Protein Alignment htk and RGD1564748

DIOPT Version :9

• Sequence 1: NP_573330.3
• Gene: htk / 32877
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_008771270.1
• Gene: RGD1564748 / 302311
• RGDID: 1564748
• Length: 2298
• Species: Rattus norvegicus
• Alignment Length: 2384
• Identity: 480/2384 - (20%)
• Similarity: 757/2384 - (31%)
• Gaps: 693/2384 - (29%)

  Fly   106 RRTALCLKSGRHFNESETLDQLPLTHPEHFGNPVVGGRRGRRRGHLNEDSSEDDDESDAKEVVNE 170
            |.|.....:|||.:||....: .|..||. .|.........:...|.:|..||......|....|
  Rat   151 RMTQKSASAGRHHSESHRSGK-TLRFPEK-SNIKENHHSSVKHSSLEKDHPEDRGRPIKKRCPTE 213

  Fly   171 KEENIGKVVCVETESKKKDKEKWFPALVVAPTAQATV---RIRVKDEYLVRSFKDG-RYYTVPKK 231
            |.::..|....|..|.....|:..|.....||.:...   |...|..|..::.... |.:.:.:.
  Rat   214 KSQSTEKGQLTERSSYAPATERGRPTKRSQPTKKGLSNENRHPAKKGYSAKTPGSAERDHQIERG 278

  Fly   232 EATE----FTREVASKQDVPAVQAALE--------FLDSSVLPAHWDRDSLFG-----LTNISSD 279
            .||:    ..::..|::..||.::.||        ..:|.|:.|  ::|.|.|     .:|.|.:
  Rat   279 GATDSGLSTEKDCPSRRRRPAKKSHLEEKVHSQKSSYESRVISA--EKDGLAGRVRRKRSNPSEE 341

  Fly   280 DEGEIDSDSSDDEPHEEKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRV 344
            ......|......|...|||.|    :...|:..|        ..|      .|:|:.....:|.
  Rat   342 GHSVKCSICDSSVPSAGKDRPV----RSRSDKSNP--------GED------RRSVESGISASRG 388

  Fly   345 TSQNQWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRS--- 406
            .|..:         .:|......|.:::|.|.....||      ..:....|...:|..||.
  Rat   389 PSAGK---------DSPAGRGRPNKIRRAEKGHSMEYG------SSAPRGPSAGKDRPGGRGHPN 438

  Fly   407 ---------LVRANSVASPKPMETMKTETI-------SKLAQ----------------------- 432
                     .|.:::.||..|..|.|...:       :.||:
  Rat   439 KSGPTEESRSVESDTCASKGPSTTGKERPVRRCRLNKNSLAERLCSIQCGICTPRGPSAGKHCSE 503

  Fly   433 ----PNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRKGSA 493
                ||: .|.|....|  ..:::||..|:......::|.:.:||.|.|...|        :||.
  Rat   504 RRGRPNK-RVPAEEDRS--LKNISASRRPSGGKDRPARSRSNKSGPTKEGWSV--------EGSR 557

  Fly   494 ASS---QQGK---------VKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTAT 546
            ::|   .:||         .||..||........::||.|..||...||..:   :::.:..|..
  Rat   558 STSGRPSEGKDRSGGRGRPNKSGPEKEGPSVNDSRSTSRGPSAGKDRSARRS---SSNKSGPTEE 619

  Fly   547 NLS---------SATSGGSATIATTAMNKDAESDLPLAKIKA--AAVAAASTR--HSME----KE 594
            :||         ..::|.........:||::.:: ....||.  .|:...|||  ||.|    ||
  Rat   620 SLSDERDICESRGPSTGKERPARKCRLNKNSLAE-QWCSIKCGICALKQFSTRKDHSRERGRSKE 683

  Fly   595 TNISSGS-------------------------------------------------------SAS 604
            :.:..||                                                       :.|
  Rat   684 SGVEVGSHLVKSGVSTPRGPSAGKDLPAGRGRPNKSSPAEEGCSVKSSISASRRPSVGRDRPARS 748

  Fly   605 ASSKANSAEMQRSRDASPSVAAPPSAGASTSGAAATAQTASNKKE----KHQRSKQADKEKDKDK 665
            .|:|:.|||...|..........||||....|........|.|||    |..||........||:
  Rat   749 CSNKSGSAEESCSVKCGICTPKVPSAGKDRPGGRGCPNKNSPKKEDPSVKGGRSTSRGPSAGKDR 813

  Fly   666 EEKQASSGKR--KKEKISVEKIDTGDFVVGIG-----DKLKVNYHEKKSPSSHGSTYEAKVIE-- 721
            ...:..:.|.  .:|..|||    |......|     |:.....|..||    |...|::.:|
  Rat   814 SGGRGHTNKSGPAEESRSVE----GSRSTSRGPSAGKDRSGRRRHTNKS----GPAEESRSVEGI 870

  Fly   722 ISVQRGVPMYLVHYTGWNNRYDEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGG 786
            .|..||.       :...:|     |..|...|.:...|:......:.|.:.|...|....||.|
  Rat   871 RSTSRGP-------SAGKDR-----PGRRGYPNKSSPKKEGPSVKGSRSTSRGPSAGKDRSGGRG 923

  Fly   787 --GGGGGGGGSLLVQGSQP----PGVSDKQPGKDGC-SKMSP-------------SSGNSTGPGA 831
              ...|....|..|:||:.    |.....:||:.|. :|.||             |.|.|||...
  Rat   924 HTNKSGSAEESHSVEGSRSTSRGPSAGKDRPGRRGYPNKSSPKKEGPSVKGSRSTSRGPSTGKDR 988

  Fly   832 PSLSG------------SLGGASSTPSLLSTVVKTPPTGGAKR--GRGRSDSMPPRSTTPSSVVA 882
            |...|            |:.|:.||        ...|:.|..|  |||..:...|:...| ||..
  Rat   989 PGRRGYPNKNSPKKEGPSVKGSRST--------SRGPSAGKDRPGGRGYPNKSSPKKEGP-SVKG 1044

  Fly   883 HSGRTKSPAASQPQLQQQMKKRP-TRVVPGTTTPRRVSDASMASESDS-----DSDEPVRR---- 937
            ....::.|:|.        |.|| .|..|..::|::...:...|.|.|     ..|.|.||
  Rat  1045 SRSTSRGPSAG--------KDRPGRRGYPNKSSPKKEGPSVKGSRSTSRGPSAGKDRPGRRGYPN 1101

  Fly   938 ---PKRQSAKDK--------PQAGKAQPPGKGRLASSASSTAPAAHPSDDSEEDEEEEE----PS 987
               ||::....|        ..|||.:|.|:||  |:.||      |:::|...|....    ||
  Rat  1102 KNIPKKEGPSVKCSRNTSRGSSAGKDRPGGRGR--SNKSS------PTEESRSVEGSRSTSRGPS 1158

  Fly   988 AARAASSKQQQQQASSLR--GSRAGGNRAMSSGAASAK---GRDYDLSEIRSELKGFQPK----L 1043
            |.:....::.....||.:  ||...|:|:.|.|.::.|   ||       ||......||    .
  Rat  1159 AGKDRPGRRGYPNKSSPKKEGSSVKGSRSTSRGPSAGKDRPGR-------RSYPNKSSPKKEGPS 1216

  Fly  1044 LTNAASNEERKDLAKKEPSDEPALQDI---KKEPKLESSAKSS---------------STELSSE 1090
            :..:.|........|..|.....|.:.   ||.|.::.|..:|               |.:.|..
  Rat  1217 VKGSRSTSRGPSAGKDRPGGRSHLNECGPEKKCPSVKDSRSTSRGPSAGKDRPGRRGRSNKSSPT 1281

  Fly  1091 TESYADEDSQSSDYRKQLKGSGAGKKEP-------TASPSKLHHEPVTKRELAVKEEPLKIEPKT 1148
            .||.:.|.|:|:.     :|..|||..|       .:||.|  ..|..|...:....|...:...
  Rat  1282 EESRSVEGSRSTS-----RGPSAGKDRPGRRGYPNKSSPKK--EGPSVKGSRSTSRGPSAGKDHP 1339

  Fly  1149 EPKEEETKSKPFLSGADIK--------PTA-LIAPARFG---NTSAAQAASSSGSSSTTAKYTSV 1201
            ..:....||.|...|..:|        |:| ...|.|.|   .:|..:...|...|.:|::..|.
  Rat  1340 GRRSYPNKSSPKKEGPSVKGSRSTSRGPSAGKDRPGRRGYPNKSSPKKEGPSVKGSRSTSRGPSA 1404

  Fly  1202 IVEKPLTIGGKKSVEQHVPKKAELLKKQSGGAGGTAASSSAASQESKKFAEPVASLKVEMPAA-- 1264
            ..::|    |::.    .|.|.  :.|:.|.:...:.|:|..|...|           :.|..
  Rat  1405 GKDRP----GRRG----YPNKN--ISKKEGPSVKCSRSTSRGSSAGK-----------DRPGGRG 1448

  Fly  1265 ----CSPSSSSSSSSSFCST--GSAVSSS-SATRSLPDMS-------KLEISSGTVPGATPGAAA 1315
                .||:..|.|.....||  |.:|... ...|..|:.:       .::.|..|..|::.|..
  Rat  1449 RSNKSSPTEESRSVEGIRSTSRGPSVGKDRPGRRGYPNKNIPKKEGPSVKCSRSTSRGSSAGKD- 1512

  Fly  1316 LQPSNVAQVSSSGAAKESK-----YSSSGGAAAGSGISMRKLLSSDVYEFKDTEPFEFEKRISPM 1375
             :|....:.|.|...:||:     .|:|.|.:.|...|.::...|.....::...|:..:..|..
  Rat  1513 -RPGGRGRSSKSSPTEESRSVEGIRSTSRGPSVGKDHSGKRGHPSKRGPEEEGPSFKGSRSTSRR 1576

  Fly  1376 ASVG-------------GTVAAAATAAGAMAAAGAASVITTMVPTPGASGSGVAASASTSAPVVV 1427
            .|||             |......:..|.::.:..:||        |...||.....:...|...
  Rat  1577 PSVGKDRSGGRGHSNKSGPEKGDPSVKGRLSISRGSSV--------GKDHSGGRGHPNERGPEKE 1633

  Fly  1428 GSAARKQALKASAIQHILEHQSPAAGRER-GGYGGMTSSISLLTAPKLKKRGSPLKEAALCME-- 1489
            |.:|:.....:         :.|:.|::| ||.|....|......|.:|...|..:.:::..:
  Rat  1634 GPSAKGSRSTS---------RGPSVGKDRSGGRGHSNKSGPEKEGPSVKGSRSTSRGSSVGKDRR 1689

  Fly  1490 --KAKTYKLDKDQVQQPVEQKTQQLIQPTLGPVESYGAGSPEAMSNLSTPTTSSGHAQLSASSTY 1552
              :..:.|...::....|:........|:||.....|.|.|    |.|.|.......:.|..::
  Rat  1690 GGRGHSNKSGPEREDPSVKGSHNTSRGPSLGKDRPGGRGHP----NKSGPAEKIRSVESSTCAS- 1749

  Fly  1553 SQLTPHHATPFDALRKSPSFNLNITALNEELAQTVQETTRALTDALQPPSTPVPPTVSASGSTPT 1617
                           |.||      |.||..|:.......:|.:..
  Rat  1750 ---------------KEPS------AGNERPARRYHSNKSSLAEGC------------------- 1774

  Fly  1618 AVTPVITAMPTAGTAGLSCPSTPPTG--------ANPVLASPKLSTPPQAINASKQPPASHIVGS 1674
                      .:..:|:..|..|..|        .|...::.|..:...:.|.|:.|.|..
  Rat  1775 ----------CSIKSGICVPRGPSAGNDHCGRGRPNKSGSAKKSHSVEHSSNISRGPSAGK---- 1825

  Fly  1675 PFIETRNVFELSTSNEGSGYSSGESKDNKF-------EKLENVKILLAGAVGPFDLDAGSYEQKT 1732
                     :.|||.      ||.||.|:.       ||....|      .||.........::.
  Rat  1826 ---------DRSTSR------SGPSKKNQLAQEGPSKEKESYAK------RGPSKRKEHHAGRRP 1869

  Fly  1733 SSIADKVLKAISQKKEEVEN-NKGKPPVEPAAAAKTPGREDVVPSPTAKLDLCSSAIKLDTLKLL 1796
            :|         ||.:||..: .:||....|:|....|..:...|..
  Rat  1870 NS---------SQHEEEFRSFGRGKSKRGPSAGKDHPTGKGQPPKK------------------- 1906

  Fly  1797 SEPLKIQTGPLLGELYRPGPATSSPETKSILESSLPAKNSELSETIQKLECAIQQRKTPVG---- 1857
            |.|.|..:....|.....|.:|.....   .:...|.|.|...|....:|...::||...|
  Rat  1907 SRPEKDSSSAERGNHAERGQSTGKDHP---TDRGQPRKKSHPEEVGHSVEKGNEERKPSAGKDPH 1968

  Fly  1858 ---GALS---------LASSTAGTPPTAHTPNSTATAGAGFSDESMDSTD--------------- 1895
               |..|         |::|....||..|.|..........|.|.:.|.:
  Rat  1969 TKRGRPSKKSHPAERHLSASMKYCPPKKHRPAENVCVKRVRSPERVHSMERGHIAKRSCLAERQL 2033

  Fly  1896 -------SEQRLVIEDVIAEEHTTTTTTGE-------------------QKSPGSQQEEGQTNT- 1933
                   :|:...:|..::||.....|..:                   :.|.||.....:.|.
  Rat  2034 SAEEGSMAEEGCSVETDLSEERAEEGTVVDNMCSVENGHPSMEKVFLEVKPSSGSMSRVTEPNNL 2098

  Fly  1934 -ATMATAVTAETEGTSSSTPTPPVPAPVKLELGAKAMPGIQAPIPLK------------------ 1979
             :|....:.::|... :..|...:|..||:::|.:    ::.|..||
  Rat  2099 QSTPEKRIDSDTNQV-AQVPHCNLPVTVKIKMGVE----LRVPDELKSRLVEDWDLINKQKQLFQ 2158

  Fly  1980 -PAEGS--SFAGKLTGVVQPPPLAKLQQ----------QEELGQAQGQSKSISSFGIP------I 2025
             |||.:  :...:....|:...||..::          :|...:..| ::.:..|..|      :
  Rat  2159 LPAEKNVDTILAEYVTFVKSQGLADNREYSVDEVVAGIREYFNRMLG-TQLLCQFEKPQYAEIHL 2222

  Fly  2026 VLPEIPASVVVATPAL--MVASAATVMRHSPGSTPNSQAPVLIS 2067
            ..|:||.|.|...|.|  :.....|.:.:||   .|.|:.:|:|
  Rat  2223 AYPDIPMSQVYGAPHLLRLFVKIGTALANSP---LNRQSLLLVS 2263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	21/106 (20%)
		ARID	299..381	CDD:279697	13/81 (16%)
		Tudor-knot	692..751	CDD:288553	13/65 (20%)
RGD1564748	XP_008771270.1	MRG	2124..2281	CDD:283390	30/148 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1624495at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010