Protein Alignment LeuRS and lrs1

DIOPT Version :10

• Sequence 1: NP_787968.1
• Gene: LeuRS / 326262
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_594882.1
• Gene: lrs1 / 2542670
• PomBaseID: SPAC26F1.13C
• Length: 1111
• Species: Schizosaccharomyces pombe
• Alignment Length: 1143
• Identity: 539/1143 - (47%)
• Similarity: 724/1143 - (63%)
• Gaps: 90/1143 - (7%)

  Fly     1 MATTE--------------RKGTFKVEYLQKIEREVQQRWEAERVHESDAPTA-----PKKRQAE 46
            |||||              .:.|.|.:.|.::|::.||:|:.|:..|.|||..     ..:::..
pombe     1 MATTEPSVEQLETKTAKLKLENTTKRDTLIELEKKYQQKWQEEKAFEVDAPLEDVPIDELRKKYP 65

  Fly    47 KFFVTFPFPYMNGRLHLGHTFSLSKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELE 111
            |||...|:|||||.|||||.|:|||.|::..:.||.|:|||:|.|||||||||.|.||:|:||:|
pombe    66 KFFGNMPYPYMNGALHLGHAFTLSKVEFTTAFERLNGKRVLFPMGFHCTGMPICASADRLSREIE 130

  Fly   112 QFGFPPQF---PETEEVVPVAAE---AASEVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDE 170
            .||  |.|   .|.||.|.|..:   |..:|  .|..||||||.|||.|.|||:|||:|||:...
pombe   131 MFG--PSFDVPEEKEEEVEVEVKTPNAREDV--TKHSGKKSKAAAKTAAVKYQFQIMESLGVPRT 191

  Fly   171 EIKDFANAEHWLNYFPPLAVQDLKRIGVHVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYG 235
            ||..||:|::||:|||||..:|....|:.:||||:|||||.|||:|||||||.|||.:.|||.:|
pombe   192 EIHKFADAKYWLSYFPPLCQRDCTEFGLGIDWRRSFITTDVNPYYDSFVRWQVNHLHDSGKIKFG 256

  Fly   236 KRYTIYSPKDGQPCMDHDRSSGEGVGPQEYTLIKMKVLEVP----KALSSI---KQPIFMVAATL 293
            :|||:||.|||||||||||.|||||||||||.|||:|||.|    |||.||   .:.:.|:||||
pombe   257 ERYTVYSIKDGQPCMDHDRKSGEGVGPQEYTGIKMEVLEFPEAARKALQSIDLSNKKVCMIAATL 321

  Fly   294 RPETMYGQTNCWLHPDIKYIAWQANKNNEVWVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLL 358
            |||||||||||::.|:|.|..:::|..||:::.|||||.||.||..:...|.:..|..:.||||:
pombe   322 RPETMYGQTNCYVGPNITYGIYESNVPNELFICTRRAANNMAYQKLSKERGVVSELGTIKGQDLI 386

  Fly   359 GVPLSAPLTKHKVVYSLPMLSIKEDKGTGVVTSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMV 423
            |..::|||:.||.||.|||.::...||||||||||||||||:|.|.:|:||..|   |.|..|.
pombe   387 GALVNAPLSVHKQVYVLPMETVLATKGTGVVTSVPSDSPDDFATLTELRKKAEF---YHLNPEW- 447

  Fly   424 LPYEPIPIIEVPTLGKLSAVHAYETLKIQSQNDKDKLAEAKEMCYLKSFYDGVMLVGAFAGRKIQ 488
            :.||.:|||..|:.|.:.|....:.|||||..|..:||:|||:.|.:.||.|.|::|.::|.|::
pombe   448 MKYEAVPIIRTPSYGDMCAEFLCKKLKIQSPKDVKQLAQAKELAYKECFYQGTMIIGKYSGEKVE 512

  Fly   489 DVKKDLQKRLVDANEADVYYEPEKTIMSRSADECVVALCNQWYLNYGEPEWQAQATKILHGMETF 553
            ..|..::|.|:|...|.||.|||..::|||.|:|:||||:||:|:|||..|:|...|.|..:.||
pombe   513 TAKPKVRKELIDQGLAFVYNEPEGQVISRSGDDCIVALCDQWFLDYGEASWKAVTEKALDRLNTF 577

  Fly   554 HEEARNNFEACLNWLHEYACSRTYGLGTKLPWDDKWLIESLSDSTIYMAFYTVVHLLQGGTFRGE 618
            ..|.||.|...|:||.::||:|:|||||:||||.::|:|||:|||||||:||:.|||....: |:
pombe   578 SPEVRNGFLKTLDWLSQWACARSYGLGTRLPWDPQFLVESLTDSTIYMAYYTICHLLHSDVY-GK 641

  Fly   619 KPGPFGIKPSDMTGEIWDYIFFKETPLPKKTAIKQEHLAVLRREFEYWYPMDLRVSGKDLIQNHL 683
            .||...|||..||.|:||:: |::.|.||.|:|..|.||.|.|||:|:||.|:|.|||||:.|||
pombe   642 VPGALNIKPEQMTPEVWDHV-FRQAPKPKNTSISDEALARLCREFQYFYPFDIRASGKDLVPNHL 705

  Fly   684 TFCLYNHAAIWPNDENKWPKGMRVNGHLLLNSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAG 748
            |||||.|.||:  ||..||||:|.|||||:|..|||||.|||:||.||..||.||..||.|||||
pombe   706 TFCLYTHTAIF--DEKYWPKGIRANGHLLMNGEKMSKSTGNFMTLHEATKKFGADATRLALADAG 768

  Fly   749 DSVEDANFVESTADAGILRLYTFIEWVKEMLENRSSLRKGTDKTFNDQVFLSELNLKTQQTDENY 813
            |:|:||||.|:.|::.||||||...|.|||:||..:||.| ...|:|:||.:|:|...:.:.|.:
pombe   769 DTVDDANFEEALANSAILRLYTQEAWCKEMMENLDNLRTG-PYNFHDKVFENEINQLIESSREAF 832

  Fly   814 RKMLFKEALRSGFYELQLARDKYRELCGANGMHEDLVLEFIRRQALLVSPICPHMAEHVWGLLGN 878
            ...|||.||:|.||:||.|||.|||:.....||.|||..:|..|.||::...||.:||:|.....
pombe   833 SATLFKAALKSCFYDLQNARDWYREVTADRKMHRDLVCRWIETQVLLLATFAPHWSEHIWLTTLK 897

  Fly   879 KESIVH--ARWPEVGAINEVDILCSEYLM------------EAAHSFRLNLKNLLQIKGKAGKDK 929
            |...:|  .|:|:|.  :.|:...|..|:            |||           |:| :..|.|
pombe   898 KPQSIHVSGRFPQVS--SPVNTALSNSLLYIRTLSRVIREAEAA-----------QLK-RQKKGK 948

  Fly   930 SVNVQAAKPNRGLVWVAKTYPPWQCCVLDTMKELFNKSQALPDNKVIAATLQQKAELKKFMKRVM 994
            .:....:||.|..|:||:.:|.||...:..:::.:|:|:...|:|.|.:::.     ||.|||.|
pombe   949 GMLFDPSKPKRLTVFVAEKFPEWQAQYVALLQKYYNESENKFDDKAIISSVD-----KKEMKRAM 1008

  Fly   995 PFAQMIREKV-ESGKGVAALAV---TLEFDERQVLISNLEYLKNTLDLDVLEIKYTDDPSAPEKT 1055
            ||.|..::.| ..|:.|:|.::   .|.|:|.:||.....||...:.:..|.|.....|:  :|:
pombe  1009 PFIQQFKQSVINRGEHVSANSIFSRELGFNELEVLREVKPYLVRNVGIQELRIVLLQKPA--DKS 1071

  Fly  1056 REE---VRPGSPF-ISFSVAPNVSVELTNPIERSSLFQ 1089
            ...   |..||.. .:..:|||.:  .|.|.:.:.||:
pombe  1072 SAAIGLVESGSDAGATVEIAPNFA--NTVPGQPTFLFE 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_787968.1	PLN02959	1..1068	CDD:215518	532/1120 (48%)
lrs1	NP_594882.1	PLN02959	21..1106	CDD:215518	532/1120 (48%)