Protein Alignment CG43658 and Arhgef17

DIOPT Version :10

• Sequence 1: NP_001259643.1
• Gene: CG43658 / 32729
• FlyBaseID: FBgn0263706
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_001074585.1
• Gene: Arhgef17 / 207212
• MGIID: 2673002
• Length: 2057
• Species: Mus musculus
• Alignment Length: 2176
• Identity: 446/2176 - (20%)
• Similarity: 760/2176 - (34%)
• Gaps: 635/2176 - (29%)

  Fly    71 QQKLQQQQQQQQQQQLEAVHGGVAKQCLQFPPP-------------PDYPPPITGGGGSPVNTTP 122
            :::.|.|||::.|:..:.:|...:     |..|             ..||...:....|......
Mouse   196 RRRRQHQQQERAQRPADGLHSWHS-----FSQPQAGARASSSSSIASSYPVSRSRAASSSEEEEE 255

  Fly   123 GRRQQL-PRYP----------DPDPDAIEICNESATLETSPYHLKQLAARHSKTLGRNLGHQPHH 176
            |.:.|| |:.|          |.||:..:                     ..:..||.|  :|..
Mouse   256 GPQSQLGPQSPAYLGGHSSGSDEDPNGED---------------------GRRWRGRGL--RPGR 297

  Fly   177 HHTVHLHHDYSYAYYEPGAAMRHSNVPGAVSSGGGGGGGGAGRV-------SSVVDTSSSSSPTA 234
            ...||            |.    |.....::.||.|..||.|..       :|:.:..:.:.|..
Mouse   298 SQLVH------------GC----SQDSDELNPGGLGSAGGVGSPEPPTSPRTSMDEWGTGTQPCL 346

  Fly   235 EPPPNSIRAL---------LSKGKKNKQLVSPATLQSYQTRYHKLTT---------KSGMGQSEN 281
            ..|..|:|.:         ::|......|.|||..:. .:||....|         :|.:|
Mouse   347 PGPQESLRPMSDTGGAPFRVAKVSFPAYLASPAGSRG-SSRYSSTETLKDDDLWSSRSSVG---- 406

  Fly   282 FYEEINAAALQTSSGHHLRSTVGSHSAGSLN--QTLVEEELRRVQNRHHKILGELNLSVEAMLMP 344
             :....:.:..|..|..||....|.|.|.:.  :.|.:..|...:||..|.|...:::.|.:.:.
Mouse   407 -WGVYRSPSFGTGDGLLLRPQTRSRSKGPVGTARPLRDGGLDLDKNRQRKSLSNPDIASETLTLL 470

  Fly   345 ESPPKSIDQQPLGSGSGGSGG---------AEATPPQPSVSVTAASGQPPT-------ILARLTS 393
            ......:.:..:...|||.|.         :..:|.:.|.|..:.|...||       :.|.|..
Mouse   471 SFLRSDLSELRVRKPSGGPGNRPLDGRDSPSAGSPMEQSESTLSQSPTSPTTRPTLKDLTATLRR 535

  Fly   394 ASADNICDSGGEAGKRTKTAPGCPGGGVEQLLTTTCGDLDSGFSGSSGASYIGSLRLSKTQHIKC 458
            |.:.: |.....|.:..:|:...|... |.||            ..|||.......:.:.|:::.
Mouse   536 AKSFS-CSEKPMARRLLRTSALKPSSS-ELLL------------AGSGAEEDPLPLVVQDQYVQE 586

  Fly   459 ARQT----PTVGTQSCRSFQRAATVYDEAGMSGGGGQS------GSSFLTRASCGRRILSCARIR 513
            |||.    ..:|.|.........|..|.||....|.:|      ..|.||....|
Mouse   587 ARQVFEKIQRMGAQQDDGNDVCPTSPDWAGDMTQGHRSQEELSGPESNLTDEGIG---------- 641

  Fly   514 AAEDPGP------------------------NHRIA-------GGNGIQTVQTTATESKARSFWS 547
              .||.|                        ||.:.       ||..:.:.:|..|....|
Mouse   642 --ADPEPLGAAFCSLDPAGVWRPLSSTSAQTNHHLGAGTEDSLGGRALVSPETPPTPGALR---- 700

  Fly   548 RKGWRKLPGFSTSTSSINDTGLSDEHKLNSGSWEDTLDEPHHHHAHHSHH--------------- 597
            |:  ||:|....:.:.:::...|:.::    |..|.:  |..|.|..|..
Mouse   701 RR--RKVPPSGPNGTELSNGEASEAYR----SLSDPI--PQRHRAATSEEPSGFSVDSNLLGSLN 757

  Fly   598 -----------QQHLHQHHSHLSQRHQQQQQQQQQLQQTSFIGSPPSSASITTAQLHSAFSR--- 648
                       .:.|...||..|...::.:..|:.:|  |.:..|            .|..|
Mouse   758 SKTGLPVTPAMDEGLTSGHSDWSVVSEENKDYQEVIQ--SIVQGP------------GALGRMGE 808

  Fly   649 -RIAEQ--RERDQRDQRDQREAVGCTAATIAGGSFSANGGQAAVGVGVGSSSSCGSSSERDTKSP 710
             |||.:  :::...|...:.|        :.|..|...||:                       |
Mouse   809 DRIAGKTPKKKSLSDPSRRGE--------LTGPGFEGPGGE-----------------------P 842

  Fly   711 CRERDRNLERDRDRERDKNDDLGEEEVLTEE--EQTSSSVSSLSAGNQRNSQLRSTFNKAKQHLS 773
            .||.:..|...           ..|.:|.|:  |....:.:...|.::|:.......:.|.....
Mouse   843 IREVEPMLPPS-----------SSEPILAEQWTEPEDPAPARGRAQSERSLPAPPASSTAHHDFH 896

  Fly   774 FDKWRTAATG---SATGSASGPGSSATDSNNAASNMIMRRASACTMPSSGGGGGAGVGSSQREEA 835
            .|...|:...   :..||...|..|        |:..:|                      |||.
Mouse   897 LDPKLTSVLSPRLTRRGSKKRPARS--------SHQELR----------------------REEG 931

  Fly   836 TTPGESPGGRLSRWFSIRRGSSHQYDVGGRDGRHSTASSFDT----PDSGSGNSPKNGSNAVAG- 895
               .:...|.|::   .|..|.|.        ||::..:..|    |:......|...:....|
Mouse   932 ---NQDQTGSLTQ---TRSSSKHV--------RHASVPATFTPIVVPEPAMSVGPPVAAPEPVGF 982

  Fly   896 --TGGAGSQGVALDAASPQKLANLGASKM-MPGVPESEDDEATANRFDVDLMMTPGS-------R 950
              .|....|..:|:..:.:.:..|.:..: .||              .|||...|.|       :
Mouse   983 PVRGHPALQAPSLEDVTKRYMLTLHSGDVPAPG--------------PVDLPCLPPSAPPSTETK 1033

  Fly   951 ANGTARTAHNRLIVPMLPPAPAG--LSQQQL-KRRHIVAAIVHSENSYVATLQRLVNDYKKPLEE 1012
            .:|.||...:.       ||||.  .|:.|: .|:|:...::.:|.|||.:|:.|:..|.:||::
Mouse  1034 PSGAARATPDE-------PAPASKCCSKPQVDMRKHVTMTLLDTEQSYVESLRTLMQGYMQPLKQ 1091

  Fly  1013 ------CSPPVLNPVKIATLFHCLPDILHSHKLFRISLAECVRNWDRDEKIGDCFVSAFGKPQLL 1071
                  |.|.:::.:     |..:|::|..|:.|...:..||:.|...:|:|...|.:|.|..|:
Mouse  1092 PENSLLCDPSLVDEI-----FDQIPELLEHHEQFLEQVRHCVQTWHAQQKVGALLVQSFSKDVLV 1151

  Fly  1072 EIYSGFINNFSAAMELAKMEEKRKSALADFFKVKQISAHDRLSFFGLMVKPVQRFPQFILFLQDL 1136
            .|||.:|:||..|.:..::.::.:.|...|.:.......::.:...||:|||||.|::.|.::||
Mouse  1152 NIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDL 1216

  Fly  1137 LKYTPQGHHDRMSLQLALSQLELLAELLNESKREAEQYQ----AFKEMLGHISGTFNARSLSLSS 1197
            ||:||:.|.|...|..|...::.:||.:|:..|.||:.:    ..:|:..||.|..:.::
Mouse  1217 LKHTPEDHPDHPLLLDAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQA----- 1276

  Fly  1198 VSVSDSAGGHRP-RYLLREDNVTHMEFNQAGFIVKCKQRRLLLLNDKVICVSVAPKQ-------- 1253
                       | |..||::.|..::     .|...|.|.|.|..|.::|.::..|.
Mouse  1277 -----------PLRRFLRQEMVIEVK-----AIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSM 1325

  Fly  1254 -----SHDFGATEKLTFKWMFPVNDVEIVDNSTSATLSRILTAGLNRGGSLKSNGSSGANGSPYA 1313
                 :.......|....|..|:.|.:|:..::.||....:...::|   |..:
Mouse  1326 SLYTAASVIDTASKYKMLWKLPLEDTDIIKGASQATNRETIQKAISR---LDED----------- 1376

  Fly  1314 NSTLPGHGGGVSGFS-GFGDPHSSPAAQLTNGADNLCSEMSTLMYDYEVISRIQDLVSSLKGSYK 1377
            .:||    |.:|..| ..|.||.|        .|:...::|..|  :..:|..|.|..||.....
Mouse  1377 LATL----GQMSKLSESLGFPHQS--------LDDALRDLSAAM--HRDLSEKQALCCSLAFPPT 1427

  Fly  1378 ELNANTTRNV---------------LNLIQGSIQRKDEEMAWVDSCC----LQLIGRHKSGKEET 1423
            :|....||..               |...|...:.| .::|...||.    |:.|...|:.....
Mouse  1428 KLELCATRPEGTDSYIFEFPHPDARLGFEQAFDEAK-RKLASSKSCLDPEFLKAIPIMKTRSGMQ 1491

  Fly  1424 F-----TFQTQTPAVKKEWIT-------ELRLAQLALDPNNS----------------PAWERGG 1460
            |     ||.:......:.|:.       ::.|..|..:|:..                |     |
Mouse  1492 FSCAAPTFSSCPEPAPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVP-----G 1551

  Fly  1461 SHPQPAHHHPHHHPLQHPHAGAGDPRQTQE----QLQLQEAVQQKQSRKMP-------------- 1507
            ..|:.....|  .||::|      |..|.|    :|.::...:::.:..:.
Mouse  1552 LQPRCPREQP--EPLRNP------PETTLESTGPELDVEATAEEEAATTLAEPGPQPCLHISISG 1608

  Fly  1508 --LFVKAMPVYKSQHQTEVRCGCYYSIANDTKQSGNARRRHKQLNYLWMCSSDGT--------SS 1562
              |.::..|. |...|.|:  ..:.|.::|......:.....|.:...:.||.|.        ::
Mouse  1609 SGLEMEPGPA-KGDPQPEL--VPFDSDSDDESSPSPSGTLQSQASQSTISSSFGNEETPSSKEAT 1670

  Fly  1563 HITVLAQHPQQAGNLREAGAF------------DLFETQVSALEFVKG-LDQLKSRDEPASLLGD 1614
            ..|..::..|:.|.|..:|:|            .....:.|...|.:| |:.|.|.|..|  ...
Mouse  1671 AETTSSEEEQEPGFLSLSGSFGPGGPCGTSPMDGRALRRSSRGSFTRGSLEDLLSVDPEA--YQS 1733

  Fly  1615 LVWLGTDSRKILIYSA-------RNPEQEEQLGSYSVPGAVQRILYHFDAVYVALSGATVLIFRR 1672
            .|||||:...:.:|.:       ||..:.:...|      |..|||..:.|:|:|:...:::::|
Mouse  1734 SVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAAS------VTCILYLNNKVFVSLANGELVVYQR 1792

  Fly  1673 GNDGVWQLRDPQTIR---LGDTDLVVPSLLPINMCIYASCGNRVYVMNALNGEIQRSFEVQHGAT 1734
            .....|   |||..:   ||.....:..::.:...::..|.|||.|::....:::.:|.|...::
Mouse  1793 EAGRFW---DPQNFKSMTLGSQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHTFYVGQDSS 1854

  Fly  1735 QQVNLMAHSGIGLWISLKNSTMLCLYHTETFKHLQDINIASSVLRHDGKKEQPLNN---SSVYVT 1796
            :.|..|..|.:|:|::||.|..:||||.:||:.|.::::...|.|.....:..:..   :.:.:|
Mouse  1855 RSVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRIT 1919

  Fly  1797 ALMACKGLLWVGTNVGIAVTIP-------LPRLEGVPIISGGINMSCHAHFGPITFL----LP-- 1848
            ||:.|..||||||:.|:.:|||       .||   .|:...|:   |..|.|.:.||    ||
Mouse  1920 ALLVCAELLWVGTSAGVVLTIPTSPSTVSCPR---APLSPAGL---CQGHTGHVRFLAAVQLPEG 1978

  Fly  1849 --LIPKVYPAYKPPTVGAAPLVPSMGDDLQLPAID------------ADPKIQELDDGAVVLRRD 1899
              |:....|   ||        |..|.: :||::|            |.||:..:..|.
Mouse  1979 FNLLCSTPP---PP--------PDTGPE-KLPSLDHRDSPRRRGPTSARPKMLVISGGD------ 2025

  Fly  1900 LAKEEMSSSNPGADSTASSPRSSKLDKQNSL 1930
             ..|:...|:.|..|:.:..|.   |..|.|
Mouse  2026 -GSEDFRLSSGGGGSSETVGRD---DSTNHL 2052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43658	NP_001259643.1	RhoGEF	984..1153	CDD:459876	52/174 (30%)
		PH_19	1210..1376	CDD:465965	38/179 (21%)
		WD40_2	1551..>1846	CDD:465964	85/335 (25%)
Arhgef17	NP_001074585.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..361		38/208 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	375..461		22/91 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..559		16/78 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	615..647		10/43 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	663..952		65/400 (16%)
		PHA03247	<851..1048	CDD:223021	45/272 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1054		13/59 (22%)
		RhoGEF	1060..1245	CDD:238091	57/189 (30%)
		PH_19	1274..1395	CDD:465965	29/159 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1555..1713		26/168 (15%)
		WD40_2	1718..>2017	CDD:465964	88/327 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1983..2050		18/88 (20%)