Protein Alignment htk and arid4b

DIOPT Version :10

• Sequence 1: NP_573330.3
• Gene: htk / 32877
• FlyBaseID: FBgn0085451
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_005173089.2
• Gene: arid4b / 100537923
• ZFINID: ZDB-GENE-160607-1
• Length: 1240
• Species: Danio rerio
• Alignment Length: 1746
• Identity: 427/1746 - (24%)
• Similarity: 630/1746 - (36%)
• Gaps: 621/1746 - (35%)

  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:.:::||.|.|||:|||||:|||||||:....|.:|.||.::....:..|.|:.|:   |.|:|
Zfish     1 MKTLEEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKAKVTFRPDASTAEVHDEHIR---GLLKV 62

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            |||||.|:.| ....||||.|:.|.|.|||||||||..||||::||||..|||.||||||:||||
Zfish    63 GAVVEARNQD-GVYQEATINKLTDASLYTVVFDDGDEKTLRRSSLCLKGARHFAESETLDRLPLT 126

  Fly   131 HPEHFGNPVVG--GRRGRRRGH-LNED----SSEDDDESDAKEVVNEKEENIGKVVCVE---TES 185
            :|||||.||:|  |.||.||.: :.|:    ||.:::|.|.:    :.||..|||||||   |..
Zfish   127 NPEHFGTPVIGKKGNRGGRRSNPIQEEESSSSSSEEEEGDQQ----QNEELYGKVVCVEGVLTND 187

  Fly   186 KKKDKEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDV---P 247
            ||  |..|:||||::|.....|.:: ||...|||||||::|||.:|:..|...:.|.|.|.   |
Zfish   188 KK--KSTWYPALVISPDCHEDVTLK-KDNVFVRSFKDGKFYTVLRKDIRELDEDKAPKADAGLKP 249

  Fly   248 AVQAALEFLDSSVLPAHW-----DRDSLFGLTNISSDDEGEIDSDSSDDEPH------------E 295
            |:.||.||..:..:|..|     |..|       ||:||.|.:.:..::|..            |
Zfish   250 ALDAAWEFQRNGAVPNTWRTEVKDESS-------SSEDEEEEEEEEQEEEASSEEEEEEVEPFPE 307

  Fly   296 EKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFT 360
            |||.|:.||||:|:|||||:||.|.:..::::|::|:|.|.|.||::.:.|.:.||.:...||
Zfish   308 EKDNFLQQLYKFMEDRGTPINKRPVLGYKNLNLFKLYRLVHKLGGFDNIESGSVWKQVYQDLG-- 370

  Fly   361 PCTVSVMNL-----VKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPME 420
               :.|:|.     ||.||:|:|..:.|:....|.|.
Zfish   371 ---IPVLNSAAGYNVKCAYRKYLYGFEDYCTSTGISF---------------------------- 404

  Fly   421 TMKTETISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPP 485
                    ::..|.:|....|..:...|..|         :||             |::|.:..|
Zfish   405 --------RMDLPYKTGEKTSCKTEVKAEEV---------IST-------------ENTVSLNTP 439

  Fly   486 KKQRKGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSS 550
            ::.             ||:.|  .|:|
Zfish   440 EEH-------------KSITE--SERS-------------------------------------- 451

  Fly   551 ATSGGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEMQ 615
                                               .|||.:::|
Zfish   452 -----------------------------------CTRHLLKEE--------------------- 460

  Fly   616 RSRDASPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQA-SSGKRK--- 676
                 ......|....|..||        .||:::    |.|::|.:.::|.||. |:|:..
Zfish   461 -----KTETVTPCEEKADISG--------ENKEDE----KHAEEENEMNEEVKQCMSTGETDVTE 508

  Fly   677 --KEKISVEKID---TGDF------------VVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISV 724
              ||:...|..|   :||.            ....|.|::|.|...:|.    .||:|.|.|.::
Zfish   509 DVKEEPCEEPDDKDLSGDVSSQEWEEGQEFECYPPGMKVQVRYGRGRSL----KTYDATVKESNL 569

  Fly   725 QRGVPMYLVHYTGWNNRYDEWVPRERIAENLTKGSKQKTRTISTSSANSGSGGGGGGGGGGGGGG 789
            :.|..:|||||.|||.|||||:..::|.....|
Zfish   570 EGGEVLYLVHYCGWNVRYDEWIKADKIVRPANK-------------------------------- 602

  Fly   790 GGGGGSLLVQGSQPPGVSDKQPGKDGCSKMSPSSGNSTGPGAPSLSGSLGGASSTPSLLSTVVKT 854
                        ..|.:..::..|:
Zfish   603 ------------NVPKIKHRKKIKN---------------------------------------- 615

  Fly   855 PPTGGAKRGRGRSDSMPPRSTTPSSVVAHSGRTKSPAASQPQLQQQMKKRPTRVVPGTTTPRRVS 919
                .|:|.|.|.:.:..|...|||                      |.|          ..|:|
Zfish   616 ----KAERERDRIERLADREDLPSS----------------------KNR----------INRLS 644

  Fly   920 DASMASESDSDSDEPVRRPKRQSAKDKPQAGKAQPPGKGRLASSASSTAPAAHPSD-DSEEDEEE 983
            ..:...:..|..:|.|.:..:||.:.....        ..|..|.|||..:....| |::.||::
Zfish   645 KVNSGGDVFSKMEECVDKGNQQSIEITSIL--------NGLPGSDSSTDDSEREEDEDADHDEDD 701

  Fly   984 EEPSAARAASSKQQQQQASSLRGSRAGGNRAMSSGAASAKGRDYDLSEIRSELKGFQPKLLTNAA 1048
            :.|.|.:|...:.|..:.:|
Zfish   702 DHPGAHKADPPQSQHWEKNS--------------------------------------------- 721

  Fly  1049 SNEERKDLAKKEPSD---EPALQDIKKEPKLESSAKSSSTELSSETESYADEDSQSSDYRKQLKG 1110
            |..|    |.|.|:|   ||.|||..:.||    .|...|..|:.....| |::..|..:.:.:.
Zfish   722 SPPE----APKTPADAEQEPTLQDSTETPK----RKELDTNASAGRRKKA-ENTSKSPAKGKTRN 777

  Fly  1111 SGAGKKEPTASPSKLHHEPVTKRELAVKEEPLKIEPKTEPKEEETKSKPFLSGADIKPTALIA-- 1173
            |..|:...:.||.||...         .|...:.|||..||.:.:.||.: :|...|..:..|
Zfish   778 SRGGEWLQSGSPKKLEDR---------GESSSEDEPKGHPKNKSSPSKKY-NGVKEKSKSRGAFW 832

  Fly  1174 --PARFGNTSAAQAASSSGSSSTTAK--YTSVIVEKPLTIGGKKSVEQHVPKKAELLKKQSGGAG 1234
              |.:....||.....|.|..:...|  ::|:.|:.|     ||::::...............||
Zfish   833 EIPEKRAKVSAGIEERSPGCRTKGQKDVWSSIQVQWP-----KKTLKELFSDSDTEAANSPPPAG 892

  Fly  1235 GTAASSSAASQESKKFAEPVASLKVEMPAACSPSSSSSSSSSFCSTGSAVSSSSATRSLPDMSKL 1299
            ..|.|.||..:|.::..|....   |.|        ||.::|..:|......|.|....|..:..
Zfish   893 PEACSESARDEEEEEEEEEKLQ---EHP--------SSGTNSVLNTPPTTPESPAAAEGPAETLP 946

  Fly  1300 EISSGTVP---GATPGAAALQPSNVAQVSSSGAAKESKYSSSGGAAAGSGISMRKLLSSDVYEFK 1361
            |:.:.:.|   .|:|...:| |........:|...||
Zfish   947 EVRAPSPPAALAASPPPVSL-PEEPLMEEPAGGRSES---------------------------- 982

  Fly  1362 DTEPFEFEKRISPMASVGGTVAAAATAAGAMAAAGAASVITTMVPTPGASGSGVAASASTSAPVV 1426
            |:...|.|       |:||.:..      ..|..||.|      |:....|:....|.|..:..:
Zfish   983 DSSTVEVE-------SLGGEIQE------MNAEEGAGS------PSKAFDGNMSCNSNSNCSLTL 1028

  Fly  1427 VGSAARKQALKASAIQHILEHQSPAAGRERGGYGGMTSSISLLTAPKLKKRGSPLKEAALCMEKA 1491
            ..|:.::...||.|......|      :|..| ||.|           ||.....|..:|..:|:
Zfish  1029 SNSSQQESEQKAKASSSQKRH------KESQG-GGAT-----------KKHKRSHKNLSLQPKKS 1075

  Fly  1492 KTYKLDKDQVQQPVEQKTQQLIQPTLGPVESYGAGSPEAMSNLSTPTTSSGHAQLSASSTY--SQ 1554
            :......|...|.:.:.|               |.||        |..||| |:|.:|.|:  |.
Zfish  1076 RKAAHSSDSEDQCISEST---------------AKSP--------PVKSSG-AELKSSITHKCSS 1116

  Fly  1555 LTP---------HHATPFDALRKSPSFNLN----------ITALNEELAQTVQETTRALTDAL-- 1598
            .||         |..|.....|...||.::          |:.|.|:| |.::.....|...:
Zfish  1117 RTPPSGQQRYHKHTDTEHSHGRTRWSFQMSDLEKMSSLERISFLQEKL-QDIRNHYLLLKSEVAS 1180

  Fly  1599 ----------QPPSTPVPPTVSASGSTP-----TAVTPVITAMPTAG----TAGLS 1635
                      :...|......|:|.|:|     ||...:..|.||..    |||:|
Zfish  1181 IDRRRKRIKKKERETGAAAASSSSSSSPSSSSLTAAVMLTLAEPTVSAASQTAGVS 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	Tudor_ARID4_rpt1	10..60	CDD:410460	23/49 (47%)
		Tudor_ARID4_rpt2	65..118	CDD:410461	33/52 (63%)
		RBB1NT	170..263	CDD:462390	43/98 (44%)
		ARID	296..381	CDD:460187	37/89 (42%)
		CBD_RBP1_like	698..758	CDD:350843	23/59 (39%)
arid4b	XP_005173089.2	None