DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htk and MSL3

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	NP_523353.2	Gene:	MSL3 / 10943	HGNCID:	7370	Length:	521	Species:	Homo sapiens

Alignment Length:	463	Identity:	90/463 - (19%)
Similarity:	150/463 - (32%)	Gaps:	133/463 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   695 GDKLKVNYHEK-----KSPSSHGSTYEAKVIEISV-----QRGVPMYLVHYTGWNNRYDEWVPRE 749
            |.|.|.:..||     ..|:.....|:||::::.|     .|.:|.||:|:.|||..:|.|...:
Human     6 GMKFKFHSGEKVLCFEPDPTKARVLYDAKIVDVIVGKDEKGRKIPEYLIHFNGWNRSWDRWAAED 70

  Fly   750 RIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVSDKQ---P 811
            .:..: |..:::..|.::..:                           |...:..|...|:   |
Human    71 HVLRD-TDENRRLQRKLARKA---------------------------VARLRSTGRKKKRCRLP 107

  Fly   812 GKDGCSKMSPSSGNSTGPGAPSLSGSLGGASSTPSLLS--------TVVKTPPTGGAKR------ 862
            |.|...|..|:...... ...|||.|...:.:....:|        |.||..|....:|
Human   108 GVDSVLKGLPTEEKDEN-DENSLSSSSDCSENKDEEISEESDIEEKTEVKEEPELQTRREMEERT 171

  Fly   863 ---------------------GRGRSDSMPPRS---TTPSSVVAHSGRTKSPAASQPQLQQQMKK 903
                                 .|.|...:|.::   |...|.|.|.....:.:|::       :.
Human   172 ITIEIPEVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANE-------RP 229

  Fly   904 RPTRVVPGTTTPRRVSDASMASESDSDSDEPVR------------RPKRQSAKDKPQAGKAQPPG 956
            |...|:|..........|....:...:..:.:|            .|..|:...|..:.|...|
Human   230 RHHHVMPHANMNVHYIPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQAQYKKVTSSKFFLP- 293

  Fly   957 KGRLASSASST-------APAAHPSDDSEEDEEEEEPSAARAASSKQQQQQASSL----RGSRAG 1010
               :..||:||       :|:....:.|.....|.:|:....|:.|:::.:..:|    |.:|..
Human   294 ---IKESATSTNRSQEELSPSPPLLNPSTPQSTESQPTTGEPATPKRRKAEPEALQSLRRSTRHS 355

  Fly  1011 GN---RAMSSGAASAKGRDYDLSEIRSELKGFQPKLLTNAASNEERKDLAKKEPSDEPALQDIKK 1072
            .|   .:.||.:...|.|..|.|       ...|||..:         |.||.|....:...|..
Human   356 ANCDRLSESSASPQPKRRQQDTS-------ASMPKLFLH---------LEKKTPVHSRSSSPIPL 404

  Fly  1073 EPKLESSA 1080
            .|..|.||
Human   405 TPSKEGSA 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392
		ARID	299..381	CDD:279697
		Tudor-knot	692..751	CDD:288553	20/65 (31%)
MSL3	NP_523353.2	CBD_MSL3_like	15..81	CDD:350846	18/66 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..166		11/52 (21%)
		MRG	156..506	CDD:399022	53/284 (19%)
		Required for the histone acetyltransferase activity of the MSL complex	290..440		33/143 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..409		28/126 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1624495at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010