Protein Alignment htk and Arid4a

DIOPT Version :10

• Sequence 1: NP_573330.3
• Gene: htk / 32877
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_038968184.1
• Gene: Arid4a / 314205
• RGDID: 1307442
• Length: 1277
• Species: Rattus norvegicus
• Alignment Length: 1508
• Identity: 381/1508 - (25%)
• Similarity: 576/1508 - (38%)
• Gaps: 425/1508 - (28%)

  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:..|:|..|.|||:|||||:|||||||:..|.|.:||||..||...:.:|.||.:|.|   |||
  Rat    20 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGP---LRV 81

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            ||:||.|..| ..:.||.|:|:.|.|.|||||||||..|||||:||||..|||.|||||||||||
  Rat    82 GAIVETRTSD-GSIQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLT 145

  Fly   131 HPEHFGNPVVGGR--RGRRRG-HLNEDSSEDD---DESDAKEVVNEKEENIGKVVCVETESKKKD 189
            :|||||.||:..:  ||||.. .:.||..|::   :|.:.|..:|  :|.:|:||.|   |....
  Rat   146 NPEHFGTPVIAKKTNRGRRSSLPITEDEKEEESSGEEEEDKRRLN--DEFLGRVVNV---SPTAQ 205

  Fly   190 KEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEF------TREVASKQDVPA 248
            ..:.:|||||:|:....|.:: ||:.|||||.|.::|:|.:|:..|.      ..|:.:|   |.
  Rat   206 STECYPALVVSPSCNDDVTVK-KDQCLVRSFIDSKFYSVARKDIKELDLLSLPESELCTK---PG 266

  Fly   249 VQAALEFLDSSVLPAHWDRDSLFGLTNISSDDEGEIDSDSSDDEPH-----------------EE 296
            ::.|..||.:.::|.:|..|....|.:.||||| |..::..::|..                 ||
  Rat   267 LRRASVFLKARIVPDNWKMDISEILESSSSDDE-ECPAEEHEEEKEKEAKKEEEELPEEELDPEE 330

  Fly   297 KDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTP 361
            :|.|:.||||:|:|||||:||.|.:..:|::|::|||.|..:||.:.:.|...||.|.|.||...
  Rat   331 RDNFLQQLYKFMEDRGTPINKAPVLGYKDLNLFKLFRLVYHQGGCDSIDSGAVWKQIYMDLGIPI 395

  Fly   362 CTVSVMNLVKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSK------GRSLVRANSVASPKPME 420
            ...:....||.||:|:|..:.::.|...........:..:.|      ..|:..|..||...|:.
  Rat   396 LNSAASYNVKTAYRKYLYGFEEYCRSANIQFRTIHHHEPKVKEEKKDFEESMDEALKVAQEMPLM 460

  Fly   421 TMKTETISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPP 485
            .:|:|                               |...:.:.|:|..|::        .::.|
  Rat   461 DVKSE-------------------------------PEENIDSNSESDREDT--------ELKSP 486

  Fly   486 KKQRKGSAASSQQGKVKSLV--EKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNL 548
            :.:||   ...:...:|..:  ||.|:|
  Rat   487 RGRRK---IVREANCIKKELEEEKIEDK------------------------------------- 511

  Fly   549 SSATSGGSATIATTAMNKDA-ESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSA 612
                     .|.....|||| :.|..:|:               :|||.:..|...:...|
  Rat   512 ---------LIGDDIDNKDADDDDYDIAE---------------KKETELLLGRKTTPKHK---- 548

  Fly   613 EMQRSRDASPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKK 677
                                             .||.|.|...:.|.|::::|.:::..:..|..
  Rat   549 ---------------------------------EKKIKQQEDSERDSEEEEEKSQEREETESRCD 580

  Fly   678 EKISVEKIDTGDFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRY 742
            .:...::.||...:.  |.|:||.|...|:.    ..|||.:....:..|..:|||||.|||.||
  Rat   581 SEGEDDEDDTEPCLT--GTKVKVKYGRGKTQ----KIYEASIKSTEMDDGEVLYLVHYYGWNVRY 639

  Fly   743 DEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVS 807
            ||||..:||...|.||..:|.:.....:...                                 |
  Rat   640 DEWVKADRIIWPLDKGGPKKKQKKKVKNKED---------------------------------S 671

  Fly   808 DKQPGKDGCSKMSPSSGNSTGPGAPSLSGSLGGASSTPSLLSTVVKTPPTGGAKRGRGRSDSMPP 872
            :|...:|       .....:..|.|.|..:.  :|:.|..||   ||      ....|:|||
  Rat   672 EKDEKRD-------EERQKSKRGRPPLKSTF--SSNMPYSLS---KT------SNSEGKSDS--- 715

  Fly   873 RSTTPSSVVAHSGRTKSPAASQ--PQLQQQMKKRPTRVVPGTTTPRRVSDASMASESDSDSDEPV 935
               ..|...|.....||..:.:  |.::::::|           ...|.|..:|.|:
  Rat   716 ---CSSDSEAEDQLEKSSVSEELSPDIKEELEK-----------SENVHDDKLAEEN-------- 758

  Fly   936 RRPKR---QSAKDKPQAGKAQPPGKGRLASSASSTAPAAHPSDDSEEDEEEEEPSAARAASSKQQ 997
              ||.   .:..|:.||..::|     |...|..:....|...|..|..||          .|:|
  Rat   759 --PKTVHISNENDRTQAQPSEP-----LTVEAGDSDQIVHIFGDKVEQAEE----------LKKQ 806

  Fly   998 QQQASSLRGSRAGGNRAMSSGAASAKGRDYDLSEIRSELKG------FQPKLLTNAASNEERKDL 1056
            .:::...:|.|   |:.........|...:...|..||.:|      |......|.:|.|:..|.
  Rat   807 VEKSPKAKGRR---NKTKDLSLELIKISPFSQEEAGSEARGDTHSLEFSSLECKNFSSTEDDVDQ 868

  Fly  1057 AKKEPSDEPAL---QDIKKEPKLESSAKSSSTELSSE--TESYADEDSQSSDYRKQLKGSGAGKK 1116
            .:||...:..:   ...:|:.:||:..: .:|.||.|  .:|...|..:.....::.:..|.|..
  Rat   869 YEKEKKLKRKILGQHSPEKKLRLENGVE-MTTGLSQERSDDSAVAEGVKGVHVEQRFEAEGEGMP 932

  Fly  1117 EPTASPSKLHHEPVTKRELAVKEEPLKIEPKTEPKEEE----------------------TKSKP 1159
            ...|.|.:...||...:..:..|||    ..|..||||                      .|.||
  Rat   933 SLIAEPDQGIQEPTGVKPDSPAEEP----AHTPLKEEEDVMPLIGPETLVCHEVDLDDLDEKEKP 993

  Fly  1160 FLSGADIK----------PTALIAPARFGNTSAAQAASSSGSSSTTAKYTSVIV----------- 1203
            .:....|:          |.|| .|....|.|.|...:.|...|.:.|..|.|.
  Rat   994 SIEDVVIEGSESNSLGSVPPAL-PPVAQQNFSVASPLTLSQDESRSIKSESDITIEVDSIAEESQ 1057

  Fly  1204 ------------EKPLTIG--------------GKK-----------SVEQHVPKK-AELLKKQS 1230
                        |..:|.|              |:|           ..::..||: :...|.:.
  Rat  1058 EGLCERESANGFEASVTSGACGMIVHERESREKGQKRPSDANSGLMAKKQKRTPKRTSAAAKSEK 1122

  Fly  1231 GGAGGTAASSSAASQESKKFAEPVASLKV-------EMPAACSP----------------SSSSS 1272
            .|||.::.|....:.:|.....||..|.:       ..||..||                ||..:
  Rat  1123 NGAGQSSDSEDLPAMDSSSNCTPVKRLSLPKPQKLPRSPARISPHIKDGEKEKHREKHPNSSPRT 1187

  Fly  1273 SSSSF-----CSTGSAVSSSSATRSLPDMSKLEISSGTVPGATPGAAALQPSNVAQVSSSGAAKE 1332
            ...||     .:..|....|.....|.::.|..:|..:.................:||.:||:..
  Rat  1188 YKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREVSHAGASMS 1252

  Fly  1333 SKYSSSGGAAAGS 1345
            |..|.:|.:.:.|
  Rat  1253 SASSDTGMSPSSS 1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	Tudor_ARID4_rpt1	10..60	CDD:410460	28/49 (57%)
		Tudor_ARID4_rpt2	65..118	CDD:410461	32/52 (62%)
		RBB1NT	170..263	CDD:462390	31/98 (32%)
		ARID	296..381	CDD:460187	37/84 (44%)
		CBD_RBP1_like	698..758	CDD:350843	25/59 (42%)
Arid4a	XP_038968184.1	Tudor_ARID4A_rpt1	23..80	CDD:410530	31/59 (53%)
		Tudor_SF	81..137	CDD:470623	35/56 (63%)
		RBB1NT	189..281	CDD:462390	32/100 (32%)
		ARID	331..416	CDD:355778	36/84 (43%)
		CBD_RBP1_like	597..655	CDD:350843	26/61 (43%)