Protein Alignment HisRS and HisRS

DIOPT Version :10

• Sequence 1: NP_573305.2
• Gene: HisRS / 32841
• FlyBaseID: FBgn0027087
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_003437081.2
• Gene: HisRS / 1272323
• VectorBaseID: AGAMI1_011150
• Length: 548
• Species: Anopheles gambiae
• Alignment Length: 571
• Identity: 350/571 - (61%)
• Similarity: 424/571 - (74%)
• Gaps: 48/571 - (8%)

  Fly    18 LVRQ-LKAAKESKEKTAPSGGGRVSSSGVPAQRQQQQQPQKQQQAQVQQQQHEQLHQIDEEVARL 81
            |.|| |..|..|..:.:.:..|.|.:|.:.|.|..::..:            ::|.||:|||.:|
Mosquito     2 LARQLLLGAGCSLRRFSSASRGAVVASTMQAIRAGEEDVR------------QRLAQINEEVQKL 54

  Fly    82 LALKATL---------GGDAA--------------PTNQKFTLKTPKGTRDYGPQQMTLRQGVLD 123
            ||||..|         .|:.|              |.|:..:||||||||||||:.|.|||.|||
Mosquito    55 LALKEQLKQLTVDDDGSGETAAATPAPGKPAAASEPGNRNLSLKTPKGTRDYGPEAMALRQRVLD 119

  Fly   124 KIVQVFKRHGGEAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNK 188
            ::|:||:|||.|.||||||||||||||||||||||||||||||||||::|||||||.|||:.|..
Mosquito   120 QVVRVFRRHGAETIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILALRYDLTVPFARYVGMGN 184

  Fly   189 ISSIKRYHIAKVYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYV 253
            :.:|||||||||||||||.:|:||||||||||||||||||||||||||||:|.|||..:.:||:|
Mosquito   185 VFNIKRYHIAKVYRRDNPQITRGRYREFYQCDFDIAGTYDPMLPDAECVKVVCEILAEVGVGDFV 249

  Fly   254 IKLNHRQLLDGMFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRL 318
            :|||||:||||:|:|||||||.|||.||:||||||:||.:||:|||:||||.|.|..|||::|.|
Mosquito   250 VKLNHRKLLDGIFEACGVPADKFRTACSSVDKLDKTPWEEVRREMVEEKGLSEEAVGRIGQFVTL 314

  Fly   319 SGGAELVEQLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEG 383
            .||.||:|:|.|:|.|:.:..|::|||.|:.||:||.||.:..|||||||||||||||||||||.
Mosquito   315 HGGTELIERLAADETLRGIKVAMEGLEDMRLLLQYCEIFQVADRVSFDLSLARGLDYYTGVIYEA 379

  Fly   384 VLKGESATVASPAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIF 448
            ||.|....         ..|..|:|..||||||||||||||||||:|:.|.||||||||||||:|
Mosquito   380 VLLGGGGA---------GGGSSADEEITVGSVAGGGRYDNLVGMFNPKRKQVPCVGVSIGVERLF 435

  Fly   449 SVLEARAAASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHC 513
            |:|||||   |.|.||::.||||||||||||.:||::||.||.||:|||||||||||||.|||||
Mosquito   436 SILEARA---GGKTRTNETEVYVASAHKGLHLKRLEILNKLWSAGLKAEHSYKLNPKLLAQLQHC 497

  Fly   514 EEHQIPLVVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRRQQASA 564
            ||:|||..|:|||.||::|:|||||:.||:|..|.|:....|:|||..::|
Mosquito   498 EEYQIPYAVILGDGELSRGVVKLREIATRKEEEVALDTFIEELRRRLLSAA 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:469733	24/83 (29%)
		PLN02972	<102..559	CDD:215525	319/456 (70%)
HisRS	XP_003437081.2	None