Protein Alignment RhoGAPp190 and RhoGAPp190

DIOPT Version :10

• Sequence 1: NP_001259658.1
• Gene: RhoGAPp190 / 32743
• FlyBaseID: FBgn0026375
• Length: 1621
• Species: Drosophila melanogaster
• Sequence 2: XP_061498709.1
• Gene: RhoGAPp190 / 1277386
• VectorBaseID: AGAMI1_009202
• Length: 1781
• Species: Anopheles gambiae
• Alignment Length: 1859
• Identity: 872/1859 - (46%)
• Similarity: 1171/1859 - (62%)
• Gaps: 316/1859 - (16%)

  Fly     1 MRQFNISVIGLSGTEKDRGQVGVGKSCLCNRFMRPMADDYFIDHISVLSQSDFSGRIVNNDHFLY 65
            |:|.|:||:||||.|||:||:|||||||||||:||..|||.|||||||||||||||:||||||||
Mosquito     1 MKQINVSVVGLSGVEKDKGQLGVGKSCLCNRFVRPKTDDYAIDHISVLSQSDFSGRVVNNDHFLY 65

  Fly    66 WGDVRKTTEEGVEYQFNIIEQTEFMDDSTFQAFKVGKMDPYSKRCTATKVFSAEKLMYICKNQLG 130
            ||:||||:||||:|.|::||||||:||:|||.||||||:||.|||.|.::.|.|||.||||||||
Mosquito    66 WGEVRKTSEEGVDYNFSVIEQTEFVDDATFQPFKVGKMEPYIKRCAAIRMSSQEKLKYICKNQLG 130

  Fly   131 IEKEYEQKVMPDGRLSIDGFVVVFDVSPVPNRSVEKQVEFVQNVIATILKNKKPLVLVTTKNDDA 195
            ||.|||:.|:|:||..:||||.|||||.||||:||||||||..:|..|||.|||:||||||||||
Mosquito   131 IEHEYEEIVLPEGRFLVDGFVCVFDVSVVPNRTVEKQVEFVTQIINNILKVKKPVVLVTTKNDDA 195

  Fly   196 YELYVREAEKISQRKDYKSTVQLIETSAHESINIDLAFLLLAQMIDKVKNRVKIISYQESAKSRK 260
            .||||||||||..||:||..:.||||||||||||||||::|||||||.|.|.|:.||.|:||.|.
Mosquito   196 NELYVREAEKICSRKEYKGQILLIETSAHESINIDLAFVVLAQMIDKAKQRSKVPSYAEAAKQRN 260

  Fly   261 ELLDTRSEAVTRLIRNQITDYHVLWSQGSKMLSQYREWNEFLNIFGHEAGQKLFRRHMKKLRDDH 325
            :||:..:|.||||||.||||:..:||..||.||.:|||.:||.:||.||||::||||:||||:|:
Mosquito   261 DLLNASTEYVTRLIRTQITDHRSIWSSSSKKLSNHREWIDFLELFGQEAGQRIFRRHIKKLREDY 325

  Fly   326 LNKKLHQYLDKFALALEYLLPDIGALNISDD--DAWECARNYLQNHIEFEQYFFECPQ--ASWTE 386
            .:|||..|:|.||..|:.:||||.::|:..|  :.|...|:|.::||::|||||:..:  .||.|
Mosquito   326 QSKKLQSYMDSFACVLQEMLPDINSINLELDSFNDWASIRSYFRDHIDYEQYFFDAIERGGSWAE 390

  Fly   387 LVDMDEAEDEARIPFDVLETSEAETVFRNYLNSVQQDKKKIG----------------------- 428
            |.||.:.|||.|||||:|:|.||||||:|::|::||::|::.
Mosquito   391 LSDMSDMEDENRIPFDILDTPEAETVFKNHMNALQQEQKRLDTAVRARQFASVKFAQPTSFRPTN 455

  Fly   429 ------------WKQQFKMLLEESGFVTPGKQLSEVRVLFMGRECFEALSEHDCQQIYDIHQDDI 481
                        ||:|||.||||:|:|||||||||||||||||||||||||||||||||.||.::
Mosquito   456 DPPGGSVSPHYRWKKQFKKLLEETGYVTPGKQLSEVRVLFMGRECFEALSEHDCQQIYDNHQREL 520

  Fly   482 IEKSKQNFVELLLEHAQYFLQFKNVD---NITQEDVRQITDVIQEDSRYKMLDRLDQERRLMLVQ 543
            :|.:|.||.|||:|||..|..|||::   .|||.|:::||||:|||.|||:||||||:|::||.|
Mosquito   521 VETAKHNFQELLMEHADLFYHFKNIEPSGTITQNDIKEITDVLQEDLRYKLLDRLDQDRKVMLFQ 585

  Fly   544 HLRFIHCPIRDHCPFFYNCVDSLIEEVLSDKSASNHKTPSGGGWKSSGSGSDRTLNLLIVGSEHL 608
            ||.|:|||||:|||.|.||:|:|||.:|    .||...|:....:..|   ...|||:::|.:::
Mosquito   586 HLGFVHCPIREHCPAFPNCMDALIERIL----ISNQNLPNPRFAQKDG---QLQLNLIVIGLDYI 643

  Fly   609 ASDLLNDIRICTGSKGEYIYENQTYYLNYRIANGDMEAFKAIDVYSSGLICVYSNQQSFETLKDN 673
            |:|.::.|.......||||.:.|.|.||....|.|.::| :.::...||||.|||:|:|:.:.:.
Mosquito   644 ANDFIDKIHQNCNDNGEYIVDGQVYGLNIETINRDNDSF-SFELQCKGLICCYSNRQTFQYVYEV 707

  Fly   674 LERTLLCNLELEDKFENLPIVLVYQPQDLKENEVEYLRNEGMRLSEMLHCDFIDH-----TQNHQ 733
            |:|.|:.||:.:|...||.||.:...:: .::.:..|:.:|..|:|.|||.|||.     :|...
Mosquito   708 LDRLLVDNLDFKDSVNNLHIVFMSDEKN-SQSTLHQLQADGQSLAEKLHCVFIDENEFYISQQQT 771

  Fly   734 KYVYDILNIVILSLKLTEMK---SYEPYPSNHTDLRILCCIFCGDQYDIENIVQPLVEESTLVKA 795
            |::...||.||.|:...::|   :....|    ||||:..|||||.:.||||:..::.|.:.:.|
Mosquito   772 KFINTTLNSVIDSIPFEDLKYGLALHELP----DLRIIMSIFCGDPFSIENILSSMMLEQSCISA 832

  Fly   796 NEHSIIVDVFIGDAKRRVEFILSSYHGTSQYRDELIHGYIYFYSTKRRSSLANLSILAAQNANIP 860
            .|.:||.::|:||:|||||.|||||||.:.:||:||||:|..||:||::||:.||..:....|:|
Mosquito   833 GERNIIFEMFLGDSKRRVELILSSYHGANAFRDDLIHGFILLYSSKRKASLSTLSAFSLNIPNLP 897

  Fly   861 LQIIAVTESGGVNAFFNSDICQFLITEGNAVADRFKGSFMTFSADQ-YVKFAFYNPFLKTAWDNK 924
            :||:||:|.|||||||||::.|.||||||.:||:.:..|.|.|.|: .:|||.:.||||..||.|
Mosquito   898 MQIVAVSEQGGVNAFFNSELSQLLITEGNGIADKLRAHFATGSDDEGQLKFASFAPFLKEVWDKK 962

  Fly   925 YEVEN-LHVEESITLDSGEGTLENSVN-----QMPRPPPRHESYMLSNTL--------------G 969
            .|:|: .::||.:|:||||||:|:|::     |:|:||||:|||:::.:.              |
Mosquito   963 PEIEHAFNLEEPLTIDSGEGTMEHSMHHHHQQQVPQPPPRYESYLINGSATTYRGGIGGQPPHHG 1027

  Fly   970 TDGS---------------GSENY-----EMAPTRSLNSLNEERDISLDEIYDDNEKPKHLHQR- 1013
            ..||               |.:::     ::...||:|||::     ||.:....::.:.|||:
Mosquito  1028 HHGSQAQQQQTLAHPPQHGGQQHHQKLSQQLFDNRSINSLDD-----LDSLKQQAQQAQQLHQQQ 1087

  Fly  1014 ------------------------FQIFPPPTTPPEPAPPDHQLITCT----YKSQFVSASESSL 1050
                                    |||:||||||||||||||.||..:    .|:..||.|:|||
Mosquito  1088 PHQHSSMYYYEDSSDFDKGGSNQGFQIYPPPTTPPEPAPPDHLLIPASILRQLKADTVSQSQSSL 1152

  Fly  1051 EEITSDVSGSKDSLATHDAEWLED-----KSDGRRNMNKNLIWNNFSGSTHAYTTGRRHIDSNL- 1109
            |||.|||||||||:.|:|:.|::|     |.|.:::.:   :|.|.: :.||:|||||...|:.
Mosquito  1153 EEINSDVSGSKDSINTYDSGWIDDGFLIQKQDNKQSED---LWKNMN-AHHAFTTGRRPNQSSFA 1213

  Fly  1110 NKIRPKGPSQTLKVGEAPSRNCPAMSSSTFTLPTQQPGKLNMKNFQLVSDAVAKMNFTGSGSGSG 1174
            .||||||||||||                      ||||||:|:|.:|::|:|:||..|.|.|.|
Mosquito  1214 KKIRPKGPSQTLK----------------------QPGKLNLKSFAIVNEAIARMNIGGGGGGGG 1256

  Fly  1175 SGSGSGSTGLGLGLGSGSGCMGDSFLEPVDKDGKR-----------YDHAQLDGEDEDSEEL--- 1225
            :|...|::|...||           :...:|:.|:           .:||.|...::||||.
Mosquito  1257 AGGDGGASGANAGL-----------VPMTEKERKKAKKLLQQQQAQLEHAPLAAPEDDSEEYEDE 1310

  Fly  1226 ---------------------------------------------------------------AE 1227
                                                                           .|
Mosquito  1311 AGYEQINDAFSDAVNNVASQLFTTFSGGPGANHGGRGGGGGGGGADSSGGSEMGTHKTKLRQRRE 1375

  Fly  1228 YEQIYENEDCTESDSCASSTERRVRQQNAYYKASKKPVAAKKQKKKKVAIPVQTPRVP--PFGSY 1290
            .|||:..::.::|:|.:||.||: |..:.|.|.::|....|:.:||:.|||||.|::|  ||||.
Mosquito  1376 KEQIFNIQENSDSESDSSSLERK-RSNDGYSKINRKAQPHKRHRKKRTAIPVQPPKIPLGPFGSS 1439

  Fly  1291 VSP------------PEIPLHYQRMAVG-GSGPGEKKKP-----EPCVPEFMKSDKSPEYSMVPE 1337
            ...            ..:|:.||::... |||..::.||     |..|......|.||.:.::|:
Mosquito  1440 AGDMMGGVGASGGPLGGMPIMYQKLKNELGSGLEKQDKPSQEPDESSVDISSPRDNSPIFGVLPK 1504

  Fly  1338 LAGAGIFGAENLPEYNMNQAKCLKDFEKL---EKRRIKEETARQRKLQEKEKE---QEKKLKRKL 1396
                   |:               |.|||   :|....:|.....|..::.|:   ..|...:..
Mosquito  1505 -------GS---------------DREKLITKQKNWFGKEIDPAGKASKESKDARGSSKGASKNS 1547

  Fly  1397 KQNAKGLVESAEAQFGKLMITS----EQGE----IPIFLNKCVEFIEKEGLDSEGIYRVPGSRAH 1453
            |.|......:|.|....|..:|    :|.:    :|:|:.|||:|||:|||||||||||||:|.|
Mosquito  1548 KHNGAAAAAAAAAAAAALQQSSLASLKQSDKVPLVPLFVEKCVKFIEQEGLDSEGIYRVPGNRTH 1612

  Fly  1454 VDMLFQRFEEDTNTEIDALDIPVNAVATALKDFFSKRLPPLFSKDIIKELEEIAGSRGVGN-SKL 1517
            ||:|.|:|.|:::.:|:.||||||||||||||||.|||..|||.:::.|||||||||.:.: :.|
Mosquito  1613 VDLLNQKFAEESDVDIEKLDIPVNAVATALKDFFVKRLKGLFSAEMMSELEEIAGSRPLQSITSL 1677

  Fly  1518 NVEVKTDRSCRLIALKSLLQKLPPINFAILKYIFQHFVHVSDNSKLNSMDSKNLAICWWPTLIPI 1582
            |:|||||||||||||:.||.||||.|||||.|||||||.||:||||||||||||||||||||:||
Mosquito  1678 NMEVKTDRSCRLIALRGLLNKLPPNNFAILSYIFQHFVRVSENSKLNSMDSKNLAICWWPTLLPI 1742

  Fly  1583 DFTDMGHFEQLRPYLEDIVQTMIDQFPYLFCGKDAFVMV 1621
            :||||..||.:||||||||||||||:|:||||::|||||
Mosquito  1743 EFTDMMRFETMRPYLEDIVQTMIDQYPFLFCGEEAFVMV 1781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAPp190	NP_001259658.1	P-loop containing Nucleoside Triphosphate Hydrolases	<148..238	CDD:476819	69/89 (78%)
		RhoGAP-FF1	254..333	CDD:465153	46/78 (59%)
		pseudoGTPaseD_p190RhoGAP	598..748	CDD:412064	54/154 (35%)
		RhoGAP_p190	1411..1611	CDD:239838	142/208 (68%)
RhoGAPp190	XP_061498709.1	None