Protein Alignment HisRS and HTS1

DIOPT Version :10

• Sequence 1: NP_573305.2
• Gene: HisRS / 32841
• FlyBaseID: FBgn0027087
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_015358.1
• Gene: HTS1 / 856145
• SGDID: S000006237
• Length: 546
• Species: Saccharomyces cerevisiae
• Alignment Length: 477
• Identity: 242/477 - (50%)
• Similarity: 319/477 - (66%)
• Gaps: 32/477 - (6%)

  Fly    83 ALKATLGGDAAPTNQKF--TLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGGEAIDTPVFELK 145
            ||||:    .||...|.  :|||||||:|:....|.:|:.:...:..:||:|||..||||||||:
Yeast    39 ALKAS----KAPKKGKLQVSLKTPKGTKDWADSDMVIREAIFSTLSGLFKKHGGVTIDTPVFELR 99

  Fly   146 EVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAKVYRRDNPAMTK 210
            |:|.|||||||||||:|:|||||:.|:|||||||.|||:|||.|.||||||||||||||.|||||
Yeast   100 EILAGKYGEDSKLIYNLEDQGGELCSLRYDLTVPFARYVAMNNIQSIKRYHIAKVYRRDQPAMTK 164

  Fly   211 GRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDGMFQACGVPADS 275
            ||.|||||||||:|||::.|:||:||:.|:.|.|.:|.|.|:.||||||::|||:||..||..:.
Yeast   165 GRMREFYQCDFDVAGTFESMVPDSECLSILVEGLTSLGIKDFKIKLNHRKILDGIFQIAGVKDED 229

  Fly   276 FRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELVEQLL-------ANEK 333
            .|.|.|||||||||||..|:|||.:|||..|..||:|||||:|:|..:.:..:|       :|||
Yeast   230 VRKISSAVDKLDKSPWEAVKKEMTEEKGQSEETADKIGEYVKLNGSLKEIHAVLSADANITSNEK 294

  Fly   334 LKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESATV--ASPA 396
            .|      :||:.:..|:||...|.:|..:|||||||||||||||:||| |:...||..  ||..
Yeast   295 AK------QGLDDIATLMKYTEAFDIDSFISFDLSLARGLDYYTGLIYE-VVTSASAPPENASEL 352

  Fly   397 KTSQQNGEQANEPATVGSVAGGGRYDNLVGMF-DPRGK---AVPCVGVSIGVERIFSVLEARAAA 457
            |...::.|.|:|...|||:|.||||||||.|| :..||   .:||||:|.|||||||:::.|..:
Yeast   353 KKKAKSAEDASEFVGVGSIAAGGRYDNLVNMFSEASGKKSTQIPCVGISFGVERIFSLIKQRINS 417

  Fly   458 SGLKLRTSDVEVYV-----ASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQ 517
            | ..::.:..:|:|     .....|...:|:||...|||||::||:.||.......|....|:..
Yeast   418 S-TTIKPTATQVFVMAFGGGKDWTGYLPERMKVTKQLWDAGIEAEYVYKAKANPRKQFDAAEKAG 481

  Fly   518 IPLVVVLGDAELAQGLVKLREV 539
            ..:.|:||..|..:|.::::.:
Yeast   482 CHIAVILGKEEYLEGKLRVKRL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:469733	4/8 (50%)
		PLN02972	<102..559	CDD:215525	234/456 (51%)
HTS1	NP_015358.1	PLN02972	<56..503	CDD:215525	234/454 (52%)