DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stas and Tmem41b

DIOPT Version :9

Sequence 1:	NP_573225.1	Gene:	stas / 32737	FlyBaseID:	FBgn0030850	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_001012358.1	Gene:	Tmem41b / 361626	RGDID:	1310870	Length:	291	Species:	Rattus norvegicus

Alignment Length:	246	Identity:	130/246 - (52%)
Similarity:	175/246 - (71%)	Gaps:	0/246 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 EKKATKKSLVIVAGIFVASLVTMCYVYAIFPELNASEKQHLKIPRDIQDAKMLAKVLDRYKDMYY 138
            |..:.:.||:|:..||..:...|..||..||:|:..|:.::|:|||:.|||.|.|||.:|||.:|
  Rat    46 EAGSARTSLLILVSIFSCAAFVMFLVYKNFPQLSEEERVNMKVPRDMDDAKALGKVLSKYKDTFY 110

  Fly   139 FEVMFGVVVAYVFLQTFAIPGSLFLSILLGFLYKFPIALFLICFCSALGATLCYTLSNLVGRRLI 203
            .:|:......|:||||||||||:|||||.||||.||:||||:|.||.|||:.||.||.||||.::
  Rat   111 VQVLVAYFATYIFLQTFAIPGSIFLSILSGFLYPFPLALFLVCLCSGLGASFCYMLSYLVGRPVV 175

  Fly   204 RHFWPKKTSEWSKHVEEYRDSLFNYMLFLRMTPILPNWFINLASPVIGVPLHIFALGTFCGVAPP 268
            ..:..:|..:||:.||.:|:.|.||::|||:||.|||||||:.||||.|||.:|.:|||.|||||
  Rat   176 YKYLTEKAVKWSQQVERHREHLINYIIFLRITPFLPNWFINITSPVINVPLKVFFIGTFLGVAPP 240

  Fly   269 SVIAIQAGKTLQKMTSSSEAFSWTSMGILMACACASLLPGLLKNKFKHKKE 319
            |.:||:||.||.::|::.||.||.|:.|||..|..|:||.:.:.|.|.|.|
  Rat   241 SFVAIKAGTTLYQLTTAGEAVSWNSVFILMILALLSILPAIFQKKLKQKFE 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stas	NP_573225.1	SNARE_assoc	157..276	CDD:286425	73/118 (62%)
Tmem41b	NP_001012358.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		SNARE_assoc	129..248	CDD:401323	73/118 (62%)
		VTT domain, required for its function in autophagy. /evidence=ECO:0000250\|UniProtKB:Q5BJD5	140..251		66/110 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346739
Domainoid	1	1.000	166	1.000	Domainoid score	I3794
eggNOG	1	0.900	-	-		E1_COG0398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H42740
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2877
OMA	1	1.010	-	-		QHG54676
OrthoDB	1	1.010	-	-		D1222755at2759
OrthoFinder	1	1.000	-	-		FOG0001464
OrthoInspector	1	1.000	-	-		oto96796
orthoMCL	1	0.900	-	-		OOG6_102890
Panther	1	1.100	-	-	LDO	PTHR43220
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2798
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770