Protein Alignment: LeuRS and Lars2

• Sequence 1: NP_001285589.1
• Gene: LeuRS
• FlyBaseID: FBgn0284253
• Length: 1182
• Species: Drosophila melanogaster
• Sequence 2: NP_001335096.1
• Gene: Lars2
• MGIID: 2142973
• Length: 902
• Species: Mus musculus
• Alignment Length: 1014
• Identity: 193/1015 (19%)
• Similarity: 329/1015 (32%)
• Gaps: 361/1015 (36%)

  Fly     8 GTFKVEYLQKIEREVQQRW------EAERVHESDAPTAPKKRQAEKFFVTFPFPYMNGRLHLGHT 66
            |.:..||..:..::|::.|      :|.||.|.|       :...||::...|||.:|:||:||.
Mouse    44 GKWTKEYTLQTRKDVEKWWHQQIKEQASRVSEED-------KLKPKFYLLSMFPYPSGKLHMGHV 101

  Fly    67 FSLSKAEYSMRYHRLKGRRVLWPFGFHCTGMPIKACADKLTRELEQFGFPPQFPETEEVVPVAAE 131
            ...:.::...|:.:::|.:|:.|.|:...|:|.:..|  :.|.|.        ||:
Mouse   102 RVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAA--IERNLH--------PES--------- 147

  Fly   132 AASEVPKDKSKGKKSKAVAKTGAAKYQWQIMQSLGLKDEEIKDFANAEHWLNYFPPLAVQDLKRI 196
                                       |  .||            |.:|..        :.|.|:
Mouse   148 ---------------------------W--TQS------------NIKHMR--------KQLDRL 163

  Fly   197 GVHVDWRRTFITTDANPYFDSFVRWQFNHLKERGKIMYGKRYTI-YSPKDGQPCMDHDRSSGEGV 260
            |:...|.|. |||....|: .:.::.|..|.|.| :.|.|...: :.|.| |..:.:::.:..|.
Mouse   164 GLCFSWDRE-ITTCLPDYY-KWTQYLFIKLYEAG-LAYQKEALVNWDPVD-QTVLANEQVNEYGC 224

  Fly   261 GPQEYTLIKMKVLE--------VPKALSSIKQPIFMVAATLRPETMYGQTNCWLHPDIKYIAWQA 317
            ..:....::.|.|.        ..||:..        |....|| .||......|
Mouse   225 SWRSGAKVEKKYLRQWFIKTTAYAKAMQD--------ALADLPE-WYGIKGMQAH---------- 270

  Fly   318 NKNNEVWVSTRRAARNMTYQGFTAVEGEIKVLAEVTGQDLLGVPLSAPLTKHKVVYSLPMLSIKE 382
                  |:.             ..|...:....:|.|:| .|..|:|.....:.:|.:..::|..
Mouse   271 ------WIG-------------DCVGCHLDFTLKVDGED-TGEKLTAYTATPEAIYGISHVAISP 315

  Fly   383 DKG-------------TGVVTSVPSDSPDDYAALVDLQKKEAFRQKYGLKDEMVLPYEPIPIIEV 434
            ..|             ..:|......:|....:::.||:                  .||.|:..
Mouse   316 SHGLLHGCSSVKKALQKALVPGRDCLTPVMAVSMLTLQE------------------VPIVIMAN 362

  Fly   435 PTL-GKLSAVHAYETLKIQSQNDKD-KLAEAKEMCY---LKSFYDGV-MLVGA--FAGRKIQDVK 491
            |.| |.|.:     .:.|.|.:.:| :||:|..:.|   :::..||. .|.|:  |.|...||..
Mouse   363 PDLEGSLDS-----KIGIPSTSSEDTRLAQALGLPYSEVIEASPDGTERLSGSAEFTGMTRQDAF 422

  Fly   492 KDLQKRL----VDANEADVYYEPEKTIMSRSADECVVALCNQWYLNYGEPEWQAQATKILH---- 548
            ..|.::.    |..:           :.|....:.:::....|    |.|      ..|:|
Mouse   423 VALTRKARGMRVGGH-----------VTSNKLKDWLISRQRYW----GTP------IPIVHCPAC 466

  Fly   549 ---------------GMETFHEEARNNFEACLNWLHEYACSRTYGLGTKLPWDDKWLIESLSDST 598
                           .:.:......:.....|.|:: .:|.|..| ..|...|   .:::..||.
Mouse   467 GPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVN-CSCPRCKG-SAKRETD---TMDTFVDSA 526

  Fly   599 IYMAFYTVVHLLQGGTFRGEKPGPFGIKPSDMTGEIWDYIFFKETPLPKKTAIKQEHLAVLRREF 663
            .|...||..|..|         .|||...:|
Mouse   527 WYYFRYTDPHNTQ---------SPFGSALAD---------------------------------- 548

  Fly   664 EYWYPMDLRVSGKDLIQNHL-------TFC----LYNH---------AAIWPNDENKWPKGM--- 705
             :|.|:||.:.||:....||       .||    :..|         ..:......:.|.|.
Mouse   549 -FWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQCLK 612

  Fly   706 --------------RVNGHLLLNSAKMSKSDGNFLTLTEAVDKFSADGMRLCLADAGDSVEDANF 756
                          :....|.:...|||||..|.:...|.|.::..|.:||.:..|....:|..:
Mouse   613 KEDIDFTGPAPVCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 677

  Fly   757 -VESTADAGILRLYTFIEWVKEM-------LENRSSLRKGTDKTFNDQVFLSELNLKTQQTDENY 813
             |::.|..|:||      |.:.:       :|.|:|   ||  ....|:..|:...|.|...| |
Mouse   678 DVKTDALPGVLR------WQQRLWSLTTRFIEARTS---GT--VPQPQLLNSKEKTKAQNLWE-Y 730

  Fly   814 RKMLFKEALRSGFYELQLARDKYRELCGANG----------MH----EDLVLEFIRRQALLV--S 862
            :..:..: :.:.|.|.........:|.|.:.          :|    ||.:.      ||||  :
Mouse   731 KNAVIAQ-VTTHFTEDFALNSVVSQLMGLSSALSQASQRVVLHSPEFEDALC------ALLVMAA 788

  Fly   863 PICPHMAEHVWG---LLGNK--------ESIVHARWPEV 890
            |:.||:...:|.   |:.:|        ..::...||.|
Mouse   789 PLAPHVTSELWAGLTLVPSKLCDHYAWDSGVMLQAWPTV 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LeuRS	NP_001285589.1	PLN02959	1..1068	CDD:215518	193/1015 (19%)
		nt_trans	47..>204	CDD:294020	31/157 (20%)
		LeuRS_core	<525..758	CDD:173906	51/290 (18%)
		Anticodon_Ia_Leu_AEc	756..876	CDD:153413	33/147 (22%)
Lars2	NP_001335096.1	tRNA-synt_1g	56..900	CDD:330949	190/1003 (19%)
		'HIGH' region	91..101		6/10 (60%)
		'KMSKS' region	638..642		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	1	0.900				E1_COG0495
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900