Protein Alignment HisRS and Hars1

DIOPT Version :10

• Sequence 1: NP_573305.2
• Gene: HisRS / 32841
• FlyBaseID: FBgn0027087
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001020585.1
• Gene: Hars1 / 307492
• RGDID: 1310695
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 559
• Identity: 329/559 - (58%)
• Similarity: 398/559 - (71%)
• Gaps: 58/559 - (10%)

  Fly     1 MSDTREQILEQIKVQGDLVRQLKAAKESKEKTAPSGGGRVSSSGVPAQRQQQQQPQKQQQAQVQQ 65
            |:| |..:.|.:::||..||.||..|.|.|
  Rat     1 MAD-RAALEELVRLQGAHVRGLKEQKASAE----------------------------------- 29

  Fly    66 QQHEQLHQIDEEVARLLALKATLGGDAAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFK 130
                   ||:|||.:||.|||.||.|..  .|||.||||||||||.|:||.:|:.|.|.|::.||
  Rat    30 -------QIEEEVTKLLKLKAQLGHDEG--KQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFK 85

  Fly   131 RHGGEAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRY 195
            |||.|.||||||||||.|||||||||||||||||||||:||:|||||||.||||||||:::||||
  Rat    86 RHGAEVIDTPVFELKETLTGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRY 150

  Fly   196 HIAKVYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQ 260
            ||||||||||||||:|||||||||||||||.:|||:|||||:||:.|||.:|.||::.:|:|.|:
  Rat   151 HIAKVYRRDNPAMTRGRYREFYQCDFDIAGQFDPMIPDAECLKIMCEILSSLQIGNFQVKVNDRR 215

  Fly   261 LLDGMFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELV 325
            :|||||..||||...||||||:||||||..|.:|:.|||.||||....|||||:||:..||..||
  Rat   216 ILDGMFAVCGVPDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLV 280

  Fly   326 EQLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESA 390
            ||||.:.||.....||:||..:|.|.:|.::||:|.::|||||||||||||||||||.||
  Rat   281 EQLLQDPKLSQNKQAVEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVL----- 340

  Fly   391 TVASPAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARA 455
                 .:...|.||   ||..|||:|.|||||.|||||||:|:.|||||:|||||||||::|.:.
  Rat   341 -----LQMPTQAGE---EPLGVGSIAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQKL 397

  Fly   456 AASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIPL 520
            .||..|:||::.:|.||||.|.|.|:|||:::.|||||:|||..||.|||||.|||:|||..|||
  Rat   398 EASEEKVRTTETQVLVASAQKKLLEERLKLISELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPL 462

  Fly   521 VVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRR 559
            |.::|:.||..|::|||.||:|||.:|:.|||..|||||
  Rat   463 VAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIRRR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:469733	22/85 (26%)
		PLN02972	<102..559	CDD:215525	297/456 (65%)
Hars1	NP_001020585.1	HisRS_RNA	5..49	CDD:238474	22/85 (26%)
		PLN02972	<40..505	CDD:215525	309/477 (65%)