DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and arid3c

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	XP_005165415.1	Gene:	arid3c / 569444	ZFINID:	ZDB-GENE-060526-12	Length:	599	Species:	Danio rerio

Alignment Length:	526	Identity:	123/526 - (23%)
Similarity:	208/526 - (39%)	Gaps:	93/526 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 GNPVVGGRRGRRRGHLNEDSSEDDDESDAKEV---VNEKEENIGKVVCVETESKKKDKE------ 191
            |:|:      .||.  ..|..::|||.|..|:   ::::|.::.:...:......:|.|
Zfish   110 GHPL------ERRA--ESDIDDEDDEDDDPELDRGMDDEERDMDEDDSMNEGGGDEDLEGPLAHY 166

  Fly   192 ----KWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEAT--EFTREVASKQDVPAVQ 250
                ..:|....:|.:......||:..|......:......|:.::.  |:|.|...||......
Zfish   167 PPRHAVYPGAGQSPKSTPIHLSRVQPPYPAPRQAESPSALAPQAQSQHHEWTYEEQFKQSGQGSG 231

  Fly   251 AALEFLDSSVLPAHWDRDSLFGLTNISS--DDEGEIDSDSSDDEPHEEKDRFVAQLYKYMDDRGT 313
            ...:..||||         .||....||  .:..|:|.|       |::..|:..|:.:|..|||
Zfish   232 PGRKLKDSSV---------AFGGGGSSSLIQELYELDDD-------EKRKEFLDDLFSFMQKRGT 280

  Fly   314 PLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFL 378
            |:|::|.:..:.:|||.|::.|.::||...|.::..|:.|...|.......|....::..|.|:|
Zfish   281 PVNRIPIMAKQVLDLYTLYKLVTEKGGLVEVINKKIWREITKGLNLPTSITSAAFTLRTQYMKYL 345

  Fly   379 QPYGDFHRKLGC-SMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTETISKLAQPN-------- 434
            .||....|.|.. ..|..:.:|||.:||.....:::.:..|:.|.......||..|:
Zfish   346 YPYECEKRGLSSPGELQAAIDSNRREGRRQSYGSTLFNYSPVGTPTLLASPKLQMPHISMPTPNG 410

  Fly   435 ----QTNVVASTSSSAAAA---------SVAASSTPARAVSTASQSAA--EESGNTSESSVVVEP 484
                ||..:....|..::.         |:|...:.|:|.:.|:..||  |:.....||.   ||
Zfish   411 GHMTQTPGIKKEDSMLSSCLTNRVGIPMSLAGHHSAAQAAAAAAVQAAALEQLREKLESG---EP 472

  Fly   485 PKKQRKGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLS 549
            |:|            ||..:.|  |::.....|......|.:........:........||.|||
Zfish   473 PEK------------KVMLMAE--EQQRIMQHALQQNLFAMATQLPMNIKLNNRDDRQETALNLS 523

  Fly   550 SATSGGSATIATTAMNKDAESDLPLAKIKAAAVAAASTR----HSMEKETN---ISS--GSSASA 605
              |:|.|:...:..:|....:.:..|:..|.....:|.|    ||.:.::|   :||  ..|:||
Zfish   524 --TNGISSINMSIEINGVVYTGVLFARKPAIGFMPSSQRVHHQHSSQGKSNSPGLSSHIQPSSSA 586

  Fly   606 SSKANS 611
            ||.|:|
Zfish   587 SSSASS 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	18/102 (18%)
		ARID	299..381	CDD:279697	24/81 (30%)
		Tudor-knot	692..751	CDD:288553
arid3c	XP_005165415.1	BRIGHT	262..354	CDD:128777	27/91 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840