DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htk and arid4b

DIOPT Version :9

Sequence 1:	NP_573330.3	Gene:	htk / 32877	FlyBaseID:	FBgn0085451	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	XP_005173089.1	Gene:	arid4b / 100537923	ZFINID:	ZDB-GENE-160607-1	Length:	1240	Species:	Danio rerio

Alignment Length:	1559	Identity:	402/1559 - (25%)
Similarity:	585/1559 - (37%)	Gaps:	494/1559 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQQMDDPPSLPVGTEVSAKYKGAFCEAKVSKVVRNIKVKVAYKQGLGSGIVSDDAIKAPTGQLRV 65
            |:.:::||.|.|||:|||||:|||||||:....|.:|.||.::....:..|.|:.|:   |.|:|
Zfish     1 MKTLEEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKAKVTFRPDASTAEVHDEHIR---GLLKV 62

  Fly    66 GAVVEVRHPDRKELVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFNESETLDQLPLT 130
            |||||.|:.| ....||||.|:.|.|.|||||||||..||||::||||..|||.||||||:||||
Zfish    63 GAVVEARNQD-GVYQEATINKLTDASLYTVVFDDGDEKTLRRSSLCLKGARHFAESETLDRLPLT 126

  Fly   131 HPEHFGNPVVG--GRRGRRRGH-LNED----SSEDDDESDAKEVVNEKEENIGKVVCVE---TES 185
            :|||||.||:|  |.||.||.: :.|:    ||.:::|.|.:    :.||..|||||||   |..
Zfish   127 NPEHFGTPVIGKKGNRGGRRSNPIQEEESSSSSSEEEEGDQQ----QNEELYGKVVCVEGVLTND 187

  Fly   186 KKKDKEKWFPALVVAPTAQATVRIRVKDEYLVRSFKDGRYYTVPKKEATEFTREVASKQDV---P 247
            ||  |..|:||||::|.....|.:: ||...|||||||::|||.:|:..|...:.|.|.|.   |
Zfish   188 KK--KSTWYPALVISPDCHEDVTLK-KDNVFVRSFKDGKFYTVLRKDIRELDEDKAPKADAGLKP 249

  Fly   248 AVQAALEFLDSSVLPAHW-----DRDSLFGLTNISSDDEGEIDSDSSDDEPH------------E 295
            |:.||.||..:..:|..|     |..|       ||:||.|.:.:..::|..            |
Zfish   250 ALDAAWEFQRNGAVPNTWRTEVKDESS-------SSEDEEEEEEEEQEEEASSEEEEEEVEPFPE 307

  Fly   296 EKDRFVAQLYKYMDDRGTPLNKVPSILSRDVDLYRLFRAVQKRGGYNRVTSQNQWKLIAMRLGFT 360
            |||.|:.||||:|:|||||:||.|.:..::::|::|:|.|.|.||::.:.|.:.||.:...||
Zfish   308 EKDNFLQQLYKFMEDRGTPINKRPVLGYKNLNLFKLYRLVHKLGGFDNIESGSVWKQVYQDLG-- 370

  Fly   361 PCTVSVMNL-----VKQAYKKFLQPYGDFHRKLGCSMLMTSRNSNRSKGRSLVRANSVASPKPME 420
               :.|:|.     ||.||:|:|..:.|:....|.|.
Zfish   371 ---IPVLNSAAGYNVKCAYRKYLYGFEDYCTSTGISF---------------------------- 404

  Fly   421 TMKTETISKLAQPNQTNVVASTSSSAAAASVAASSTPARAVSTASQSAAEESGNTSESSVVVEPP 485
                    ::..|.:|...||..:...|..|.:                  :|||    |.:..|
Zfish   405 --------RMDLPYKTGEKASCKTEVKAEEVIS------------------AGNT----VSLNTP 439

  Fly   486 KKQRKGSAASSQQGKVKSLVEKYEEKSTAVQATSSGTVAGSGASASAAAMPTTSAAASTATNLSS 550
            ::.             ||:.|  .|:|
Zfish   440 EEH-------------KSITE--SERS-------------------------------------- 451

  Fly   551 ATSGGSATIATTAMNKDAESDLPLAKIKAAAVAAASTRHSMEKETNISSGSSASASSKANSAEMQ 615
                                               .|||.:::|
Zfish   452 -----------------------------------CTRHLLKEE--------------------- 460

  Fly   616 RSRDASPSVAAPPSAGASTSGAAATAQTASNKKEKHQRSKQADKEKDKDKEEKQA-SSGKRK--- 676
                 ......|....|..||        .||:::    |.|::|.:.::|.||. |:|:..
Zfish   461 -----KTETVTPCEEKADISG--------ENKEDE----KHAEEENEMNEEVKQCMSTGETDVTE 508

  Fly   677 --KEKISVEKID---TGDF------------VVGIGDKLKVNYHEKKSPSSHGSTYEAKVIEISV 724
              ||:...|..|   :||.            ....|.|::|.|...:|.    .||:|.|.|.::
Zfish   509 DVKEEPCEEPDDKDLSGDVSSQEWEEGQEFECYPPGMKVQVRYGRGRSL----KTYDATVKESNL 569

  Fly   725 QRGVPMYLVHYTGWNNRYDEWVPRERIAENLTKG------------------------------S 759
            :.|..:|||||.|||.|||||:..::|.....|.                              .
Zfish   570 EGGEVLYLVHYCGWNVRYDEWIKADKIVRPANKNVPKIKHRKKIKNKAERERDRIERLADREDLP 634

  Fly   760 KQKTRTISTSSANSGSGGGGGGGGGGGGGGGGGGGSLLVQGSQPPGVSDKQPGKDGCSKMSP--S 822
            ..|.|....|..|||.                                      |..|||..  .
Zfish   635 SSKNRINRLSKVNSGG--------------------------------------DVFSKMEECVD 661

  Fly   823 SGNSTGPGAPSLSGSLGGASSTPSLLSTVVKTPPTGGAKR---------------GRGRSDSMPP 872
            .||.......|:...|.|:.|:            |..::|               |..::|  ||
Zfish   662 KGNQQSIEITSILNGLPGSDSS------------TDDSEREEDEDADHDEDDDHPGAHKAD--PP 712

  Fly   873 RSTTPSSVVAHSGRTKSPAASQPQLQQQMKKRPTRVVPGTTTPRRVSDASMASESDSDSDEPVRR 937
            :|       .|..:..||..: |:.....::.|| :...|..|:|       .|.|:|:... ||
Zfish   713 QS-------QHWEKNSSPPEA-PKTPADAEQEPT-LQDSTEAPKR-------KELDTDASAG-RR 760

  Fly   938 PKRQSAKDKPQAGKAQPPGKGR------------LASSASSTAPAAHPSDDSEEDEE---EEEPS 987
            .|.::....|..||.:....|.            ...|:|...|..||.:.|...::   .:|.|
Zfish   761 KKAENTSKSPAKGKTRNSRGGEWLQSGSPKKLEDRGESSSEDEPKGHPKNKSSPSKKYNGVKEKS 825

  Fly   988 AARAASSKQQQQQASSLRG--SRAGGNRAMSSGAASAKGRDYDLSEIRSELKGFQPKLLTNAASN 1050
            .:|.|..:..:::|....|  .|:.|.|        .||:    .::.|.::...||.......:
Zfish   826 KSRGAFWEIPEKRAKVSAGIEERSPGCR--------TKGQ----KDVWSSIQVQWPKKTLKELFS 878

  Fly  1051 EERKDLAKKEPSDEPALQDIKKEPKLESSAKSSSTELSSETESYADEDSQSSDYRKQLKGSGAGK 1115
            :...:.|...|...|           |:.::|:..|...|.|....::..||.....|.......
Zfish   879 DSDTEAANSPPPAGP-----------EACSESARDEEEEEEEEEKLQEHPSSGTNSVLNTPPTTP 932

  Fly  1116 KEPTAS--PSKLHHE---PVTKRELA-------VKEEPLKIEPKTEPKEEETKSKPFLS-GADIK 1167
            :.|.|:  |:::..|   |.....||       :.||||..||.....|.::.:....| |.:|:
Zfish   933 ESPAAAEGPAEILPEVRAPSPPAALAASPPPVSLPEEPLMEEPAGGRSESDSSTVEVESLGGEIQ 997

  Fly  1168 ----PTALIAPARF----------GNTSAAQAASSSGSSSTTAKYTSVIVEKPLTIGG---KKSV 1215
                .....:|::.          .|.|...:.||...|...||.:|.......:.||   ||..
Zfish   998 EMNAEEGAGSPSKAFDGNMSCNSNSNCSLTLSNSSQQESEQKAKASSSQKRHKESQGGGATKKHK 1062

  Fly  1216 EQHVPKKAELLKKQSGGAGGTAASSSAASQESKKFAEPV----ASLKVEMPAACSPSSSSSSSSS 1276
            ..|  |...|..|:|..|..::.|......||...:.||    |.||..:...||..:..|....
Zfish  1063 RSH--KNLSLQPKKSRKAAHSSDSEDQCISESTAKSPPVKSSGAELKSSITHKCSSRTPPSGQQR 1125

  Fly  1277 FCSTGSAVSSSSATRSLPDMSKLEISSGTVPGATPGAAALQ-------------PSNVAQVSSSG 1328
            :........|...||....||.||..|     :....:.||             .|.||.:....
Zfish  1126 YHKHTDTEHSHGRTRWSFQMSDLEKMS-----SLERISFLQEKLQDIRNHYLLLKSEVASIDRRR 1185

  Fly  1329 AAKESKYSSSGGAAAGSGISMRKLLSSDVYEFKDT--EPFEFEKRISPMASVGGTVAAAATAAG 1390
            ...:.|...:|.|||.|..|.....||.......|  ||               ||:||:..||
Zfish  1186 KRIKKKERETGAAAASSSSSSSPSSSSLTAAVMLTLAEP---------------TVSAASQTAG 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htk	NP_573330.3	RBB1NT	171..262	CDD:285392	43/96 (45%)
		ARID	299..381	CDD:279697	34/86 (40%)
		Tudor-knot	692..751	CDD:288553	24/58 (41%)
arid4b	XP_005173089.1	TUDOR	60..109	CDD:197660	31/49 (63%)
		RBB1NT	170..264	CDD:285392	43/96 (45%)
		ARID	309..394	CDD:198082	36/89 (40%)
		Tudor-knot	543..596	CDD:288553	24/56 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594219
Domainoid	1	1.000	176	1.000	Domainoid score	I3569
eggNOG	1	0.900	-	-		E1_KOG2744
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1952
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003167
OrthoInspector	1	1.000	-	-		otm26200
orthoMCL	1	0.900	-	-		OOG6_106607
Panther	1	1.100	-	-	O	PTHR13964
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1374
SonicParanoid	1	1.000	-	-		X2560
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.780