Protein Alignment: htk and Arid4a

• Sequence 1: NP_573330.3
• Gene: htk
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: NP_001074664.1
• Gene: Arid4a
• MGIID: 2444354
• Length: 1261
• Species: Mus musculus
• Alignment Length: 1648
• Identity: 402/1649 (24%)
• Similarity: 603/1649 (37%)
• Gaps: 483/1649 (29%)

  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:..|:|..|.|||:|||||:|||||||:..|.|.:||||..||...:.:|.||.:|.|   |||
Mouse     1 MKAADEPAYLTVGTDVSAKYRGAFCEAKIKTVKRLVKVKVLLKQDNTTQLVQDDQVKGP---LRV 62

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            ||:||.|..| ..:.||.|:|:.|.|.|||||||||..|||||:||||..|||.|||||||||||
Mouse    63 GAIVETRTSD-GSIQEAIISKLTDASWYTVVFDDGDERTLRRTSLCLKGERHFAESETLDQLPLT 126

  Fly   131 HPEHFGNPVVGGR--RGRR------RGHLNEDSSEDDDESDAKEVVNEKEENIGKVVCVETESKK 187
            :|||||.||:..:  ||||      .....|:|||::||.  |..:|  :|.:||||.|.:.:
Mouse   127 NPEHFGTPVIAKKTNRGRRSSLPITEDEKEEESSEEEDED--KRRLN--DELLGKVVSVASTA-- 185

  Fly   188 KDKEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDV---PAV 249
             :...|:|||||:|:....|.:: ||:.|||||.|.::|::.:|:..|.......:.::   |.:
Mouse   186 -ESTGWYPALVVSPSCNDDVTVK-KDQCLVRSFIDSKFYSIARKDIKELDILTLPESELCARPGL 248

  Fly   250 QAALEFLDSSVLPAHWDRDSLFGLTNISSDDEGEIDSDSSDDEPH-----------------EEK 297
            :.|..||...::|.:|..|....|.:.||||| |..::..::|..                 ||:
Mouse   249 RRASVFLKGRIVPDNWKMDISEILESSSSDDE-ECPAEEHEEEKEKEAKKEEEELPEEELDPEER 312

  Fly   298 DRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFTPC 362
            |.|:.||||:|:|||||:||.|.:..:|::|::|||.|..:||...:.|...||.|.|.||....
Mouse   313 DNFLQQLYKFMEDRGTPINKPPVLGYKDLNLFKLFRLVYHQGGCGNIDSGAVWKQIYMDLGIPIL 377

  Fly   363 TVSVMNLVKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPMETMKTETI 427
            ..:....||.||:|:|..:.::.|......                |......||..|..|
Mouse   378 NSAASYNVKTAYRKYLYGFEEYCRSANIQF----------------RTIHHHEPKVKEEKK---- 422

  Fly   428 SKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPPKKQRKGS 492
                         ....|...|...|...|...|.:..:...:.:..:......::.|:.:||
Mouse   423 -------------DFEDSMDEALKEAPEMPLLDVKSEPEENTDSNSESDREDTELKSPRGRRK-- 472

  Fly   493 AASSQQGKVKSLV--EKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSSATSGG 555
             .......:|..:  ||.|:|
Mouse   473 -IVRDANCIKKEIEEEKIEDK-------------------------------------------- 492

  Fly   556 SATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEMQRSRDA 620
              .:.....||||..|      ......||...|                       |:...|.:
Mouse   493 --FLRDDLENKDAGDD------DDDGDPAAKREH-----------------------ELLFGRKS 526

  Fly   621 SPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASSGKRKKEKISVEKI 685
            :|                      .||::|.:  |..|.|:|.|:||:::...:..:.:...|..
Mouse   527 TP----------------------KNKEKKIK--KPEDSERDSDEEEEKSQEREETESRCDSEGE 567

  Fly   686 DTGDFVVG--IGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTGWNNRYDEWVPR 748
            |..|....  .|.|:||.|...|:.    ..|||.:....:..|..:|||||.|||.||||||..
Mouse   568 DEEDDTEPCLTGTKVKVKYGRGKTQ----KIYEASIKSTEMDDGEILYLVHYYGWNVRYDEWVKA 628

  Fly   749 ERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVSDKQPGK 813
            :||...|.||..:|.:.....:...                                 |:|...:
Mouse   629 DRIIWPLDKGGPKKKQKKKVKNKED---------------------------------SEKDEKR 660

  Fly   814 DGCSKMSPSSGNSTGPGAPSLSGSLGGASSTPSLLSTVVKTPPTGGAKRGRGRSDSMPPRSTTPS 878
            |       .....:..|.|.|..:.     :|::..::.||      ....|:|||....|....
Mouse   661 D-------EERQKSKRGRPPLKSTF-----SPNMPYSLSKT------SNSEGKSDSCSSDSEADD 707

  Fly   879 SVVAHSGRTKSPAASQPQLQQQMKKRPTRVVPGTTTPRRVSDASMASESDSDSDEPVRRPKRQSA 943
            .:...||...    ..|.::::::|                     :|:..|.......||....
Mouse   708 QLEKSSGGED----LSPDVKEELEK---------------------NENAHDDKLDEENPKIVHI 747

  Fly   944 KDKPQAGKAQPPGKGRLASSASSTAPAAHPSDDSEEDEEE-----EEPSAARAASSKQQQQQASS 1003
            ..:....:|||  ...|...|..:....|...|..:..||     |:....:...||.:......
Mouse   748 SKENDRTQAQP--SDTLTVEAGDSDQIVHIFGDKVDQVEEFKKQVEKSPKGKGRRSKTKDLSLEL 810

  Fly  1004 LRGSRAGGNRAMSSGAASAKGRDYDLSEIRSELKGFQPKLLTNAASNEERKDLAKKEPSDEPAL- 1067
            ::.|..|...|    .:.|.|..:.|.....|.|.|        :|.|:..|..:||...:..:
Mouse   811 IKISPFGQEEA----GSEAHGDVHSLEFSSLECKNF--------SSTEDDIDPYEKEKKLKRKIL 863

  Fly  1068 --QDIKKEPKLESSAKSSSTELSSE--TESYADEDSQSSDYRKQLKGSGAGKKEPTASPSKLHHE 1128
              |..:|:.:|::..: .:|.:|.|  .:....|..:.:...:..:..|.|....||.|.:...|
Mouse   864 GQQSPEKKLRLDNGME-MTTGVSQERSDDGAGAEGMKGAHVEQHFETEGEGMPSLTAEPDQGLQE 927

  Fly  1129 PVTKRELAVKEEPLKIEPKTEPKEEETKSKPFLSGADIKPTALIAPARFGNTSAAQAASSSGSSS 1193
            ..:::    .:.|.:.||...|.:||..:.|           ||.|.
Mouse   928 LTSEK----SDSPAEEEPVHTPLKEEEDAMP-----------LIGPE------------------ 959

  Fly  1194 TTAKYTSVIVE---KPLTIGGKKSVEQHVPKKAELLKKQSGGAGGTAASSSAASQESKKFAEPVA 1255
                 |.|..|   ..|....|.|:|..|.:.:|              |:|.||
Mouse   960 -----TLVCHEVDLDDLDEKDKTSIEDVVVEGSE--------------SNSLAS----------- 994

  Fly  1256 SLKVEMPAACSPSSSSSSSSSFCSTGSAVSSSSATRSLPDMSKLEISSGTVPGATPGAAALQPSN 1320
                 :|.|..|    .:..:|........|...:||:...|.:.|               :..:
Mouse   995 -----VPPALPP----VAQHNFSVASPLTLSQDESRSIKSESDITI---------------EVDS 1035

  Fly  1321 VAQVSSSGAAKESKYSSSGGAAAGSGISMRKLLSSDVYEFKDTEPFEFEKRISPMASVGGTVAAA 1385
            :|:.|..|..:  :.|::|                            ||
Mouse  1036 IAEESQEGLCE--RESANG----------------------------FE---------------- 1054

  Fly  1386 ATAAGAMAAAGAASVITTMVPT-------PGASGSGVAASASTSAPVVVGSAARKQALKASAIQH 1443
                 |..|:||.|:|.....:       |....||:.|......|....:||:.:  |..|.|.
Mouse  1055 -----ASVASGACSIIAHERESREKGQKRPSDGNSGLIAKKQKRTPKRTSAAAKTE--KNGAGQS 1112

  Fly  1444 ILEHQSPAAGRERGGYGGMTSS-----ISLLTAPKLKK------RGSP-LKEAALCMEKAK---- 1492
            ......||          |.||     :..||.||.:|      |.|| :|:|    ||.|
Mouse  1113 SDSEDLPA----------MDSSSNCTPVKRLTLPKSQKLPRSPARTSPHIKDA----EKEKHREK 1163

  Fly  1493 -------TYK-------LDKDQVQQPVE--QKTQQLIQPTLGPVESYGAGSPEAMSNLSTPTTSS 1541
                   |||       ||.....:.:.  |:..|.|:.....::|..|........|.......
Mouse  1164 HPNSSPRTYKWSFQLNELDNMNSTERISFLQEKLQEIRKYYMSLKSEVATIDRRRKRLKKKDREV 1228

  Fly  1542 GHAQLSASSTYSQ--LTPHHATP 1562
            .||..|.||..|.  ::|..::|
Mouse  1229 SHAGASMSSASSDTGMSPSSSSP 1251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	29/94 (31%)
		ARID	299..381	CDD:279697	35/82 (43%)
		Tudor-knot	692..751	CDD:288553	25/61 (41%)
Arid4a	NP_001074664.1	DNA-binding. {ECO:0000250|UniProtKB:P29374}	4..121		72/121 (60%)
		TUDOR	58..113	CDD:197660	35/59 (59%)
		RBB1NT	175..261	CDD:311890	28/90 (31%)
		BRIGHT	312..401	CDD:128777	36/89 (40%)
		Chromodomain-like. {ECO:0000250|UniProtKB:P29374}	571..638		29/71 (41%)
		Tudor-knot	578..632	CDD:314560	26/58 (45%)
		Rabaptin	<778..937	CDD:308892	34/176 (19%)
		Retinoblastoma protein binding. {ECO:0000250|UniProtKB:P29374}	955..968		6/36 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C104880154
eggNOG	1	0.900				E1_KOG2744
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1746
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0001641
OrthoInspector	1	1.000				T616969
orthoMCL	1	0.900				OOG5_131238
Panther	1	1.100			LDO	PTHR13964
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1374
TreeFam	1	0.960
	10	9.870