DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HisRS and HTS1

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_015358.1	Gene:	HTS1 / 856145	SGDID:	S000006237	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	477	Identity:	242/477 - (50%)
Similarity:	319/477 - (66%)	Gaps:	32/477 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 ALKATLGGDAAPTNQKF--TLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGGEAIDTPVFELK 145
            ||||:    .||...|.  :|||||||:|:....|.:|:.:...:..:||:|||..||||||||:
Yeast    39 ALKAS----KAPKKGKLQVSLKTPKGTKDWADSDMVIREAIFSTLSGLFKKHGGVTIDTPVFELR 99

  Fly   146 EVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAKVYRRDNPAMTK 210
            |:|.|||||||||||:|:|||||:.|:|||||||.|||:|||.|.||||||||||||||.|||||
Yeast   100 EILAGKYGEDSKLIYNLEDQGGELCSLRYDLTVPFARYVAMNNIQSIKRYHIAKVYRRDQPAMTK 164

  Fly   211 GRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDGMFQACGVPADS 275
            ||.|||||||||:|||::.|:||:||:.|:.|.|.:|.|.|:.||||||::|||:||..||..:.
Yeast   165 GRMREFYQCDFDVAGTFESMVPDSECLSILVEGLTSLGIKDFKIKLNHRKILDGIFQIAGVKDED 229

  Fly   276 FRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELVEQLL-------ANEK 333
            .|.|.|||||||||||..|:|||.:|||..|..||:|||||:|:|..:.:..:|       :|||
Yeast   230 VRKISSAVDKLDKSPWEAVKKEMTEEKGQSEETADKIGEYVKLNGSLKEIHAVLSADANITSNEK 294

  Fly   334 LKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESATV--ASPA 396
            .|      :||:.:..|:||...|.:|..:|||||||||||||||:||| |:...||..  ||..
Yeast   295 AK------QGLDDIATLMKYTEAFDIDSFISFDLSLARGLDYYTGLIYE-VVTSASAPPENASEL 352

  Fly   397 KTSQQNGEQANEPATVGSVAGGGRYDNLVGMF-DPRGK---AVPCVGVSIGVERIFSVLEARAAA 457
            |...::.|.|:|...|||:|.||||||||.|| :..||   .:||||:|.|||||||:::.|..:
Yeast   353 KKKAKSAEDASEFVGVGSIAAGGRYDNLVNMFSEASGKKSTQIPCVGISFGVERIFSLIKQRINS 417

  Fly   458 SGLKLRTSDVEVYV-----ASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQ 517
            | ..::.:..:|:|     .....|...:|:||...|||||::||:.||.......|....|:..
Yeast   418 S-TTIKPTATQVFVMAFGGGKDWTGYLPERMKVTKQLWDAGIEAEYVYKAKANPRKQFDAAEKAG 481

  Fly   518 IPLVVVLGDAELAQGLVKLREV 539
            ..:.|:||..|..:|.::::.:
Yeast   482 CHIAVILGKEEYLEGKLRVKRL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:294248	4/8 (50%)
		HisS	98..561	CDD:223202	236/462 (51%)
		HisRS-like_core	114..452	CDD:238396	203/350 (58%)
		HisRS_anticodon	467..557	CDD:238436	22/78 (28%)
HTS1	NP_015358.1	PLN02972	<56..503	CDD:215525	234/454 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345847
Domainoid	1	1.000	346	1.000	Domainoid score	I147
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1592
Inparanoid	1	1.050	445	1.000	Inparanoid score	I255
Isobase	1	0.950	-	0	Normalized mean entropy	S444
OMA	1	1.010	-	-		QHG55859
OrthoFinder	1	1.000	-	-		FOG0001634
OrthoInspector	1	1.000	-	-		oto99701
orthoMCL	1	0.900	-	-		OOG6_100351
Panther	1	1.100	-	-	LDO	PTHR11476
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1442
SonicParanoid	1	1.000	-	-		X1525
TreeFam	1	0.960	-	-
	16	15.740