Protein Alignment: LeuRS and LARS

• Sequence 1: NP_001285589.1
• Gene: LeuRS
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_064502.9
• Gene: LARS
• HGNCID: 6512
• Length: 1176
• Species: Homo sapiens
• Alignment Length: 1184
• Identity: 700/1185 (59%)
• Similarity: 889/1185 (75%)
• Gaps: 18/1185 (2%)

  Fly     5 ERKGTFKVEYLQKIEREVQQRWEAERVHESDAPTAPKKRQAEKFFVTFPFPYMNGRLHLGHTFSL 69
            |||||.||::|:|||:|:||:|:.|||.|.:|....|:....|:|||||:|||||||||||||||
Human     3 ERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSL 67

  Fly    70 SKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFP-ETEEVVPVAAEAA 133
            ||.|:::.|.||||:..|:|||.||||||||||||||.||:|.:|.||.|| |.||....:.:..
Human    68 SKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTE 132

  Fly   134 SEVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQDLKRIGV 198
            ..:.|||:|||||||.||.|::||||.||:||||.||||..|:.|||||:||||||:|||||:|:
Human   133 DIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGL 197

  Fly   199 HVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGKRYTIYSPKDGQPCMDHDRSSGEGVGPQ 263
            .|||||:|||||.|||:||||||||..|:||.||.:||||||||||||||||||||.:|||||||
Human   198 KVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQ 262

  Fly   264 EYTLIKMKVLE-VPKALSSIK-QPIFMVAATLRPETMYGQTNCWLHPDIKYIAWQANKNNEVWVS 326
            ||||:|:|||| .|..||.:| :.||:||||||||||:||||||:.||:|||.:: ..|.::::.
Human   263 EYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFE-TVNGDIFIC 326

  Fly   327 TRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPLTKHKVVYSLPMLSIKEDKGTGVVTS 391
            |::|||||:|||||...|.:.|:.|:.|:::||..||||||.:||:|.||||:||||||||||||
Human   327 TQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTS 391

  Fly   392 VPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEVPTLGKLSAVHAYETLKIQSQND 456
            ||||||||.|||.||:||:|.|.|||::|:||||:||:|:||:|..|.||||...:.||||||||
Human   392 VPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQND 456

  Fly   457 KDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQDVKKDLQKRLVDANEADVYYEPEKTIMSRSADE 521
            ::|||||||..|||.||:|:|||..|.|:|:|||||.:||:::||.:|.:|.||||.:||||:||
Human   457 REKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDE 521

  Fly   522 CVVALCNQWYLNYGEPEWQAQATKILHGMETFHEEARNNFEACLNWLHEYACSRTYGLGTKLPWD 586
            ||||||:||||:|||..|:.|.::.|..:|||.||.|.||||.|.||.|:||||||||||.||||
Human   522 CVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWD 586

  Fly   587 DKWLIESLSDSTIYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFFKETPLPKKTAI 651
            ::||||||||||||||||||.||||||...|:...|.||:|..||.|:|||:||||.|.| ||.|
Human   587 EQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFP-KTQI 650

  Fly   652 KQEHLAVLRREFEYWYPMDLRVSGKDLIQNHLTFCLYNHAAIWPNDENKWPKGMRVNGHLLLNSA 716
            .:|.|..|::|||:|||:|||||||||:.|||::.||||.|:||...:|||..:|.||||||||.
Human   651 AKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSE 715

  Fly   717 KMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANFVESTADAGILRLYTFIEWVKEMLEN 781
            |||||.|||||||:|:||||||||||.||||||:||||||||:.||||||||||::||||||:.|
Human   716 KMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN 780

  Fly   782 RSSLRKGTDKTFNDQVFLSELNLKTQQTDENYRKMLFKEALRSGFYELQLARDKYRELCGANGMH 846
            ..|||.|...||||:||.||||....:||:||.||:|||||::||:|.|.|:|||||| ...|||
Human   781 WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYREL-AVEGMH 844

  Fly   847 EDLVLEFIRRQALLVSPICPHMAEHVWGLLGNKESIVHARWPEVGAINEVDILCSEYLMEAAHSF 911
            .:||..||..|.||::|.|||:.||:|.|||..:||::|.||..|.:|||.|..|:||||..|..
Human   845 RELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDL 909

  Fly   912 RLNLKN-LLQIKGKAGKDKSVNVQAAKPNRGLVWVAKTYPPWQCCVLDTMKELFNKSQA-LPDNK 974
            ||.||| ::..|||    |:......||:...::|||.|||||...|..:::.|..:.. |||||
Human   910 RLRLKNYMMPAKGK----KTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNK 970

  Fly   975 VIAATLQQKAELKKFMKRVMPFAQMIREKVESGKGVAALAVTLEFDERQVLISNLEYLKNTLDLD 1039
            |||:.|....||||:||:||||..||:|.:|. .|...|.:.|||||:.||:.|:.||.|:|:|:
Human   971 VIASELGSMPELKKYMKKVMPFVAMIKENLEK-MGPRILDLQLEFDEKAVLMENIVYLTNSLELE 1034

  Fly  1040 VLEIKYTDDPSAPEKTREEVRPGSPFISFSVAPNVSVELTNPIERSSLFQVNTVISEGDTVQSLR 1104
            .:|:|:..:  |.:|.||:..||.|...|.:.|.|||.|.||...:..|.....|.:||...|:.
Human  1035 HIEVKFASE--AEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSII 1097

  Fly  1105 EKLSKI-IGLKTDAATLKIWRYEDPVLGPRKIPNF-EDYKAGKSVLGEGNFVLDVENKKVSLEQA 1167
            .:|.|: .|:| |.:.:|:.|::||:||||::|.. ::|.....:.....|.:|:.:||:.|.:.
Human  1098 RRLMKMNRGIK-DLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTEN 1161

  Fly  1168 GKLTEVGRNLIYVV 1181
            |...::|..:||:|
Human  1162 GIRVDIGDTIIYLV 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	662/1068 (62%)
		nt_trans	47..>204	CDD:294020	107/158 (68%)
		LeuRS_core	<525..758	CDD:173906	161/233 (69%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	74/120 (62%)
LARS	NP_064502.9	tRNA-synt_1g	5..1062	CDD:330949	661/1067 (62%)
		'HIGH' region	53..63		10/10 (100%)
		Editing domain	260..509		156/250 (62%)
		'KMSKS' region	716..720		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C327644270
eggNOG	1	0.900				E1_COG0495
Hieranoid	1	1.000
Homologene	1	1.000				H7083
Inparanoid	1	1.050	1428	1.000	Inparanoid score	I115
Isobase	1	0.950		0	Normalized mean entropy	S618
OMA	1	1.010
OrthoDB	1	1.010				D131349at33208
OrthoFinder	1	1.000				FOG0003696
OrthoInspector	1	1.000				T1074675
orthoMCL	1	0.900				OOG5_127407
Panther	1	1.100			LDO	PTHR45794
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R1447
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	14	13.840