back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HisRS and HARS1

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_002100.2	Gene:	HARS1 / 3035	HGNCID:	4816	Length:	509	Species:	Homo sapiens

Alignment Length:	555	Identity:	327/555 - (58%)
Similarity:	396/555 - (71%)	Gaps:	57/555 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 REQILEQIKVQGDLVRQLKAAKESKEKTAPSGGGRVSSSGVPAQRQQQQQPQKQQQAQVQQQQHE 69
            |..:.|.:|:||:.||.||..|.|.|
Human     4 RAALEELVKLQGERVRGLKQQKASAE--------------------------------------- 29

  Fly    70 QLHQIDEEVARLLALKATLGGDAAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGG 134
               .|:||||:||.|||.||.|  .:.|||.||||||||||.|:||.:|:.|.|.|::.|||||.
Human    30 ---LIEEEVAKLLKLKAQLGPD--ESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGA 89

  Fly   135 EAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAK 199
            |.||||||||||.|.|||||||||||||||||||:||:|||||||.||||||||:::||||||||
Human    90 EVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAK 154

  Fly   200 VYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDG 264
            ||||||||||:|||||||||||||||.:|||:|||||:||:.|||.:|.|||:::|:|.|::|||
Human   155 VYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDG 219

  Fly   265 MFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRLSGGAELVEQLL 329
            ||..|||....||||||:||||||..|.:|:.|||.||||....|||||:||:..||..||||||
Human   220 MFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLL 284

  Fly   330 ANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKGESATVAS 394
            .:.||.....|::||..:|.|.:|.::||:|.::|||||||||||||||||||.||
Human   285 QDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVL--------- 340

  Fly   395 PAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARAAASG 459
             .:|..|.||   ||..|||||.|||||.|||||||:|:.|||||:|||||||||::|.|..|..
Human   341 -LQTPAQAGE---EPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALE 401

  Fly   460 LKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHCEEHQIPLVVVL 524
            .|:||::.:|.||||.|.|.|:|||:::.|||||:|||..||.|||||.|||:|||..||||.::
Human   402 EKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAII 466

  Fly   525 GDAELAQGLVKLREVTTREETNVKLEDLAAEIRRR 559
            |:.||..|::|||.||:|||.:|:.|||..||:||
Human   467 GEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRR 501

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.