Protein Alignment r and CPS1

DIOPT Version :10

• Sequence 1: NP_523377.1
• Gene: r / 32640
• FlyBaseID: FBgn0003189
• Length: 2224
• Species: Drosophila melanogaster
• Sequence 2: NP_001356185.1
• Gene: CPS1 / 1373
• HGNCID: 2323
• Length: 1511
• Species: Homo sapiens
• Alignment Length: 1477
• Identity: 751/1477 - (50%)
• Similarity: 1013/1477 - (68%)
• Gaps: 72/1477 - (4%)

  Fly     7 YLALEDGTVLPGYSFGYVPSENESKVGFGGEVVFQTGMVGYTEALTDRSYSGQILVLTYPLIGNY 71
            ::.|||||.:.|||||: ||      ...|||||.||:.||.||:||.:|.||||.:..|:|||.
Human    58 HIVLEDGTKMKGYSFGH-PS------SVAGEVVFNTGLGGYPEAITDPAYKGQILTMANPIIGNG 115

  Fly    72 GVPAPDE---DEHGLPLHFEWMKGVVQATALVVGEVAEEAFHWRKWKTLPDWLKQHKVPGIQDID 133
            |  |||.   ||.||..:.|  ...::.:.|:|.:.:::..||...|:|..||::.|||.|..:|
Human   116 G--APDTTALDELGLSKYLE--SNGIKVSGLLVLDYSKDYNHWLATKSLGQWLQEEKVPAIYGVD 176

  Fly   134 TRALTKKLREQGSMLGKIVYEKPPVEGLPKSSFVDPNVRNLAKECSVKERQVYGNPNGKGPRIAI 198
            ||.|||.:|::|:|||||.:|..||:      |||||.:||..|.|.|:.:|||  .|...::..
Human   177 TRMLTKIIRDKGTMLGKIEFEGQPVD------FVDPNKQNLIAEVSTKDVKVYG--KGNPTKVVA 233

  Fly   199 LDCGLKLNQLRCLLQRGASVTLLPWSARLEDEQFDALFLSNGPGNPESCDQIVQQVRKVIEEGQK 263
            :|||:|.|.:|.|::|||.|.|:||:......::|.:.::.|||||...:.::|.|||::|..:|
Human   234 VDCGIKNNVIRLLVKRGAEVHLVPWNHDFTKMEYDGILIAGGPGNPALAEPLIQNVRKILESDRK 298

  Fly   264 -PVFGICLGHQLLAKAIGCSTYKMKYGNRGHNLPCLHRATGRCLMTSQNHGYAVDLEQLPDGWSE 327
             |:|||..|:.:...|.|..||||...|||.|.|.|:....:..:|:||||||:| ..||.||..
Human   299 EPLFGISTGNLITGLAAGAKTYKMSMANRGQNQPVLNITNKQAFITAQNHGYALD-NTLPAGWKP 362

  Fly   328 LFVNANDGTNEGIVHASKPYFSVQFHPEHHAGPQDTEFLFDVFMESIQQ-KDLTIPQLIEQRLRP 391
            ||||.||.|||||:|.|||:|:||||||...||.|||:|||.|...|:: |..||..::.:
Human   363 LFVNVNDQTNEGIMHESKPFFAVQFHPEVTPGPIDTEYLFDSFFSLIKKGKATTITSVLPK---- 423

  Fly   392 TTPAIDSAPVMPRKVLILGSGGLSIGQAGEFDYSGSQAIKAMRESNIQTVLINPNIATVQTSK-G 455
              ||:.::.|...|||||||||||||||||||||||||:|||:|.|::|||:|||||:|||:: |
Human   424 --PALVASRVEVSKVLILGSGGLSIGQAGEFDYSGSQAVKAMKEENVKTVLMNPNIASVQTNEVG 486

  Fly   456 M--ADKCYFLPLTPHYVEQVIKSERPNGVLLTFGGQTALNCGVQLERAGVFSKYNVRILGTPIQS 518
            :  ||..||||:||.:|.:|||:|:|:|::|..||||||||||:|.:.||..:|.|::|||.::|
Human   487 LKQADTVYFLPITPQFVTEVIKAEQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVES 551

  Fly   519 IIETEDRKLFAERVNEIGEQVAPSEAVYSVAQALDAASRLGYPVMARAAFSLGGLGSGFANNEEE 583
            |:.||||:||::::|||.|::|||.||.|:..||.||..:|||||.|:|::|||||||...|.|.
Human   552 IMATEDRQLFSDKLNEINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRET 616

  Fly   584 LQSLAQQALAHSSQLIVDKSLKGWKEVEYEVVRDAYNNCITVCNMENFDPLGIHTGESIVVAPSQ 648
            |..|:.:|.|.::|::|:||:.||||:||||||||.:||:|||||||.|.:|:|||:|:||||:|
Human   617 LMDLSTKAFAMTNQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVVAPAQ 681

  Fly   649 TLSDREYQMLRSTALKVIRHFGVVGECNIQYALCPHSEQYYIIEVNARLSRSSALASKATGYPLA 713
            |||:.|:||||.|::.|:||.|:|||||||:||.|.|.:|.||||||||||||||||||||||||
Human   682 TLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYPLA 746

  Fly   714 YVAAKLALGLPLPDIKNSVTGNTTACFEPSLDYCVVKIPRWDLAKFVRVSKHIGSSMKSVGEVMA 778
            ::|||:|||:|||:|||.|:|.|:|||||||||.|.|||||||.:|...|..|||||||||||||
Human   747 FIAAKIALGIPLPEIKNVVSGKTSACFEPSLDYMVTKIPRWDLDRFHGTSSRIGSSMKSVGEVMA 811

  Fly   779 IGRNFEEAFQKALRMVDSDVLGFDPDVVPLNKE-----QLAEQLSEPTDRRPFVIAAALQLGMSL 838
            |||.|||:|||||||....:.||.|. :|:|||     .|.::||||:..|.:.||.|:...|||
Human   812 IGRTFEESFQKALRMCHPSIEGFTPR-LPMNKEWPSNLDLRKELSEPSSTRIYAIAKAIDDNMSL 875

  Fly   839 RELHQLTNIDYWFLEKLERIILLQSLLT-RNGSRTDAALLLKAKRFGFSDKQIAKYIKSTELAVR 902
            .|:.:||.||.|||.|:..|:.::..|. .|........|.:||..|||||||:|.:..||...|
Human   876 DEIEKLTYIDKWFLYKMRDILNMEKTLKGLNSESMTEETLKRAKEIGFSDKQISKCLGLTEAQTR 940

  Fly   903 HQRQEFGIRPHVKQIDTVAGEWPASTNYLYHTYNGSEHDVDFPGGHTIVVGSGVYRIGSSVEFDW 967
            ..|.:..|.|.||||||:|.|:|:.|||||.||||.||||:|.....:|:|.|.|.|||||||||
Human   941 ELRLKKNIHPWVKQIDTLAAEYPSVTNYLYVTYNGQEHDVNFDDHGMMVLGCGPYHIGSSVEFDW 1005

  Fly   968 CAVGCLRELRKLQRPTIMINYNPETVSTDYDMCDRLYFEEISFEVVMDIYEMENSEGIILSMGGQ 1032
            |||..:|.||:|.:.|:::|.||||||||:|.||:|||||:|.|.::|||..|...|.|:|:|||
Human  1006 CAVSSIRTLRQLGKKTVVVNCNPETVSTDFDECDKLYFEELSLERILDIYHQEACGGCIISVGGQ 1070

  Fly  1033 LPNNIAMDLHRQQAKVLGTSPESIDCAENRFKFSRMLDRKGILQPRWKELTNLQSAIEFCEEVGY 1097
            :|||:|:.|::...|::||||..||.||:|..||.:||...:.|..||.:..|..|:||.:.|.|
Human  1071 IPNNLAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPWKAVNTLNEALEFAKSVDY 1135

  Fly  1098 PCLVRPSYVLSGAAMNVAYSNQDLETYLNAASEVSREHPVVISKFLTEAKEIDVDAVASDGRILC 1162
            |||:||||||||:||||.:|..:::.:|..|:.||:|||||::||:..|:|:::|||..|||::.
Human  1136 PCLLRPSYVLSGSAMNVVFSEDEMKKFLEEATRVSQEHPVVLTKFVEGAREVEMDAVGKDGRVIS 1200

  Fly  1163 MAVSEHVENAGVHSGDATLVTPPQDLNAETLEAIKRITCDLASVLDVTGPFNMQLIAKNNELKVI 1227
            .|:|||||:||||||||||:.|.|.::...:|.:|..|..:|....::||||:|.:.|.|::.||
Human  1201 HAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVKDATRKIAKAFAISGPFNVQFLVKGNDVLVI 1265

  Fly  1228 ECNVRVSRSFPFVSKTLDHDFVATATRAIVGLDVE------------PLDVLHGVGKVGVKVPQF 1280
            |||:|.|||||||||||..||:..||:.::|.:|:            |.|.      |.:|.|.|
Human  1266 ECNLRASRSFPFVSKTLGVDFIDVATKVMIGENVDEKHLPTLDHPIIPADY------VAIKAPMF 1324

  Fly  1281 SFSRLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKNAVLLSI-GSFKHKMELLP 1344
            |:.||..||..|..||||||||||||:..:.|:||||:||||:||:..:|:.| .||:.:  .|.
Human  1325 SWPRLRDADPILRCEMASTGEVACFGEGIHTAFLKAMLSTGFKIPQKGILIGIQQSFRPR--FLG 1387

  Fly  1345 SIRDLAKMGYKLYASMGTGDFYAEHGVNVESVQWTFDKTTPDDINGELRHLAEFLANKQFDLVIN 1409
            ....|...|:||:|:..|.|:...:.|....|.|    .:.:..|..|..:.:.:.:...|||||
Human  1388 VAEQLHNEGFKLFATEATSDWLNANNVPATPVAW----PSQEGQNPSLSSIRKLIRDGSIDLVIN 1448

  Fly  1410 LPMSGGGARRVSSFMTHGYRTRRLAVDYSIPLVTDVKCTKLLVESMR 1456
            ||.:.      :.|:...|..||.|||..|||:|:.:.|||..|:::
Human  1449 LPNNN------TKFVHDNYVIRRTAVDSGIPLLTNFQVTKLFAEAVQ 1489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
r	NP_523377.1	CPSaseIIsmall	7..376	CDD:273580	172/372 (46%)
		CPSaseII_lrg	403..1455	CDD:273581	573/1073 (53%)
		CAD_DHOase	1475..1821	CDD:238641
		PyrB	1913..2221	CDD:440306
CPS1	NP_001356185.1	CPSaseIIsmall	57..411	CDD:273580	172/372 (46%)
		CPSaseII_lrg	430..1488	CDD:273581	574/1076 (53%)