Protein Alignment RhoGAPp190 and Arhgap5

DIOPT Version :10

• Sequence 1: NP_001259658.1
• Gene: RhoGAPp190 / 32743
• FlyBaseID: FBgn0026375
• Length: 1621
• Species: Drosophila melanogaster
• Sequence 2: NP_001386329.1
• Gene: Arhgap5 / 299012
• RGDID: 1308507
• Length: 1503
• Species: Rattus norvegicus
• Alignment Length: 1682
• Identity: 483/1682 - (28%)
• Similarity: 794/1682 - (47%)
• Gaps: 317/1682 - (18%)

  Fly     4 FNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGRIVNNDHFLYWGD 68
            :.:||:||||||||:|..|||||||||||:|..||:|:.:|.||||..||.||:|||||||||||
  Rat    13 YTVSVVGLSGTEKDKGNCGVGKSCLCNRFVRSKADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGD 77

  Fly    69 VRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGKMDPYSKRCTATKVFSAEKLMYICKNQLGIEK 133
            :.:..|:|||.:.::||||||:||.||...:...:.||.||..|:|:.|||||||||.:|||:|:
  Rat    78 ITQNGEDGVECKIHVIEQTEFIDDQTFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQ 142

  Fly   134 EYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDAYEL 198
            ::|||.||:|:|::|||::..|||...||..:.|::||.|:...:.|:|||:::..||.|:..:.
  Rat   143 DFEQKQMPEGKLNVDGFLLCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDH 207

  Fly   199 YVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRKELL 263
            |:||.:..:..   |..:.::||||..::||:..|..|.||:||.:.:.|||.|.::.|::::|:
  Rat   208 YLREVQAFASN---KKNLLVVETSARFNVNIETCFTALVQMLDKTRGKPKIIPYLDAYKTQRQLV 269

  Fly   264 DTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDHLNK 328
            .|.::...:|::. :.|||..|...|..|..:.::.|::|:.|....:..|.:|:::|:.:|:.|
  Rat   270 VTATDKFEKLVQT-VRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRK 333

  Fly   329 KLHQYLDKFALALEYLLPD---IGALNISDDDAWECARNYLQNHIEFEQYFFECPQASWTELVDM 390
            :..:|:.....|...||||   |..||      |..|...::...:|:..|....:..|.|...:
  Rat   334 RREEYISTLPRAFNTLLPDLEEIEHLN------WLEALKLMEKRADFQLCFVVLEKTPWDETDHI 392

  Fly   391 DEAEDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIGWKQQFKMLLEESGFVTPGKQLSEVRVL 455
            |:..|. |||||:|.|.|||.|::|::..:..:|::|..|::||..||:..|::||:...||...
  Rat   393 DKINDR-RIPFDLLSTLEAEKVYQNHVQHLISEKRRIEMKEKFKKTLEKIQFISPGQPWEEVMCF 456

  Fly   456 FMGRECFEALSEHDCQQIYDIHQDDIIEKSKQNFVELLLEHAQYFLQFKNVDNITQEDVRQITDV 520
            .|..|.|:.::|.|.:::|..||.:|:||:|:.|.|:|.||::.|.........:.:.:.:|..|
  Rat   457 VMEDEAFKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNATPSSDKMSEIHTV 521

  Fly   521 IQEDSRYKMLDRLDQERRLMLVQHLRFIHCPIRDHCPFFYNCVDSLIEEVLSDKSASNHKTPSGG 585
            :.|:.|||.|.:|..:|..:|::|:.|::.|.::.|.....|.|..:|.:|::...  |...:..
  Rat   522 LSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQYCTDIKVENLLANSLL--HSDHNRS 584

  Fly   586 GWKSSGSGSDRTLNLLIVGSEHLASDLLNDIRICTGSKGEYIYENQTYYLNYRIANGD------- 643
            ......:..|: :||.|:|.:.||.:|.|:|| ...:..||..:.:.|.|:.|..:..
  Rat   585 RLYHDSTNIDK-VNLFILGKDGLAQELANEIR-TQSTDDEYALDGKIYELDLRPVDAKSPYILSQ 647

  Fly   644 --MEAFKAIDVYSSGLICVYSNQQSFETLKDNLE--RTLLCNLELEDKFENLPIVLVYQPQ-DLK 703
              ..|||     ..|..||:::.:|...:.:.:.  ||....:..:....|||..|:...| |..
  Rat   648 LWTAAFK-----PHGCFCVFNSIESLSFIGEFIGKIRTEASQIRKDKYMANLPFTLILANQRDSI 707

  Fly   704 ENEVEYLRNEGMRLSEMLHCDFID------HTQNHQKYVYDILNIVILSLKLTEMKSYEPYPSN- 761
            ...:..||::|.:|:..|.|.|:|      ..:.::..:...|..|:.|:| ..:....|.|.|
  Rat   708 SKNLPILRHQGQQLANKLQCPFVDVPAGTYPRKFNESQIKQALRGVLESVK-HNLDVVSPVPINK 771

  Fly   762 ---HTDLRILCCIFCGDQYDIENIVQPLVEE---STLVKANEHSIIVDVFIGDAKRRVEFILSSY 820
               ..||||:.|..|||.:.::.|:.|.::.   |.......:|:::|..||:.:||::..:.||
  Rat   772 DVSEADLRIVMCAMCGDPFSVDIILSPFLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSY 836

  Fly   821 HGTSQYR-DELIHGYIYFYSTKRRSSLANL-SILAAQNANIPLQIIAVTESGGVNAFFNSDICQF 883
            |.:...| |||:||||..||.||::|:..| :.|:.....||:|::|||:|..  .||.::..:.
  Rat   837 HSSIGVRKDELVHGYILVYSAKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQA--DFFENEAIKE 899

  Fly   884 LITEGNAVADRFKGSFMT-FSADQY-----VKFAFYNPFL--KTAWDNKYEVEN----LHVEESI 936
            |:|||..:|......|.. :|..||     |...|::..|  |...:|.|..:|    .|..|.:
  Rat   900 LMTEGEHIATEITAKFTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDV 964

  Fly   937 TLDSGE-----GTLENSVNQMPRPPPRHESYMLSNTLGTDGSGSENYEMAPTRSLNSLNEERDIS 996
            .|.|..     ....:|.:....|||       .:.:|.|      .::.||.|     :.....
  Rat   965 FLPSPRDCFPYNNYPDSDDDTEAPPP-------YSPIGDD------VQLLPTPS-----DRSRYR 1011

  Fly   997 LDEIYDDNEKPKHL------HQRFQIFPPPTTPPEPAPPDHQLITCTYKSQFVSASESSLEEITS 1055
            ||  .:.||.|.|.      |:|....||| ..|:|..|
  Rat  1012 LD--LEGNEYPVHSTPNCHDHERNHKVPPP-IKPKPVVP-------------------------- 1047

  Fly  1056 DVSGSKDSLATHDAEWLEDKSDGRRNMNKNLIWNNFSGSTHAYTTGRRHIDSNLNKIRPKGPSQT 1120
                                   :.|:.|                    :|.||.|....|
  Rat  1048 -----------------------KTNVKK--------------------LDPNLLKTIEAG---- 1065

  Fly  1121 LKVGEAPSRNCPAMSSSTFTLPTQQPGKLNMKNFQLVSDAVAKMNFTGSGSGSGSGSGSGSTGLG 1185
              :|:.|.:       .|..:|...|..::
  Rat  1066 --IGKNPRK-------QTSRVPLAHPEDMD----------------------------------- 1086

  Fly  1186 LGLGSGSGCMGDSFLEPVDKDGKRY---DHAQLDGEDEDSEELAEYEQIYENEDCTESDSCASST 1247
                     ..|::.||:|...|:.   |...:..:|..:..:........|....|.:..:..|
  Rat  1087 ---------SSDNYAEPLDTIFKQKGYPDEIYVVPDDSQNRIIKIRNSFVNNTQGDEENGFSDRT 1142

  Fly  1248 -----ERRVRQQNAYYKASKKPVAAKKQKKKKVAIPVQTPRVPPFGSYVSPPEIPLHYQRMAVGG 1307
                 |||..:    ||...|.:.:|.:.                           :|:|.....
  Rat  1143 SKGHGERRPSK----YKYKSKTLFSKAKS---------------------------YYRRTHSDA 1176

  Fly  1308 SG----PGEKKKPEPCVPEFMKSDKSPEYSMVPELAGAGIFGAENLPEYNMNQAKCLKDFEKLEK 1368
            |.    |..|.|.:   .....|::.|..|.|....|    |.:| |....:|.   .|.:|::|
  Rat  1177 SDDEAFPTSKTKRK---GRHRGSEEDPLLSPVETWKG----GIDN-PAITSDQE---VDDKKIKK 1230

  Fly  1369 R--RIKEETARQRKLQEKEKEQEKKLKRKLKQNAKGLVESAEAQFGKLMITSEQGEIPIFLNKCV 1431
            :  ::||:    :|.::|.|......:|..:.|..|:....       ::|:|: .||:|:.|||
  Rat  1231 KPHKVKED----KKQKKKTKTFNPPTRRNWESNYFGMPLQD-------LVTAEK-PIPLFVEKCV 1283

  Fly  1432 EFIEKEGLDSEGIYRVPGSRAHVDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFSKRLPPLFS 1496
            ||||..||.:||:|||.|::...|.:.::|::|.|..:.::::.|||||.|||.||:....||..
  Rat  1284 EFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINLASMEVTVNAVAGALKAFFADLPDPLIP 1348

  Fly  1497 KDIIKELEEIAGSRGVGNSKLNVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNS 1561
            ..:..||.|.|        |:     .|::.||.|||.:::|..|:|:.:.:|:..|...||..:
  Rat  1349 YSLHPELLEAA--------KI-----PDKTERLHALKEIVKKFHPVNYDVFRYVITHLNRVSQQN 1400

  Fly  1562 KLNSMDSKNLAICWWPTLIPIDFTDMGHFEQLRPYL------EDIVQTMIDQFPYLF 1612
            |:|.|.:.||:||:||||:..||.:       |.:|      :.:|:|.|.|..:.|
  Rat  1401 KINLMTADNLSICFWPTLMRPDFEN-------REFLSTTKIHQSVVETFIQQCQFFF 1450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAPp190	NP_001259658.1	P-loop containing Nucleoside Triphosphate Hydrolases	<148..238	CDD:476819	31/89 (35%)
		RhoGAP-FF1	254..333	CDD:465153	18/78 (23%)
		pseudoGTPaseD_p190RhoGAP	598..748	CDD:412064	41/167 (25%)
		RhoGAP_p190	1411..1611	CDD:239838	73/205 (36%)
Arhgap5	NP_001386329.1	P-loop containing Nucleoside Triphosphate Hydrolases	31..246	CDD:476819	107/217 (49%)
		RhoGAP-FF1	260..338	CDD:465153	18/78 (23%)
		FF	368..420	CDD:128718	18/52 (35%)
		FF	428..481	CDD:128718	19/52 (37%)
		FF	484..533	CDD:128718	16/48 (33%)
		RhoGAP_pG1_pG2	556..1265	CDD:466111	194/913 (21%)
		RhoGAP_p190	1261..1445	CDD:239838	73/211 (35%)