DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11583 and Brix1

DIOPT Version :9

Sequence 1:	NP_001033989.1	Gene:	CG11583 / 326206	FlyBaseID:	FBgn0035524	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_080672.3	Gene:	Brix1 / 67832	MGIID:	1915082	Length:	353	Species:	Mus musculus

Alignment Length:	361	Identity:	164/361 - (45%)
Similarity:	230/361 - (63%)	Gaps:	36/361 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GRKFQNKKKKAAPQLEIVPLDENPPL-------PPQRSSDDVVPK---KEKWVNKQRVLVFSARG 56
            |.:.|.||.|.:.:      |...|.       ..:..:.|.:|.   |.||.||:|:|:||:||
Mouse    11 GLEVQAKKPKRSSK------DAGQPAKQADVAKEAEEENRDRIPGPVCKGKWKNKERILIFSSRG 69

  Fly    57 ISHRDRHLMKDIKTLMPHHRPESKMERSKTLSVVNEMCEMKHCNKAMLFEGRRKRDLYMWISNTS 121
            |:.|.||||:|::.||||.:.::||:|...|.|:||:||||:|||.:.||.::|:|||||:||:
Mouse    70 INFRTRHLMQDLRMLMPHSKADTKMDRKDKLFVINEVCEMKNCNKCIYFEAKKKQDLYMWLSNS- 133

  Fly   122 GSTGPSAKFLIENIHTMAELKMTGNCLRGSRPLLSFDSKFDELPHLKLLKELFVQTYSVPNHHPK 186
             ..|||||||::||||:||||||||||:|||||||||..||:|||..||||..:|.:|.|.:|||
Mouse   134 -PHGPSAKFLVQNIHTLAELKMTGNCLKGSRPLLSFDPAFDDLPHYALLKEFLIQIFSTPRYHPK 197

  Fly   187 SQPFVDHVFTFTYLDKRIWFRNFQILSEDGGLSEVGPRYVMNPVKIFDGSFTGKTIWENPDYVSP 251
            ||||||||||||.||.|||||||||:.||..|.|:|||:|:|.:|||.|||.|.|::|||.|.||
Mouse   198 SQPFVDHVFTFTILDNRIWFRNFQIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPHYQSP 262

  Fly   252 SKQRQVLKKAAKDKYVNRVE----QKVKHEATRPIRAYDGMDNDELFEDDDPVETAKILAAIAKK 312
            :..|:|::.....||..|.:    ||::.:..:.|..:|              .||.:....|::
Mouse   263 NMHRRVIRSITAAKYRERQQVKDVQKLRKKEPKTILPHD--------------PTADVFVIPAEE 313

  Fly   313 KKEEAAKQTPKSALTKKIKEKQLQAVKDVIERKKAR 348
            |..|.....|:..:..|.:::::......:::|.:|
Mouse   314 KPVEIQWVKPEPKVDLKARKRRIYKRHRKLQQKMSR 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11583	NP_001033989.1	Brix	43..290	CDD:294606	144/250 (58%)
Brix1	NP_080672.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		9/44 (20%)
		Brix	36..307	CDD:294606	150/286 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..353		2/16 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837945
Domainoid	1	1.000	257	1.000	Domainoid score	I2007
eggNOG	1	0.900	-	-		E1_COG5154
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10133
Inparanoid	1	1.050	323	1.000	Inparanoid score	I2481
Isobase	1	0.950	-	0	Normalized mean entropy	S699
OMA	1	1.010	-	-		QHG54029
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004244
OrthoInspector	1	1.000	-	-		oto92776
orthoMCL	1	0.900	-	-		OOG6_101913
Panther	1	1.100	-	-	LDO	PTHR13634
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2983
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.710