DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scramb1 and Plscr2

DIOPT Version :9

Sequence 1:	NP_648389.3	Gene:	scramb1 / 326186	FlyBaseID:	FBgn0052056	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_006510920.1	Gene:	Plscr2 / 18828	MGIID:	1270860	Length:	320	Species:	Mus musculus

Alignment Length:	367	Identity:	166/367 - (45%)
Similarity:	198/367 - (53%)	Gaps:	65/367 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 HPQPPPPTNYGF-MPGPQ-----PAGYAPVPQMPPYG-EAPPYGAGQPPYMGGPGGQPPYAGGPG 105
            ||.|    :.|. |..|:     |||||  ||.||.. :.||...|:|.:.  ...|.|.:|.||
Mouse     5 HPSP----HTGLQMEAPRSGTYLPAGYA--PQYPPAAVQGPPEHTGRPTFQ--TNYQVPQSGYPG 61

  Fly   106 GQPPYVGGPGGQPHYGGGAPPPQAFGGYPPGPAGPGGPPNAFGGYPPGQPQQPIV---TQPGMGP 167
            .|..|.....|...|.....|.                          |..|.||   ||
Mouse    62 PQASYTVSTSGHEGYAATRLPI--------------------------QNNQTIVLANTQ----- 95

  Fly   168 GMGPGMAPQGGPAGDWMSIPTGIPNCPRGLEYLTTIDQLLVKQKVELLEAFTGFETNNKFTIKNA 232
                           ||..|..|.|||.|||||..|||||:.|:|||||..|||||||||.|||:
Mouse    96 ---------------WMPAPPPILNCPPGLEYLNQIDQLLIHQQVELLEVLTGFETNNKFEIKNS 145

  Fly   233 LGQKVYFAAEDNDCCTRNCCGPARPFDMRVFDNFQQEVIHMHRPLACSSCLFPCCLQSIEVSAPP 297
            |||.||.|.||.||||||||..:|||.:|:.|:..|||:.:.|||.||||.||||||.||:.|||
Mouse   146 LGQMVYVAVEDTDCCTRNCCEASRPFTLRILDHLGQEVMTLERPLKCSSCCFPCCLQEIEIQAPP 210

  Fly   298 GNVIGTIEQEWSICSPSFRILNHVGDTVMRIEGPFCTFSLCGDVEFNVVSLTG-EKIGKISKQWS 361
            |..||.:.|.|..|.|...:.|...:.|:::.||....:.|.|::|.:.||.. .:||||:||||
Mouse   211 GVPIGYVTQTWHPCLPKLTLQNDKRENVLKVVGPCVACTCCSDIDFEIKSLDEVTRIGKITKQWS 275

  Fly   362 GLAREIFTDADFFGINFPLDLDVRMKAVLLGATFLIDAMFFE 403
            |..:|.|||:|.|||.|||||:|:||||.|||.||||.||||
Mouse   276 GCVKEAFTDSDNFGIQFPLDLEVKMKAVTLGACFLIDYMFFE 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scramb1	NP_648389.3	Sox_C_TAD	<61..>129	CDD:288887	24/73 (33%)
scramb1	NP_648389.3	Scramblase	184..404	CDD:252175	130/221 (59%)
Plscr2	XP_006510920.1	Scramblase	97..317	CDD:252175	128/219 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845459
Domainoid	1	1.000	286	1.000	Domainoid score	I1592
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2457
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	1	1.000	-	-		mtm8892
orthoMCL	1	0.900	-	-		OOG6_100156
Panther	1	1.100	-	-	O	PTHR23248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760