DRSC/TRiP Functional Genomics Resources

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Protein Alignment HisRS and EIF2AK1

DIOPT Version :10

Sequence 1:NP_573305.2 Gene:HisRS / 32841 FlyBaseID:FBgn0027087 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_055228.2 Gene:EIF2AK1 / 27102 HGNCID:24921 Length:630 Species:Homo sapiens


Alignment Length:444 Identity:80/444 - (18%)
Similarity:142/444 - (31%) Gaps:146/444 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 AIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNKISSIKRY-HIAK 199
            |||.|.          .|.|.:  ||..|...||..::..|..|...:...|::..:... |::.
Human    26 AIDFPA----------EGPDPE--YDESDVPAEIQVLKEPLQQPTFPFAVANQLLLVSLLEHLSH 78

  Fly   200 VYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYVIKLNHRQLLDG 264
            |: ..||..::..::...|....:.     :|....|....|.           ::|:|.:.:..
Human    79 VH-EPNPLRSRQVFKLLCQTFIKMG-----LLSSFTCSDEFSS-----------LRLHHNRAITH 126

  Fly   265 MFQACGVPADSFRTICSAVDKLDKSPWAD---VRKEMVDEKGLDEAAADRIGEYVRLSGGAELVE 326
            :.:             ||.:::.:.|..|   ::|....|..|:...:..:.|:..|:       
Human   127 LMR-------------SAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELA------- 171

  Fly   327 QLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSF----DLSLARGLD------YYTGVIY 381
             :|.......|......|:|....:|...|.|..|.|..    ::.:..||.      |:|..|.
Human   172 -ILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIE 235

  Fly   382 E-------------------------------GVLKGESAT----VASPAKTSQQN-GEQANEPA 410
            .                               ||...||::    .|.|....::. ||...|..
Human   236 HVHVIQPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ 300

  Fly   411 TVGSVAGGGRY-DNLVGMFDPRGKAVPCVGVSIGVERIFSVLEARAAASGLKLRTSDVEVYVASA 474
            ...||    :| .|||                        :.|:....|.|:|:.:.:....||:
Human   301 NNKSV----KYTTNLV------------------------IRESGELESTLELQENGLAGLSASS 337

  Fly   475 HKGLHEQRLKVL--NLLWDAGVKAEHSYKLNPKLL------------VQLQHCE 514
               :.||:|.:.  :.|.::....|.|.:.|...|            :|:|.||
Human   338 ---IVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCE 388

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisRSNP_573305.2 S15_NS1_EPRS_RNA-bind 6..92 CDD:469733
PLN02972 <102..559 CDD:215525 80/444 (18%)
EIF2AK1NP_055228.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 7/25 (28%)
SIFI-degron. /evidence=ECO:0000269|PubMed:38297121 85..104 1/23 (4%)
STKc_EIF2AK1_HRI 160..581 CDD:270951 49/268 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..301 9/41 (22%)
HRM 1 410..415
HRM 2 552..557
Blue background indicates that the domain is not in the aligned region.

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