DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nprl2 and NPR2

DIOPT Version :9

Sequence 1:	NP_573174.1	Gene:	Nprl2 / 32677	FlyBaseID:	FBgn0030800	Length:	412	Species:	Drosophila melanogaster
Sequence 2:	NP_010852.4	Gene:	NPR2 / 856647	SGDID:	S000000788	Length:	615	Species:	Saccharomyces cerevisiae

Alignment Length:	501	Identity:	116/501 - (23%)
Similarity:	184/501 - (36%)	Gaps:	158/501 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 IRCIFLSEFHATAGCKISCQVPDNYISKD--VFDAINVYIIPKQHLQRCILTVNAMDVKIVGYPV 102
            |..||.|.||.|.|.||..:.|.|.:...  .|:....|||||..|...::|......:||.|||
Yeast    11 IHTIFYSVFHPTEGSKIKYEFPPNNLKNHGINFNTFKNYIIPKPILCHKLITFKYGTYRIVCYPV 75

  Fly   103 GIQDQQKYARNAFLFNLCFVCDSRARSVQYEPVVKKLSEYLIMMEEESCFLSRED---------- 157
            .| :...||||.|.||..||......:..|||.:.:|.:...::||::..||:.:
Yeast    76 TI-NSPIYARNFFSFNFVFVFPYDCETSPYEPAITRLGKMFKVLEEQNQLLSKSERDPVFFDLKV 139

  Fly   158 -----------------------------------DKR------------------RLQNIFETV 169
                                               |.|                  .:|::...:
Yeast   140 LENSTTTPSTAGPSSTPNPSSNTTPTHPTSEKDTKDMRSSRYSDLIKDLGLPQSAFSIQDLLMRI 204

  Fly   170 LRDLNERKVATI-VEGDNTIYLKIV-MHKPDPPPVKDHMVPLLLANLRDAPLDNWDLTTQQILPY 232
            .:|||......| ::..|.:.:||. :.:|....|....|||...||:.....|||.|...|:||
Yeast   205 FQDLNNYSECLIPIDEGNAVDIKIFPLLRPPTTCVSLEDVPLSSVNLKKIIDVNWDPTMMSIVPY 269

  Fly   233 INGINHVARIAAEADVETDLVKSCIQNLVYYGVVQLLPILKYSNVYMTQNL-KHLIQSASLSGAC 296
            |:|:|.:|:|:..::.:..||..||::|:||..|.|..|.::||:|...:| ::.:....::..|
Yeast   270 IDGLNSIAKISKLSNSDPGLVIECIRHLIYYKCVTLSDIFQFSNIYAPSSLIRNFLTDPLMASDC 334

  Fly   297 RKYVAL--------------------------------------RPD------------------ 305
            :.||..                                      .||
Yeast   335 QSYVTFPEVSKISNLPLNKSLGSGDQDSPSFSVRRKSKSSSIPSNPDSRTTSFSSTSRVSQNSSL 399

  Fly   306 ------------------------------KTLPSVQRIFQFYASMTHGVTLRAICQR--LCPQH 338
                                          :.||:...:|..|.|::.|.||:...:.  :..:.
Yeast   400 NSSFSSIYKDWRQSQTSCSSSNIHVINNRNRFLPTRSCLFDLYRSLSQGQTLKTWYESKYMILKE 464

  Fly   339 HNIDERRMVIFGLQHRFIRCIHKYPVFTGSVPSGRQKMYTGLISFD 384
            :|||.||.:.|||:.|.|...:.:||.. :..|...|..|.:|:.|
Yeast   465 NNIDIRRFITFGLEKRIIYRCYSFPVMI-NAGSREPKEMTPIITKD 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nprl2	NP_573174.1	NPR3	40..403	CDD:305178	116/501 (23%)
NPR2	NP_010852.4	NPR3	9..490	CDD:420157	109/479 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346137
Domainoid	1	1.000	104	1.000	Domainoid score	I1482
eggNOG	1	0.900	-	-		E1_KOG3789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4771
Inparanoid	1	1.050	106	1.000	Inparanoid score	I1414
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005663
OrthoInspector	1	1.000	-	-		oto99309
orthoMCL	1	0.900	-	-		OOG6_103955
Panther	1	1.100	-	-	LDO	PTHR12991
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R837
SonicParanoid	1	1.000	-	-		X4639
TreeFam	1	0.960	-	-
	14	13.780