DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HisRS and AgaP_AGAP000735

DIOPT Version :9

Sequence 1:	NP_573305.2	Gene:	HisRS / 32841	FlyBaseID:	FBgn0027087	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	XP_003437081.1	Gene:	AgaP_AGAP000735 / 1272323	VectorBaseID:	AGAP000735	Length:	548	Species:	Anopheles gambiae

Alignment Length:	571	Identity:	350/571 - (61%)
Similarity:	424/571 - (74%)	Gaps:	48/571 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LVRQ-LKAAKESKEKTAPSGGGRVSSSGVPAQRQQQQQPQKQQQAQVQQQQHEQLHQIDEEVARL 81
            |.|| |..|..|..:.:.:..|.|..|.:.|.|..::..:            ::|.||:|||.:|
Mosquito     2 LARQLLLGAGCSLRRFSSASRGAVVVSTMQAIRAGEEDVR------------QRLAQINEEVQKL 54

  Fly    82 LALKATL---------GGDAA--------------PTNQKFTLKTPKGTRDYGPQQMTLRQGVLD 123
            ||||..|         .|:.|              |.|:..:||||||||||||:.|.|||.|||
Mosquito    55 LALKEQLKQLTVDDDGSGETAAATPAPGKPAAASEPGNRNLSLKTPKGTRDYGPEAMALRQRVLD 119

  Fly   124 KIVQVFKRHGGEAIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILSMRYDLTVPLARYLAMNK 188
            ::|:||:|||.|.||||||||||||||||||||||||||||||||||::|||||||.|||:.|..
Mosquito   120 QVVRVFRRHGAETIDTPVFELKEVLTGKYGEDSKLIYDLKDQGGEILALRYDLTVPFARYVGMGN 184

  Fly   189 ISSIKRYHIAKVYRRDNPAMTKGRYREFYQCDFDIAGTYDPMLPDAECVKIVSEILDTLDIGDYV 253
            :.:|||||||||||||||.:|:||||||||||||||||||||||||||||:|.|||..:.:||:|
Mosquito   185 VFNIKRYHIAKVYRRDNPQITRGRYREFYQCDFDIAGTYDPMLPDAECVKVVCEILAEVGVGDFV 249

  Fly   254 IKLNHRQLLDGMFQACGVPADSFRTICSAVDKLDKSPWADVRKEMVDEKGLDEAAADRIGEYVRL 318
            :|||||:||||:|:|||||||.|||.||:||||||:||.:||:|||:||||.|.|..|||::|.|
Mosquito   250 VKLNHRKLLDGIFEACGVPADKFRTACSSVDKLDKTPWEEVRREMVEEKGLSEEAVGRIGQFVTL 314

  Fly   319 SGGAELVEQLLANEKLKAVPNAVKGLEGMKQLLKYCSIFGLDKRVSFDLSLARGLDYYTGVIYEG 383
            .||.||:|:|.|:|.|:::..|::|||.|:.||:||.||.:..|||||||||||||||||||||.
Mosquito   315 HGGTELIERLAADETLRSIKVAMEGLEDMRLLLQYCEIFQVADRVSFDLSLARGLDYYTGVIYEA 379

  Fly   384 VLKGESATVASPAKTSQQNGEQANEPATVGSVAGGGRYDNLVGMFDPRGKAVPCVGVSIGVERIF 448
            ||.|....         ..|..|:|..||||||||||||||||||:|:.|.||||||||||||:|
Mosquito   380 VLLGGGGA---------GGGSSADEEITVGSVAGGGRYDNLVGMFNPKRKQVPCVGVSIGVERLF 435

  Fly   449 SVLEARAAASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKLLVQLQHC 513
            |:|||||   |.|.||::.||||||||||||.:||::||.||.||:|||||||||||||.|||||
Mosquito   436 SILEARA---GGKTRTNETEVYVASAHKGLHLKRLEILNKLWSAGLKAEHSYKLNPKLLAQLQHC 497

  Fly   514 EEHQIPLVVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRRQQASA 564
            ||:|||..|:|||.||::|:|||||:.||:|..|.|:....|:|||..::|
Mosquito   498 EEYQIPYAVILGDGELSRGVVKLREIATRKEEEVALDTFIEELRRRLLSAA 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HisRS	NP_573305.2	S15_NS1_EPRS_RNA-bind	6..92	CDD:294248	24/83 (29%)
		HisS	98..561	CDD:223202	322/462 (70%)
		HisRS-like_core	114..452	CDD:238396	237/337 (70%)
		HisRS_anticodon	467..557	CDD:238436	61/89 (69%)
AgaP_AGAP000735	XP_003437081.1	S15_NS1_EPRS_RNA-bind	<45..79	CDD:294248	13/33 (39%)
		HisS	94..544	CDD:223202	321/461 (70%)
		HisRS-like_core	111..439	CDD:238396	237/336 (71%)
		HisRS_anticodon	450..541	CDD:238436	61/90 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	440	1.000	Domainoid score	I1703
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1592
Inparanoid	1	1.050	673	1.000	Inparanoid score	I1998
OMA	1	1.010	-	-		QHG55859
OrthoDB	1	1.010	-	-		D1065556at2759
OrthoFinder	1	1.000	-	-		FOG0001634
OrthoInspector	1	1.000	-	-		oto108845
Panther	1	1.100	-	-	LDO	PTHR11476
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1525
TreeFam	0	0.000	Not matched by this tool.
	11	11.080