DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htk and cec-7

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_001022827.1	Gene:	cec-7 / 176704	WormBaseID:	WBGene00012551	Length:	499	Species:	Caenorhabditis elegans

Alignment Length:	409	Identity:	105/409 - (25%)
Similarity:	152/409 - (37%)	Gaps:	83/409 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 ETISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESS---VVVEPPK 486
            :|.|..|..|.|:  :..:..||.|..|.....|:.|..:|..||:......|||   :.|:||.
Worm    94 QTASSSADSNGTS--SGATEKAAKAPAATMRKSAKKVDESSSEAADPKAKAEESSQNALKVDPPL 156

  Fly   487 KQRKGSAASSQ-QGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTS-----AAASTA 545
            ..||.|..::: .|.:|.|....|.:..|.:.|         ....|...|..|     |..|||
Worm   157 TTRKSSRTTTEATGAMKRLTVAQETEDEAPKET---------VQKKARIEPVDSAEESKAKGSTA 212

  Fly   546 TNLSSATS-GGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSME-----KETNISSGSSAS 604
            ....||.. |.|.:.||....|..||.....|::.......|:|.::|     |...::..:...
Worm   213 PMRKSAKKVGESNSEATDPEAKAKESSQSALKVEPPLTTHNSSRKTVEATGAMKRLTVAKETEDE 277

  Fly   605 ASSKANSAEMQRSRDASPS--VAAPPSA--------GASTSGAAAT-----AQTASNKKEKHQRS 654
            |......|.::...|||.:  .|||.||        .:||:.||.|     ...|...|.|...:
Worm   278 ALKSQKKARIEPVEDASKAKGSAAPKSASSRAEDGESSSTNDAAGTRFVIGELVACTYKGKVYDA 342

  Fly   655 KQADKEKDKDKEEKQASSGK----RKKEKISVEKIDTGDFVVGIGD---------KLKVNYHEKK 706
            ...|.:.|||.:|......|    |..|:|.:.: :|.....||.|         :.....|||.
Worm   343 VITDIKPDKDGKECYCIHFKGWNNRYDEQIPIGE-ETDRIFKGIADGYRAPVVTMRKSARNHEKS 406

  Fly   707 SP---------------------------SSHGSTYEAKVIEISVQR-GVPMYLVHYTGWNNRYD 743
            :.                           :.:|..|:|.:::|.... |...|.||:.|||:|||
Worm   407 TEPQATKENAPRLVGKRREQFIIGEQVTCTQNGKPYDAYIVDIITDTDGKDFYCVHFKGWNSRYD 471

  Fly   744 EWVPRERIAENLTKGSKQK 762
            |.:|.......|.|||..|
Worm   472 EKIPVGEEQGRLFKGSAAK 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392
		ARID	299..381	CDD:279697
		Tudor-knot	692..751	CDD:288553	22/95 (23%)
cec-7	NP_001022827.1	CHROMO	30..>56	CDD:214605
		CHROMO	344..>374	CDD:214605	9/29 (31%)
		Tudor-knot	427..476	CDD:288553	15/48 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I8513
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1624495at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010