DRSC/TRiP Functional Genomics Resources

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Protein Alignment HisRS and Eif2ak4

DIOPT Version :10

Sequence 1:NP_573305.2 Gene:HisRS / 32841 FlyBaseID:FBgn0027087 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_038747.2 Gene:Eif2ak4 / 27103 MGIID:1353427 Length:1648 Species:Mus musculus


Alignment Length:573 Identity:142/573 - (24%)
Similarity:239/573 - (41%) Gaps:128/573 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 PAQRQQQQQ--------PQKQQQAQVQQQQHEQLHQIDEEVARLL-----------ALKATLGGD 91
            ||:|....:        |.:.:::::.:..|..|..||.:..|.:           |:..|...|
Mouse   985 PAKRPTAMELLKSELLPPPQMEESELHEVLHHTLANIDGKAYRTMMSQIFCQHISPAIDYTYDSD 1049

  Fly    92 AAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGGEAIDTPVFELKEVLTGKYGEDS 156
            ....|  |.::|.|           ::|.|.:.||:||||||...:.||:...:          :
Mouse  1050 ILKGN--FLIRTAK-----------IQQLVCETIVRVFKRHGAVQLCTPLLLPR----------N 1091

  Fly   157 KLIYD------LKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAKVYR-----RDNPAMTK 210
            :.||:      ..|..|.::.:.:||.||.|||:|.|.|.::|||.|.:|:|     |.:|    
Mouse  1092 RQIYEHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHP---- 1152

  Fly   211 GRYREFYQCDFDI-AGTYDPMLPDAECVKIVSEILD---TLDIGDYVIKLNHRQLLDGMFQACGV 271
               :|..:|.||| ..|.:..||.||.:..:.||:.   .|...:|.|.|||..||..:...||:
Mouse  1153 ---KELLECAFDIVTSTTNSSLPTAETIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGI 1214

  Fly   272 PADSFRTIC-----SAVDKLDKSPWADVRKEMVDEK----GLDEAAADRIGEYVRLSGGAELVEQ 327
            |.|....:.     :..:||       .|:| |:.|    .|...:..|:.:::...|..:    
Mouse  1215 PEDKLSQVYVILYDAVTEKL-------TRRE-VEAKFCNLSLSSNSLCRLYKFIEQKGDLQ---- 1267

  Fly   328 LLANEKLKAVPNAVKGLEGMKQLLKYC-----SIFGLDKR------VSFDLSLARGLDYYTGVIY 381
                :....:.:.:|...|:.||:||.     .:.||.|:      ||.:|.|...:..:||:|:
Mouse  1268 ----DLTPTINSLIKQKTGVAQLVKYSLKDLEDVVGLLKKLGVKLQVSINLGLVYKVQQHTGIIF 1328

  Fly   382 EGVLKGESATVASPAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMF-DPR--GKAVPCVGVSIG 443
            :.:...:......|.                 .:|.|||||.|:..| .|:  |.....|||||.
Mouse  1329 QFLAFSKRRQRVVPE-----------------ILAAGGRYDLLIPKFRGPQTVGPVPTAVGVSIA 1376

  Fly   444 VERIFSVLEARAAASGLK--LRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKL 506
            :::||      ||...::  :..|..::.|.|..:....:.:.:...||.||:.||..|..:...
Mouse  1377 IDKIF------AAVLNMEEPVTVSSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQ 1435

  Fly   507 LVQLQHCEEHQIPLVVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRR 559
            ....::|..|:|..|.::.|.|.:...||..|...:.|..|...||...:.::
Mouse  1436 EELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLESDLVDHVMQK 1488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisRSNP_573305.2 S15_NS1_EPRS_RNA-bind 6..92 CDD:469733 11/64 (17%)
PLN02972 <102..559 CDD:215525 128/496 (26%)
Eif2ak4NP_038747.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
RWD_GCN2 20..138 CDD:467659
PK_eIF2AK_GCN2_rpt1 299..537 CDD:270914
STKc_EIF2AK4_GCN2_rpt2 582..998 CDD:270948 3/12 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 661..784
Histidyl-tRNA synthetase-like 1021..1492 136/537 (25%)
PLN02972 <1070..1490 CDD:215525 124/475 (26%)
HGTP_anticodon 1396..1640 CDD:469699 22/93 (24%)
Blue background indicates that the domain is not in the aligned region.

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