DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HisRS and AgaP_AGAP012368

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_320188.4	Gene:	AgaP_AGAP012368 / 1280343	VectorBaseID:	AGAP012368	Length:	1484	Species:	Anopheles gambiae

Alignment Length:	475	Identity:	111/475 - (23%)
Similarity:	191/475 - (40%)	Gaps:	134/475 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 KIVQVFKRHGGEAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNK 188
            |:|.:|::||...:.||   |....|.::...|..: .|....|.::::..||.||..|::|:|.
Mosquito   883 KLVALFRKHGAIEVVTP---LLTPYTKQHAARSNTV-KLMTHSGSVVTLPDDLRVPFLRHIALNG 943

  Fly   189 ISSIKRYHIAKVYRRD-----NPAMTKGRYREFYQCDFDI-AGTYDPMLPDAECVKIVSEILDTL 247
            |..|:||.|.:|||..     :|       ::.|:|.||| ..:...::.|||.:.|.::::..|
Mosquito   944 IKHIRRYSIGRVYREKKVFNFHP-------KQVYECAFDIVTPSRGHLITDAELLAIATDVMREL 1001

  Fly   248 DI---GDYVIKLNHRQLLDGMFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEK------- 302
            ::   .:...:|||..||..:...|.||.|.:|.:...|            .|.:|||
Mosquito  1002 NLLQGRNVFFRLNHIGLLRAILMHCNVPMDKYRELFEMV------------AEFLDEKISKFQLS 1054

  Fly   303 ----GLDEAAADRIG------------EYVRLSGGAELVEQLL--ANEKLKAVPNAVKGLEGMKQ 349
                .|...:|.:|.            ..|.|.||: :::.::  ..|.......||:.||.:..
Mosquito  1055 SLINSLIGGSAAKINVSFLCDALQLELSSVGLLGGS-ILKSIIRGKGEAASLAKVAVRELETVVT 1118

  Fly   350 LLKYCSIFGLDKRVSFDLSLARGL--DYYT----GVIYEGVLKGESATVASPAKTSQQNGEQANE 408
            |.:       :..|...|::..||  :|..    |::::  |.||       .|..::|
Mosquito  1119 LAQ-------NMGVQCPLNVCPGLPVNYERAKTGGIVWQ--LLGE-------LKPKRKN------ 1161

  Fly   409 PATVGSVAGGGRYDNLVGMFDP----RGKAVPCVGVSIGVERIF---SVLEARAAASGLKLRTSD 466
            |.|  ::|.|||||..:..|..    .|..||.|.:| |....|   .::.|.|..:|.:    .
Mosquito  1162 PLT--TIAVGGRYDGKLAEFQKSGINNGLQVPKVDLS-GAGFSFLLDKLVNAIAPTAGYE----P 1219

  Fly   467 VEVYV-ASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHC-------------EEHQ 517
            :||.: .:..:...::..:.|..||...:|.                |             :|..
Mosquito  1220 IEVMICVTGSRPQPKEVAQTLRPLWSNSIKT----------------CVVETSAGAVDDLGKEAG 1268

  Fly   518 IPLVVVLGDAELAQGLVKLR 537
            ..:||:|||.    |.:::|
Mosquito  1269 ATVVVLLGDG----GEMRVR 1284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:294248
		HisS	98..561	CDD:223202	111/475 (23%)
		HisRS-like_core	114..452	CDD:238396	93/374 (25%)
		HisRS_anticodon	467..557	CDD:238436	15/85 (18%)
AgaP_AGAP012368	XP_320188.4	RWD	11..123	CDD:283440
		DUF755	125..205	CDD:253225
		PKc_like	244..450	CDD:304357
		PKc_like	<667..815	CDD:304357
		HisS	873..1309	CDD:223202	111/475 (23%)
		class_II_aaRS-like_core	876..1211	CDD:294192	93/376 (25%)
		DUF2779	<1435..1459	CDD:287984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810