DRSC/TRiP Functional Genomics Resources

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Protein Alignment HisRS and Eif2ak4

DIOPT Version :9

Sequence 1:NP_573305.2 Gene:HisRS / 32841 FlyBaseID:FBgn0027087 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_038747.2 Gene:Eif2ak4 / 27103 MGIID:1353427 Length:1648 Species:Mus musculus


Alignment Length:573 Identity:142/573 - (24%)
Similarity:239/573 - (41%) Gaps:128/573 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 PAQRQQQQQ--------PQKQQQAQVQQQQHEQLHQIDEEVARLL-----------ALKATLGGD 91
            ||:|....:        |.:.:::::.:..|..|..||.:..|.:           |:..|...|
Mouse   985 PAKRPTAMELLKSELLPPPQMEESELHEVLHHTLANIDGKAYRTMMSQIFCQHISPAIDYTYDSD 1049

  Fly    92 AAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGGEAIDTPVFELKEVLTGKYGEDS 156
            ....|  |.::|.|           ::|.|.:.||:||||||...:.||:...:          :
Mouse  1050 ILKGN--FLIRTAK-----------IQQLVCETIVRVFKRHGAVQLCTPLLLPR----------N 1091

  Fly   157 KLIYD------LKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAKVYR-----RDNPAMTK 210
            :.||:      ..|..|.::.:.:||.||.|||:|.|.|.::|||.|.:|:|     |.:|    
Mouse  1092 RQIYEHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHP---- 1152

  Fly   211 GRYREFYQCDFDI-AGTYDPMLPDAECVKIVSEILD---TLDIGDYVIKLNHRQLLDGMFQACGV 271
               :|..:|.||| ..|.:..||.||.:..:.||:.   .|...:|.|.|||..||..:...||:
Mouse  1153 ---KELLECAFDIVTSTTNSSLPTAETIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGI 1214

  Fly   272 PADSFRTIC-----SAVDKLDKSPWADVRKEMVDEK----GLDEAAADRIGEYVRLSGGAELVEQ 327
            |.|....:.     :..:||       .|:| |:.|    .|...:..|:.:::...|..:    
Mouse  1215 PEDKLSQVYVILYDAVTEKL-------TRRE-VEAKFCNLSLSSNSLCRLYKFIEQKGDLQ---- 1267

  Fly   328 LLANEKLKAVPNAVKGLEGMKQLLKYC-----SIFGLDKR------VSFDLSLARGLDYYTGVIY 381
                :....:.:.:|...|:.||:||.     .:.||.|:      ||.:|.|...:..:||:|:
Mouse  1268 ----DLTPTINSLIKQKTGVAQLVKYSLKDLEDVVGLLKKLGVKLQVSINLGLVYKVQQHTGIIF 1328

  Fly   382 EGVLKGESATVASPAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMF-DPR--GKAVPCVGVSIG 443
            :.:...:......|.                 .:|.|||||.|:..| .|:  |.....|||||.
Mouse  1329 QFLAFSKRRQRVVPE-----------------ILAAGGRYDLLIPKFRGPQTVGPVPTAVGVSIA 1376

  Fly   444 VERIFSVLEARAAASGLK--LRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKL 506
            :::||      ||...::  :..|..::.|.|..:....:.:.:...||.||:.||..|..:...
Mouse  1377 IDKIF------AAVLNMEEPVTVSSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQ 1435

  Fly   507 LVQLQHCEEHQIPLVVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRR 559
            ....::|..|:|..|.::.|.|.:...||..|...:.|..|...||...:.::
Mouse  1436 EELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLESDLVDHVMQK 1488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisRSNP_573305.2 S15_NS1_EPRS_RNA-bind 6..92 CDD:294248 11/64 (17%)
HisS 98..561 CDD:223202 129/502 (26%)
HisRS-like_core 114..452 CDD:238396 101/375 (27%)
HisRS_anticodon 467..557 CDD:238436 22/89 (25%)
Eif2ak4NP_038747.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
RWD 26..137 CDD:214735
S_TKc 290..538 CDD:214567
PK_eIF2AK_GCN2_rpt1 299..537 CDD:270914
STKc_EIF2AK4_GCN2_rpt2 582..998 CDD:270948 3/12 (25%)
S_TKc 589..1000 CDD:214567 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 661..784
Histidyl-tRNA synthetase-like 1021..1492 136/537 (25%)
HisS 1049..1485 CDD:223202 131/504 (26%)
class_II_aaRS-like_core 1060..1384 CDD:294192 103/390 (26%)
HGTP_anticodon 1394..1640 CDD:294191 23/95 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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