Protein Alignment HisRS and Hars2

DIOPT Version :10

• Sequence 1: NP_573305.2
• Gene: HisRS / 32841
• FlyBaseID: FBgn0027087
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001014034.2
• Gene: Hars2 / 307491
• RGDID: 1308426
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 482
• Identity: 266/482 - (55%)
• Similarity: 347/482 - (71%)
• Gaps: 16/482 - (3%)

  Fly    85 KATLGGD-AAPTNQK--FTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGGEAIDTPVFELKE 146
            ||.|..: ..|..||  |.:|.||||||..||||.:|:.:||||:..|||||.:.:|||.|||||
  Rat    39 KAVLTSEQLKPHQQKPNFIIKVPKGTRDLSPQQMVVREKILDKIISCFKRHGAKGLDTPAFELKE 103

  Fly   147 VLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAKVYRRDNPAMTKG 211
            :||.||.::..|:|||:|||||:||:|||||||.||||||||:..:|||.:.||:||::||:.:|
  Rat   104 MLTEKYEDNFGLMYDLEDQGGELLSLRYDLTVPFARYLAMNKLKRMKRYQVGKVWRRESPAIVQG 168

  Fly   212 RYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDGMFQACGVPADSF 276
            |||||.||||||||.:|||:|||||::|:.|||..|.:||::||:|.|:::||||..||||...|
  Rat   169 RYREFCQCDFDIAGEFDPMIPDAECLRIMCEILSGLQLGDFLIKVNDRRVVDGMFAVCGVPESKF 233

  Fly   277 RTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELVEQLLANEKLKAVPNAV 341
            |||||::|||||..|.|||.|||..|||....|||||:||:..||..|||:|..:.:|.....|:
  Rat   234 RTICSSMDKLDKMSWEDVRLEMVAGKGLAPEVADRIGDYVQCHGGISLVEELFKDPRLSQSQLAL 298

  Fly   342 KGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESATVASPAKTSQQNGEQA 406
            :||..:|.|.:|..:||:..::|.|||||||||||||||||.||      :.|||:..:
  Rat   299 QGLGDLKLLFEYLRLFGIADKISLDLSLARGLDYYTGVIYEAVL------LESPAQAGK------ 351

  Fly   407 NEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARAAASGLKLRTSDVEVYV 471
             |...|||||.|||||.||..|||:|.:|||||:||||||||.::|.:...|..|:||::.:|:|
  Rat   352 -ETLNVGSVAAGGRYDRLVAQFDPKGHSVPCVGLSIGVERIFYLVEQKMKISCEKVRTTETQVFV 415

  Fly   472 ASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIPLVVVLGDAELAQGLVKL 536
            |:..|...::|||::..|||||:|||..||.|||||.||.:||:..|||:|::|:.|..:|:|||
  Rat   416 ATPQKNFLQERLKIIAQLWDAGIKAEMLYKNNPKLLTQLHYCEKEDIPLMVIIGEQEQNEGVVKL 480

  Fly   537 REVTTREETNVKLEDLAAEIRRRQQAS 563
            |.|.:|||..|..|.|.|||::|...|
  Rat   481 RSVASREEVTVNRESLVAEIQKRLSES 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:469733	3/7 (43%)
		PLN02972	<102..559	CDD:215525	257/456 (56%)
Hars2	NP_001014034.2	PLN02972	<59..505	CDD:215525	258/458 (56%)