Protein Alignment htk and ARID3A

DIOPT Version :10

• Sequence 1: NP_573330.3
• Gene: htk / 32877
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: NP_005215.1
• Gene: ARID3A / 1820
• HGNCID: 3031
• Length: 593
• Species: Homo sapiens
• Alignment Length: 807
• Identity: 164/807 - (20%)
• Similarity: 261/807 - (32%)
• Gaps: 274/807 - (33%)

  Fly    54 DAIKAPTGQLRVGAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHF 118
            |...||.|:.| .|..|.|.|:...:..|.:..               :..:|..|..|  |...
Human    30 DPPAAPPGRAR-AAPDEDREPESARMQRAQMAA---------------LAAMRAAAAGL--GHPA 76

  Fly   119 NESETLDQLPLTHPEHF------GNPVVG-GRRGRRRGHLNEDSSEDDD----------ESDAKE 166
            :...:.|..|.:..|..      |:|  | ||.|....|. ||.:.|:|          |.|..|
Human    77 SPGGSEDGPPGSEEEDAAREGTPGSP--GRGREGPGEEHF-EDMASDEDMKPKWEEEEMEEDLGE 138

  Fly   167 VVNEKEENIGKVVCVETESKKKDKEKWFPALVVAPTAQATVRIRVKDEYLVRSFK-DGRYYTVPK 230
            ...|:||:      .|.|.:::|:|...|.   .|.:..|..:..:.....::|: ||    ||:
Human   139 DEEEEEED------YEDEEEEEDEEGLGPP---GPASLGTTALFPRKAQPPQAFRGDG----VPR 190

  Fly   231 KEATEFTREVASKQDVPAVQAALEFLDSSVLPAHWDRDSLFGLTNISSDDEG------------E 283
                     |...|:.|....|.....:.|.|            .:...|.|            |
Human   191 ---------VLGGQERPGPGPAHPGGAAHVAP------------QLQPPDHGDWTYEEQFKQLYE 234

  Fly   284 IDSDSSDDEPHEEKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQN 348
            :|.|       .::..|:..|:.:|..||||:|::|.:..:.:||:.|:..|.::||...|.::.
Human   235 LDGD-------PKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKK 292

  Fly   349 QWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFHRKL-GCSMLMTSRNSNRSKGRSLVRANS 412
            .|:.|...|.......|....::..|.|:|.||....|.| ..:.|..:.:|||.:||......|
Human   293 LWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGS 357

  Fly   413 VASPKPMETMKTETISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSE 477
            :.:..|                             ..:....|:|...||:...:|     :|:.
Human   358 LFAYSP-----------------------------GGAHGMLSSPKLPVSSLGLAA-----STNG 388

  Fly   478 SSVVVEPPKKQRKGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAA 542
            ||:...|               |:|      :|:.:|:..|..|.:     ..|.|..|..:|
Human   389 SSITPAP---------------KIK------KEEDSAIPITVPGRL-----PVSLAGHPVVAA-- 425

  Fly   543 STATNLSSATSGGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASS 607
                                               :||||.||                :|.|:.
Human   426 -----------------------------------QAAAVQAA----------------AAQAAV 439

  Fly   608 KANSAEMQRSRDASPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQASS 672
            .|.:|.:::.|:...|...|....|..:             ::.||..|...:::......|...
Human   440 AAQAAALEQLREKLESAEPPEKKMALVA-------------DEQQRLMQRALQQNFLAMAAQLPM 491

  Fly   673 GKRKKEKISVEKIDTGDFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYLVHYTG 737
            ..|...:.|..:.|:...:.|                ::||.        |:...|.:..:.|||
Human   492 SIRINSQASESRQDSAVNLTG----------------TNGSN--------SISMSVEINGIMYTG 532

  Fly   738 WNNRYDEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQ 802
                               ....|......||:.|.|.|||||.....||.||.
Human   533 -------------------VLFAQPPAPTPTSAPNKGGGGGGGSSSNAGGRGGN----------- 567

  Fly   803 PPGVSDKQPGKDGCSKMSPSSGNSTGP 829
             .|.|..|.|..|.|..|.|:.|::.|
Human   568 -TGTSGGQAGPAGLSTPSTSTSNNSLP 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	Tudor_ARID4_rpt1	10..60	CDD:410460	2/5 (40%)
		Tudor_ARID4_rpt2	65..118	CDD:410461	9/52 (17%)
		RBB1NT	170..263	CDD:462390	20/93 (22%)
		ARID	296..381	CDD:460187	23/84 (27%)
		CBD_RBP1_like	698..758	CDD:350843	7/59 (12%)
ARID3A	NP_005215.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..222		53/246 (22%)
		Acidic	119..156		10/42 (24%)
		ARID_ARID3A	219..351	CDD:350642	37/138 (27%)
		Important for nuclear localization. /evidence=ECO:0000250	445..488		7/55 (13%)
		Homodimerization	490..513		4/38 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..516		3/34 (9%)
		Important for cytoplasmic localization. /evidence=ECO:0000250	537..557		9/19 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	539..593		22/65 (34%)