DRSC/TRiP Functional Genomics Resources

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Protein Alignment HisRS and Eif2ak4

DIOPT Version :10

Sequence 1:NP_573305.2 Gene:HisRS / 32841 FlyBaseID:FBgn0027087 Length:564 Species:Drosophila melanogaster
Sequence 2:NP_001099214.2 Gene:Eif2ak4 / 114859 RGDID:1311439 Length:1649 Species:Rattus norvegicus


Alignment Length:573 Identity:141/573 - (24%)
Similarity:236/573 - (41%) Gaps:128/573 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 PAQRQQQQQ--------PQKQQQAQVQQQQHEQLHQIDEEVARLL-----------ALKATLGGD 91
            ||:|....:        |.:.:::::.:..|..|...|.:..|.:           |:..|...|
  Rat   986 PAKRPTAMELLKSELLPPPQMEESELHEVLHHTLANTDGKAYRTMMSQLFCQHSSPAIDYTYDSD 1050

  Fly    92 AAPTNQKFTLKTPKGTRDYGPQQMTLRQGVLDKIVQVFKRHGGEAIDTPVFELKEVLTGKYGEDS 156
            ....|  |.::|.|           ::|.|.:.||:||||||...:.||:...:          :
  Rat  1051 ILKGN--FLIRTAK-----------IQQLVCETIVRVFKRHGAVQLCTPLLLPR----------N 1092

  Fly   157 KLIYD------LKDQGGEILSMRYDLTVPLARYLAMNKISSIKRYHIAKVYR-----RDNPAMTK 210
            :.||:      ..|..|.::.:.:||.||.|||:|.|.|.::|||.|.:|:|     |.:|    
  Rat  1093 RQIYEHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHP---- 1153

  Fly   211 GRYREFYQCDFDI-AGTYDPMLPDAECVKIVSEILD---TLDIGDYVIKLNHRQLLDGMFQACGV 271
               :|..:|.||| ..|.:..||.||.:..:.|::.   .|...:|.|.|||..||..:...||:
  Rat  1154 ---KELLECAFDIVTSTANSSLPTAETIYTIYEVIQEFPALQERNYSIYLNHTMLLKAILLHCGI 1215

  Fly   272 PADSFRTIC-----SAVDKLDKSPWADVRKEMVDEK----GLDEAAADRIGEYVRLSGGAELVEQ 327
            |.|....:.     :..:||       .|:| |:.|    .|...:..|:.:::...|..:    
  Rat  1216 PEDKLSQVYVILYDAVTEKL-------TRRE-VEAKFCNLSLSSNSLCRLYKFIEQKGDLQ---- 1268

  Fly   328 LLANEKLKAVPNAVKGLEGMKQLLKYC-----SIFGLDKRVSFDLSLARGLDYYTGVIYEGVLKG 387
                :....:.:.:|...|:.||:||.     .:.||.|::...|.::..|    |::|      
  Rat  1269 ----DLTPTINSLIKQKTGIAQLVKYSLKDLEEVVGLLKKLGVKLQVSINL----GLVY------ 1319

  Fly   388 ESATVASPAKTSQQNG--------EQANEPATVGSVAGGGRYDNLVGMF-DPR--GKAVPCVGVS 441
                     |..|.||        .:..:......:|.|||||.|:..| .|:  |.....||||
  Rat  1320 ---------KVQQHNGIIFQFLAFSKRRQRVVPEILAAGGRYDLLIPKFRGPQALGPVPTAVGVS 1375

  Fly   442 IGVERIFSVLEARAAASGLKLRTSDVEVYVASAHKGLHEQRLKVLNLLWDAGVKAEHSYKLNPKL 506
            |.:::||    |.....|..:..|..::.|.||.:....:.:.:...||.||:.||..|..:...
  Rat  1376 IAIDKIF----AAVLNMGEPVTVSSCDLLVVSAGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQ 1436

  Fly   507 LVQLQHCEEHQIPLVVVLGDAELAQGLVKLREVTTREETNVKLEDLAAEIRRR 559
            ....::|..|:|..|.::.|.|.:...||..|...:.|..|...||...:.::
  Rat  1437 EELQEYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLESDLVDHVMQK 1489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HisRSNP_573305.2 S15_NS1_EPRS_RNA-bind 6..92 CDD:469733 10/64 (16%)
PLN02972 <102..559 CDD:215525 128/496 (26%)
Eif2ak4NP_001099214.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
RWD_GCN2 20..138 CDD:467659
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..260
PK_eIF2AK_GCN2_rpt1 299..538 CDD:270914
STKc_EIF2AK4_GCN2_rpt2 583..999 CDD:270948 3/12 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..785
Histidyl-tRNA synthetase-like. /evidence=ECO:0000250|UniProtKB:Q9QZ05 1022..1493 135/537 (25%)
PLN02972 <1071..1491 CDD:215525 124/475 (26%)
HGTP_anticodon 1397..1641 CDD:469699 23/93 (25%)
Blue background indicates that the domain is not in the aligned region.

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