DRSC/TRiP Functional Genomics Resources

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Protein Alignment htk and Arid3b

DIOPT Version :10

Sequence 1:NP_573330.3 Gene:htk / 32877 FlyBaseID:FBgn0085451 Length:2486 Species:Drosophila melanogaster
Sequence 2:NP_062663.1 Gene:Arid3b / 56380 MGIID:1930768 Length:568 Species:Mus musculus


Alignment Length:615 Identity:132/615 - (21%)
Similarity:226/615 - (36%) Gaps:169/615 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 KSGRHFNESETL---------DQLPLTHPEHFGNPVVGG----------RRGRRRGHLNEDSSE- 157
            |.|....||:.|         ..|.:|.....|:.|:|.          .|...:.::|.:..| 
Mouse    28 KQGPQTRESQFLYASKLGTQPALLSITPGRPSGSSVLGPLARVPPATPVARMSEQSNVNSEPEEE 92

  Fly   158 ------DDDESDAKEVVNEKEENIGKVVCVETESKKKDK----EKWFPALVVAPTAQATVRIRVK 212
                  :|.:.|..||..::.:...|...::..::::.:    ....|...::|..|.|.....|
Mouse    93 EGGLEDEDGDDDVAEVAEKEAQAASKYFHMQKVTRQEPRATPMSSLLPVPGLSPQGQQTKEDHTK 157

  Fly   213 DEYLVRSFKDGRYYTVPKKEATEFTREVASKQDVPAVQAALEFLDSSVLPAHWDRDSLF---GLT 274
            |                           |||.. |:|..|.:       |: |..|...   |..
Mouse   158 D---------------------------ASKAP-PSVPTAGQ-------PS-WSLDEQLKQNGAL 186

  Fly   275 NISSDDEG----EIDSDSS-----DDEPHEEKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYR 330
            ..|.|.:|    ||..|.:     |.:|  |:..|:..|:.:|..||||:|::|.:..:.:|||.
Mouse   187 AWSDDADGGRGREISRDFAKLYELDGDP--ERKEFLDDLFIFMQKRGTPINRIPIMAKQILDLYM 249

  Fly   331 LFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFHRKLGC-SMLM 394
            |::.|.::||...:.::..|:.|...|.......|....::..|.|:|..|....:.|.. :.|.
Mouse   250 LYKLVTEKGGLVEIINKKIWREITKGLNLPTSITSAAFTLRTQYMKYLYAYECEKKALSSPAELQ 314

  Fly   395 TSRNSNRSKGRSLVRANSVASPKPMETMKTETISKLAQPNQTNVVASTSSSAAAASVAASSTPAR 459
            .:.:.||.:||....::|:....|...                ..|:.:::|||||.|::.|||.
Mouse   315 AAIDGNRREGRRPSYSSSLFGYSPAAA----------------AAAAAAAAAAAASAASAGTPAL 363

  Fly   460 AVSTA---SQSAAEESGNTSESSVVVEPPKKQRKGSA-------------------ASSQQGKVK 502
            ..|..   |......|..||.||..:.|....|||..                   |.::.|.::
Mouse   364 LSSPKIRFSILGLGSSSGTSASSPRIPPASTLRKGDGVPVPVPNRLAVSGTLAGQQAGNRPGPLE 428

  Fly   503 SLVEKY------EEKSTAVQATSSGTVAGS---GASASAAAMP---------TTSAAASTATNLS 549
            .|.|:.      |:|::.:.......|..:   ...:.|..:|         ..:..::.|.||:
Mouse   429 HLRERLESGEPPEKKASRLSEEEQRLVQQAFQRNLFSMARQLPMKIRINGREDRAEPSAPALNLT 493

  Fly   550 SATSGGSATIATTAMNKDAESD------LPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSK 608
            ::..|        ::|...:.|      :..|:.....:.|.||..|:        |||||:|:.
Mouse   494 TSNIG--------SINMSVDIDGTTYTGVLFAQKPVVHLIAGSTPQSI--------GSSASSSNS 542

  Fly   609 ANSAEMQRSRDASPSVAA---PPSAGASTS 635
            ::|       ..|||..:   .|||..|||
Mouse   543 SSS-------HCSPSPTSSRGTPSAEPSTS 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htkNP_573330.3 Tudor_ARID4_rpt1 10..60 CDD:410460
Tudor_ARID4_rpt2 65..118 CDD:410461 2/4 (50%)
RBB1NT 170..263 CDD:462390 13/96 (14%)
ARID 296..381 CDD:460187 24/84 (29%)
CBD_RBP1_like 698..758 CDD:350843
Arid3bNP_062663.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..174 31/181 (17%)
Interaction with RB1. /evidence=ECO:0000250 201..374 48/190 (25%)
ARID_ARID3B 202..327 CDD:350643 34/126 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 378..403 9/24 (38%)
Interaction with ARID3A. /evidence=ECO:0000250 495..518 3/30 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..568 18/52 (35%)
Blue background indicates that the domain is not in the aligned region.

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