Protein Alignment Nprl2 and NPRL2

DIOPT Version :8

• Sequence 1: NP_573174.1
• Gene: Nprl2 / 32677
• FlyBaseID: FBgn0030800
• Length: 412
• Species: Drosophila melanogaster
• Sequence 2: NP_006536.3
• Gene: NPRL2 / 10641
• HGNCID: 24969
• Length: 380
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 176/393 (45%)
• Similarity: 253/393 (64%)
• Gaps: 16/393 (4%)

  Fly    24 GSGAGAAGAHGSTEGKIRCIFLSEFHATAGCKISCQVPDNYISKDVFDAINVYIIPKQHLQRCIL 88
            |||.           :|.|||.||||.|.|.||:.|||:::||:::||.:.||||.|..||..::
Human     2 GSGC-----------RIECIFFSEFHPTLGPKITYQVPEDFISRELFDTVQVYIITKPELQNKLI 55

  Fly    89 TVNAMDVKIVGYPVGIQDQQKYARNAFLFNLCFVCDSRARSVQYEPVVKKLSEYLIMMEEESCFL 153
            ||.||:.|::|.||.| :.:||:|||.||||.||||::|::...||:||||:.||..:|.||.|:
Human    56 TVTAMEKKLIGCPVCI-EHKKYSRNALLFNLGFVCDAQAKTCALEPIVKKLAGYLTTLELESSFV 119

  Fly   154 SREDDKRRLQNIFETVLRDLNERKVATI-VEGDNTIYLKIVMHKPDPPPVKDHMVPLLLANLRDA 217
            |.|:.|::|..|...:|.:||.....|: ::..|||:||::..:||||..:::.||:...:..|.
Human   120 SMEESKQKLVPIMTILLEELNASGRCTLPIDESNTIHLKVIEQRPDPPVAQEYDVPVFTKDKEDF 184

  Fly   218 PLDNWDLTTQQILPYINGINHVARIAAEADVETDLVKSCIQNLVYYGVVQLLPILKYSNVYM-TQ 281
            ....||||||||||||:|..|:.:|:||||||.:||:..||||:|||||.|:.||:|||||. |.
Human   185 FNSQWDLTTQQILPYIDGFRHIQKISAEADVELNLVRIAIQNLLYYGVVTLVSILQYSNVYCPTP 249

  Fly   282 NLKHLIQSASLSGACRKYVALRPDKTLPSVQRIFQFYASMTHGVTLRAICQRLCPQHHNIDERRM 346
            .::.|:...||..||..||..:..|. .|::.:||.|.|::.|.|:|.:..|...|..::|||::
Human   250 KVQDLVDDKSLQEACLSYVTKQGHKR-ASLRDVFQLYCSLSPGTTVRDLIGRHPQQLQHVDERKL 313

  Fly   347 VIFGLQHRFIRCIHKYPV-FTGSVPSGRQKMYTGLISFDEICCKTGLSPCTIERDIEKDTNVTVI 410
            :.|||....||.:.|||| .|....|...::|||..|:||||||||:|...::..:|.|.|:.:.
Human   314 IQFGLMKNLIRRLQKYPVRVTREEQSHPARLYTGCHSYDEICCKTGMSYHELDERLENDPNIIIC 378

  Fly   411 WK 412
            ||
Human   379 WK 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nprl2	NP_573174.1	NPR3	40..403	CDD:305178	169/366 (46%)
NPRL2	NP_006536.3	Interaction with PDPK1. {ECO:0000269|PubMed:18616680}	1..133		69/143 (48%)
		NPR3	7..370	CDD:329240	168/365 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C187337342
eggNOG	1	0.900				E1_KOG3789
Hieranoid	1	1.000
Homologene	1	1.000				H4771
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2394
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D500740at2759
OrthoFinder	1	1.000				FOG0003867
OrthoInspector	1	1.000				T1075086
orthoMCL	1	0.900				OOG5_129933
Panther	1	1.100			LDO	PTHR12991
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R837
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	14	13.800