DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and ARID3A

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_005215.1	Gene:	ARID3A / 1820	HGNCID:	3031	Length:	593	Species:	Homo sapiens

Alignment Length:	812	Identity:	167/812 - (20%)
Similarity:	263/812 - (32%)	Gaps:	284/812 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DAIKAPTGQLRVGAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHF 118
            |...||.|:.| .|..|.|.|:...:..|.:..               :..:|..|..|  |...
Human    30 DPPAAPPGRAR-AAPDEDREPESARMQRAQMAA---------------LAAMRAAAAGL--GHPA 76

  Fly   119 NESETLDQLPLTHPEHF------GNPVVG-GRRGRRRGHLNEDSSEDDD----------ESDAKE 166
            :...:.|..|.:..|..      |:|  | ||.|....|. ||.:.|:|          |.|..|
Human    77 SPGGSEDGPPGSEEEDAAREGTPGSP--GRGREGPGEEHF-EDMASDEDMKPKWEEEEMEEDLGE 138

  Fly   167 VVNEKEENIGKVVCVETESKKKDKEKWFPALVVAPTAQATVRIRVKDEYLVRSFK-DGRYYTVPK 230
            ...|:||:      .|.|.:::|:|...|.   .|.:..|..:..:.....::|: ||    ||:
Human   139 DEEEEEED------YEDEEEEEDEEGLGPP---GPASLGTTALFPRKAQPPQAFRGDG----VPR 190

  Fly   231 KEATEFTREVASKQDVPAVQAALEFLDSSVLPAHWDRDSLFGLTNISSDDEG------------E 283
                     |...|:.|....|.....:.|.|            .:...|.|            |
Human   191 ---------VLGGQERPGPGPAHPGGAAHVAP------------QLQPPDHGDWTYEEQFKQLYE 234

  Fly   284 IDSDSSDDEPHEEKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQN 348
            :|.|       .::..|:..|:.:|..||||:|::|.:..:.:||:.|:..|.::||...|.::.
Human   235 LDGD-------PKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKK 292

  Fly   349 QWKLIAMRLGFTPCTVSVMNLVKQAYKKFLQPYGDFHRKL-GCSMLMTSRNSNRSKGRSLVRANS 412
            .|:.|...|.......|....::..|.|:|.||....|.| ..:.|..:.:|||.:||......|
Human   293 LWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECEKRGLSNPNELQAAIDSNRREGRRQSFGGS 357

  Fly   413 VASPKPMETMKTETISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSE 477
            :.:..|                             ..:....|:|...||:...:|     :|:.
Human   358 LFAYSP-----------------------------GGAHGMLSSPKLPVSSLGLAA-----STNG 388

  Fly   478 SSVVVEPPKKQRKGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAA 542
            ||:...|               |:|      :|:.:|:..|..|.:     ..|.|..|..:|
Human   389 SSITPAP---------------KIK------KEEDSAIPITVPGRL-----PVSLAGHPVVAA-- 425

  Fly   543 STATNLSSATSGGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASS 607
                                               :||||.||                :|.|:.
Human   426 -----------------------------------QAAAVQAA----------------AAQAAV 439

  Fly   608 KANSAEMQRSRDASPSVAAPPSAGASTSGAAATAQTASNKK-----EKHQRSKQADKEKDKDKEE 667
            .|.:|.:::.|:...| |.||                 .||     ::.||..|...:::.....
Human   440 AAQAAALEQLREKLES-AEPP-----------------EKKMALVADEQQRLMQRALQQNFLAMA 486

  Fly   668 KQASSGKRKKEKISVEKIDTGDFVVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISVQRGVPMYL 732
            .|.....|...:.|..:.|:...:.|                ::||.        |:...|.:..
Human   487 AQLPMSIRINSQASESRQDSAVNLTG----------------TNGSN--------SISMSVEING 527

  Fly   733 VHYTGWNNRYDEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLL 797
            :.|||                   ....|......||:.|.|.|||||.....||.||.
Human   528 IMYTG-------------------VLFAQPPAPTPTSAPNKGGGGGGGSSSNAGGRGGN------ 567

  Fly   798 VQGSQPPGVSDKQPGKDGCSKMSPSSGNSTGP 829
                  .|.|..|.|..|.|..|.|:.|::.|
Human   568 ------TGTSGGQAGPAGLSTPSTSTSNNSLP 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	19/91 (21%)
		ARID	299..381	CDD:279697	23/81 (28%)
		Tudor-knot	692..751	CDD:288553	8/58 (14%)
ARID3A	NP_005215.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..222		53/246 (22%)
		Acidic	119..156		10/42 (24%)
		BRIGHT	239..331	CDD:128777	25/91 (27%)
		Important for nuclear localization. /evidence=ECO:0000250	445..488		10/60 (17%)
		Homodimerization	490..513		4/38 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..516		3/34 (9%)
		Important for cytoplasmic localization. /evidence=ECO:0000250	537..557		9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..593		22/65 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840