTNISSDDE-GEIDSDSSDDEPH---------------E 295
            |.:|.|..||.:.|:|.:|..|....|.:.||||| |..:.:..:.|..               |
Human   246 PGLQKASIFLKTRVVPDNWKMDISEILESSSSDDEDGPAEENDEEKEKEAKKTEEEVPEEELDPE 310

  Fly   296 EKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFT 360
            |:|.|:.||||:|:|||||:||.|.:..:|::|::|||.|..:||.:.:.|...||.|.|.||..
Human   311 ERDNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCDNIDSGAVWKQIYMDLGIP 375

  Fly   361 PCTVSVMNLVKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTE 425
            ....:....||.||:|:|..:.::.|...........:..:.|          ...|.:|....|
Human   376 ILNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTVHHHEPKVK----------EEKKDLEESMEE 430

  Fly   426 TISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRK 490
            .: ||.|......|              .|.|...:.:.|:|..||        :.::.|:.:|:
Human   431 AL-KLDQEMPLTEV--------------KSEPEENIDSNSESEREE--------IELKSPRGRRR 472

  Fly   491 GSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSGG 555
            .:.      .|.|:.::.||:.|..:...:.|
Human   473 IAR------DVNSIKKEIEEEKTEDKLKDNDT--------------------------------- 498

  Fly   556 SATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEMQRSRDA 620
                    .|||.:.|...|                ||:.|                |:...|..
Human   499 --------ENKDVDDDYETA----------------EKKEN----------------ELLLGRKN 523

  Fly   621 SPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISVE-K 684
            :|                        |:::.:..||.|.:||.|:||:::...:..:.|...| :
Human   524 TP------------------------KQKEKKIKKQEDSDKDSDEEEEKSQEREETESKCDSEGE 564

  Fly   685 IDTGDFVVGI-GDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRYDEWVPR 748
            .|..|....: |.|:||.|...|:.    ..|||.:....:..|..:|||||.|||.||||||..
Human   565 EDEEDMEPCLTGTKVKVKYGRGKTQ----KIYEASIKSTEIDDGEVLYLVHYYGWNVRYDEWVKA 625

  Fly   749 ERIAENLTKG---SKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVSDKQ 810
            :||...|.||   .|||.:..:...:.......                            .::|
Human   626 DRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKRD----------------------------EERQ 662

  Fly   811 PGKDGCSKMSPSSGNSTGPGAPSLSGSLGGASSTPSLLSTVVKTPPTGGAKRGRGRSDSMPPRST 875
            ..|.|...:. |:.:|..|...|.:.:..|.|.|.|..|.:..:.|.     ..|..||....|.
Human   663 KSKRGRPPLK-STLSSNMPYGLSKTANSEGKSGTRSARSNIPDSSPL-----SNGMEDSCSSDSE 721

  Fly   876 TPSSVVAHSGRTKSPAASQPQLQQQMKKRPTRVVPGTTTPRRVSDASMASESDSDSDEPVRRPKR 940
            |..::      .|:....:..|:.:::|.................|.:..|:|....:|:...|.
Human   722 TEDAL------EKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPLETLKL 780

  Fly   941 QSAKD-----------------KPQAGKAQPPGKGR-------------LASSASSTAPA----- 970
            :..::                 |.:|.|: |.||||             ::|...:.|.:
Human   781 EVGENEQIVQIFGNKMEKTEEVKKEAEKS-PKGKGRRSKTKDLSLEIIKISSFGQNEAGSEPHIE 844

  Fly   971 AHPSDDSEED--------EEEEEPSAARAASSKQQQQQASSLRGSRAGGNRAMSS---------- 1017
            ||..:.|..|        |:|.:.........::...|:|..:..|......|::
Human   845 AHSLELSSLDNKNFSSATEDEIDQCVKEKKLKRKILGQSSPEKKIRIENGMEMTNTVSQERTSDC 909

  Fly  1018 -GAASAKGRDYDLSEIRSELKGFQPKLLTNAASNE-------ERKDLAKKEPSDEPALQD----- 1069
             |:...|..::: .....|.:| .|.|:  |.||:       ||.|...:|..:.|..:|
Human   910 IGSEGMKNLNFE-QHFERENEG-MPSLI--AESNQCIQQLTSERFDSPAEETVNIPLKEDEDAMP 970

  Fly  1070 -------IKKEPKLESSAKSSSTELSSETESYADEDSQSSDYRKQLKGSGAGKKEPTASPSKLHH 1127
                   :..|..|:...:...|.:    |..|.|.|:|:..          ...|.|.|
Human   971 LIGPETLVCHEVDLDDLDEKDKTSI----EDVAVESSESNSL----------VSIPPALP----- 1016

  Fly  1128 EPVTKRELAVKEEPLKIEPKTEPKEEETKSKPFLSGADIKPTALIAPARFGNTSAAQAASSSGSS 1192
             ||.:...:| ..||.:      .::|::|....|...|:..::...::.|   ..:..|::|..
Human  1017 -PVVQHNFSV-ASPLTL------SQDESRSVKSESDITIEVDSIAEESQEG---LCERESANGFE 1070

  Fly  1193 STTAKYT-SVIV-EKPLTIGGKK-----------SVEQHVPKK-AELLKKQSGGAGGTAASSSAA 1243
            :..|..| |:|| |:.....|:|           ..::..||: :...|.:..|.|.::.|....
Human  1071 TNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTGQSSDSEDLP 1135

  Fly  1244 SQESKKFAEPVASLKVEMP--AACSPSSSS 1271
            ..::.....||..|.|..|  .|.||:..|
Human  1136 VLDNSSKCTPVKHLNVSKPQKLARSPARIS 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	Tudor_ARID4_rpt1	10..60	CDD:410460	28/49 (57%)
		Tudor_ARID4_rpt2	65..118	CDD:410461	32/52 (62%)
		RBB1NT	170..263	CDD:462390	31/98 (32%)
		ARID	296..381	CDD:460187	37/84 (44%)
		CBD_RBP1_like	698..758	CDD:350843	25/59 (42%)
ARID4A	XP_005268021.1	Tudor_ARID4A_rpt1	4..61	CDD:410530	31/59 (53%)
		Tudor_ARID4_rpt2	62..114	CDD:410461	32/52 (62%)
		RBB1NT	170..262	CDD:462390	32/100 (32%)
		ARID_ARID4A	311..397	CDD:350646	37/85 (44%)
		CBD_RBP1_like	577..635	CDD:350843	26/61 (43%)