Protein Alignment r and TMEM116

DIOPT Version :10

• Sequence 1: NP_523377.1
• Gene: r / 32640
• FlyBaseID: FBgn0003189
• Length: 2224
• Species: Drosophila melanogaster
• Sequence 2: NP_001180460.1
• Gene: TMEM116 / 89894
• HGNCID: 25084
• Length: 337
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 55/296 - (18%)
• Similarity: 106/296 - (35%)
• Gaps: 72/296 - (24%)

  Fly   371 MESIQQKDLTIPQLIEQRLRPTTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRE 435
            |:..|....|.|.:|:...|....|...:.::|   |:|.:....:|...|...:.||:.|.:
Human    93 MKHTQSGQSTSPLVIDYTCRVCQMAFVFSSLIP---LLLMTPVFCLGNTSECFQNFSQSHKCI-- 152

  Fly   436 SNIQTVLINPNIATVQ----TSKGMADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGV 496
                 ::.:|..|..:    .:..:....||.                 |:.:..|
Human   153 -----LMHSPPSAMAELPPSANTSVCSTLYFY-----------------GIAIFLG--------- 186

  Fly   497 QLERAGVFSKYNVRILGTPIQSIIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYP 561
                :.|.|...:.:|....|::.     |.|.:....:|.:      .::|...:|...|. ||
Human   187 ----SFVLSLLTIMVLLIRAQTLY-----KKFVKSTGFLGSE------QWAVIHIVDQRVRF-YP 235

  Fly   562 VMARAAFSLGGLG--------SGFANNEEELQSLAQQALAHSSQLIVDKSLKGW-----KEVEYE 613
            |   |.|...|..        :...:.:..:.....|||..:||.:::..:.||     .:::.|
Human   236 V---AFFCCWGPAVILMIIKLTKPQDTKLHMALYVLQALTATSQGLLNCGVYGWTQHKFHQLKQE 297

  Fly   614 VVRDAYNNCITVCNMENFDPLGIHTGESIVVAPSQT 649
            ..|||......:|:.:.|...|:::.||.:..|:.|
Human   298 ARRDADTQTPLLCSQKRFYSRGLNSLESTLTFPAST 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_523377.1	CPSaseIIsmall	7..376	CDD:273580	1/4 (25%)
		CPSaseII_lrg	403..1455	CDD:273581	48/264 (18%)
		CAD_DHOase	1475..1821	CDD:238641
		PyrB	1913..2221	CDD:440306
TMEM116	NP_001180460.1	7tm_GPCRs	<178..285	CDD:475119	24/151 (16%)
		TM helix 6	229..250	CDD:320094	7/24 (29%)
		TM helix 7	259..285	CDD:320094	5/25 (20%)